Hepatoprotective and antioxidant potential of ferulic acid against acetaminophen-induced liver damage in mice

Krishnan, Dhanalakshmi Navaneetha; Prasanna, N. D.; Sabina, Evan Prince; Rasool, Mahaboobkhan

doi:10.1007/s00580-012-1546-y

Cited by 13 publications

(11 citation statements)

References 22 publications

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“…It was reported that ALP was involved in immune defence mechanisms and was correlated with the immune competence (Li et al., ). In studies on rats, the increase in ALP clearly exhibited that FA possessed promising hepato‐protective potential (Krishnan, Prasanna, Sabina, & Rasool, ; Panneerselvam, Subbiah, Arumugam, & Senapathy, ). The improvement of serum biochemistry parameters of FA‐supplemented groups in this study indicated that the tilapia might have better health status.…”

Section: Discussionmentioning

confidence: 99%

Ferulic acid: A natural compound as an efficient feed additive for GIFT (Oreochromis niloticus)

Jiang

et al. 2017

Aquacult Nutr

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This study aimed to investigate the effect of dietary ferulic acid (FA) supplementation on growth performance, antioxidant capacity and some physical characteristics of flesh in genetic improvement of farmed tilapia (GIFT) juveniles. Five diets supplemented with 0, 50, 100, 200 and 400 mg/kg FA were prepared. Weight gain was significantly increased, while feed conversion ratio, viscerosomatic index and hepatosomatic index were significantly decreased in fish fed FA diet at 100 mg/kg feed (p < .05). FA supplementation improved hepatic and serum superoxide dismutase and catalase activities, but decreased the malondialdehyde content (p < .05). Furthermore, with the addition of FA, serum triacylglycerol, cholesterol, low‐density lipoprotein cholesterol contents, alanine aminotransferase and aspartate transaminase activities were reduced, whereas serum high‐density lipoprotein cholesterol content, alkaline phosphatase and lysozyme activities were enhanced. The texture profile analysis parameters and water‐holding capacity tended to increase while cooking loss was decreased by dietary FA supplementation (p < .05). These results suggested that dietary FA supplementation increased the growth performance and antioxidant capacity of GIFT, and improved some physical characteristics of flesh and serum biochemical parameters. The optimum dietary FA level was 100 mg/kg in diet.

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Section: Discussionmentioning

confidence: 99%

Ferulic acid: A natural compound as an efficient feed additive for GIFT (Oreochromis niloticus)

Jiang

et al. 2017

Aquacult Nutr

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“…This is achieved by activating the ARE via the transcription factor Nrf2 [160]. These animal studies have been done with a wide range of pro‐oxidant stressors including alloxan, nicotine, acetaminophen, radiation, u/v light, carcinogens, and exercise [160–171]. While human studies are lacking, this animal work suggests that ferulic acid could serve as a key anti‐oxidant in human physiology also.…”

Section: Roles For Oxidation In Type 2 Diabetes Coronary Heart Dmentioning

confidence: 99%

Whole grains, type 2 diabetes, coronary heart disease, and hypertension: Links to the aleurone preferred over indigestible fiber

et al. 2013

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Higher whole grain cereal intakes are associated with substantially lower risks of type 2 diabetes, coronary heart disease, and hypertension. These reduced risks have been established in large prospective studies that now include millions of person-years of follow-up. We analyze the results of 11 major prospective studies to provide recommendations about whole grain consumption. The following review establishes the amount of whole grains that should ideally be consumed based on prospective evidence; defines the nature of whole grains; identifies that the whole grain evidence is robust and not due to confounding; and provides a detailed assessment of several potential mechanisms for the effect of whole grains on health. We draw the following conclusions. Firstly, to maintain health, 40 grams or more of whole grains should be consumed daily. This is about a bowl of whole grain breakfast cereal daily, but 80% of the population does not achieve this. Secondly, aleurone in bran is a critical grain component generally overlooked in favor of indigestible fiber. Live aleurone cells constitute 50% of millers’ bran. They store minerals, protein, and the antioxidant ferulic acid, and are clearly more than just indigestible fiber. Finally, we suggest potential roles for magnesium, zinc, and ferulic acid in the development of chronic disease. If the results of prospective studies were applied to the life-style practices of modern societies there exists the potential for enormous personal health and public financial benefits.

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“…FA has also been reported as anti-inflammatory (Gohil et al 2012;Murakami et al 2002), anti-diabetic (Mancuso and Santangelo 2014;Ohnishi et al 2004;Song et al 2014), hepatoprotective (Krishnan et al 2013;Kim et al 2011;Al Maruf et al 2015;Panneerselvam et al 2013), anti-hyperlipidemic, andanti-atherogenic (Marimuthu et al 2013;Kwon et al 2010), neuroprotective Koh 2012Koh , 2013, anti-cancer, and anti-apoptotic effects (Serafim et al 2011;Thakkar et al 2014). However, the potential usefulness of this compound has not yet been explored in painful neuropathy.…”

Section: Introductionmentioning

confidence: 99%

Ferulic acid ameliorates chronic constriction injury induced painful neuropathy in rats

Aswar

Patil²

2016

Inflammopharmacol

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Hepatoprotective and antioxidant potential of ferulic acid against acetaminophen-induced liver damage in mice

Cited by 13 publications

References 22 publications

Ferulic acid: A natural compound as an efficient feed additive for GIFT (Oreochromis niloticus)

Ferulic acid: A natural compound as an efficient feed additive for GIFT (Oreochromis niloticus)

Whole grains, type 2 diabetes, coronary heart disease, and hypertension: Links to the aleurone preferred over indigestible fiber

Ferulic acid ameliorates chronic constriction injury induced painful neuropathy in rats

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