Ferulic acid ameliorates chronic constriction injury induced painful neuropathy in rats

Aswar, Urmila; Patil, Varsha

doi:10.1007/s10787-016-0272-5

Cited by 22 publications

(14 citation statements)

References 57 publications

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“… 39 Previous reports refer to antinociceptive action of ferulic acid (monomer, FAM) through the opioid pathway, as it has shown positive results in neurogenic pain models. 30 , 39 In the current study, FAM did not suppress acute pain in male mice although it was as potent as FAD in alleviating late-phase pain in female mice. Several reports have suggested that there is a clear sex difference in pain perception and pain inhibition in both human and mouse models.…”

Section: Discussioncontrasting

confidence: 43%

“… 8 As indicated earlier, FAM has been shown to suppress neurogenic pain via opioid receptor action. 30 , 39 With the experiments performed so far, we believe that FAD does not work through the opioid pathway as it suppresses only inflammatory response in formalin model and did not show any apparent neurogenic locomotor impairment, and opioid antagonist did not reverse its antinociceptive effect. In addition, mechanical hyperalgesia and thermal sensitivity tests indicate that normal nociception was retained in mice after FAD treatment, which suggests that neurologic functions are maintained.…”

Section: Discussionmentioning

confidence: 89%

“…FAM has shown antinociceptive effects in some models of neuropathic pain primarily induced through nerve injury or administration of chemotherapeutic agents, although we did not observe such response in the male mice at the dose used. 30 , 31 On the contrary, FAD showed a maximum suppression of late-phase pain response at the 30 mg/kg dose ( Figure 7 ), which was subsequently used for studying gender differences and receptor responses.…”

Section: Resultsmentioning

confidence: 99%

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Ferulic acid dimer as a non-opioid therapeutic for acute pain

Priebe¹,

Hunke²,

Tonello³

et al. 2018

JPR

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PurposeSearch for alternate pain medications has gained more importance in the past few years due to adverse effects associated with currently prescribed drugs including nervous system dysfunction with opioids, gastrointestinal discomfort with nonsteroidal anti-inflammatory drugs, and cardiovascular anomalies with cyclooxygenase-2 (COX-2) inhibitors. Phytomedicine has been explored for the treatment of pain, as these have been used for generations in regional communities and tend to lack major side effects in general. One such phytomedicine, incarvillateine (INCA), derived from the Chinese herb Incarvillea sinensis has its primary antinociceptive action through the adenosine receptor, a novel pain target. We hypothesized that derivatives of cinnamic acid dimers, which are structurally similar to INCA, would show potent antinociceptive action and that their effect would be mediated through adenosine receptor action.Materials and methodsDimers of cinnamic acid (INCA analogs) were synthesized using cavitand-mediated photodimerization (CMP) method, which utilizes a macromolecule (γ-cyclodextrin) to control excited state reactivity of photoactive compounds. Acute pain response was assessed by using formalin-induced licking behavior in hind paw of mice, and neurologic function was monitored through locomotor activity, mechanical hyperalgesia, and thermal sensitivity upon administration of test compound. For mechanistic studies, binding to adenosine receptor was determined by using computer modeling.ResultsFerulic acid dimer (FAD), which has the same chemical functionalities on the aromatic ring as INCA, showed significant suppression of formalin-induced acute pain. Antinociceptive effect was observed primarily in the inflammatory phase, and no apparent behavioral changes related to the nervous system were noticeable. Inhibition of opioid receptor did not reverse antinociceptive response, and modeling data suggest adenosine 3 receptor binding.ConclusionFAD (INCA analog) shows potent nonopioid antinociceptive action mediated predominantly through A3AR – adenosine 3 receptor action. Further characterization and selection of such INCA analogs will help us generate a new class of antinociceptives with precise chemical modifications by using CMP methodology.

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Section: Discussioncontrasting

confidence: 43%

Section: Discussionmentioning

confidence: 89%

Section: Resultsmentioning

confidence: 99%

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Ferulic acid dimer as a non-opioid therapeutic for acute pain

Priebe¹,

Hunke²,

Tonello³

et al. 2018

JPR

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show abstract

“…[16]; dose-dependent amelioration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced loss of nigrostriatal dopaminergic neurons, the decrease of the Bax/Bcl2 ratio, reduction of pro-apoptotic protein Bax levels and increased expression of anti-apoptotic protein Bcl2 in PD C57BI/6 mice model (ferulic acid was given via injections for 7 days, at a dose of 20, 40 and 80 mg/kg) [17];…”

Section: Figurementioning

confidence: 99%

The Neuroprotective Effects of Phenolic Acids: Molecular Mechanism of Action

2017

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The neuroprotective role of phenolic acids from food has previously been reported by many authors. In this review, the role of phenolic acids in ameliorating depression, ischemia/reperfusion injury, neuroinflammation, apoptosis, glutamate-induced toxicity, epilepsy, imbalance after traumatic brain injury, hyperinsulinemia-induced memory impairment, hearing and vision disturbances, Parkinson’s disease, Huntington’s disease, anti-amyotrophic lateral sclerosis, Chagas disease and other less distributed diseases is discussed. This review covers the in vitro, ex vivo and in vivo studies concerning the prevention and treatment of neurological disorders (on the biochemical and gene expression levels) by phenolic acids.

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“…In the present study an attempt was made to explore the potential effects of naturally isolated ECN in PSNL-induced model of neuropathic pain. PSNL model has been used clinically for the treatment of neuropathic pain [25]. Intraperitoneal administration of ECN (10 mg/kg) post-treatment once daily starting from day 3 after surgery, significantly attenuated mechanical hyperalgesia, thermal hyperalgesia, mechanical allodynia and cold allodynia.…”

Section: Discussionmentioning

confidence: 99%

ECN from <em>Tussilago Farfara</em> Attenuates Neuropathic Pain by Suppressing Oxidative Stress, Inflammatory and Pro-Apoptotic Proteins Expression in Surgical Model

Khan¹,

Khalid²,

Khan³

et al. 2020

Preprint

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7β-(3-ethyl-cis-crotonoyloxy)-1α-(2-methylbutyryloxy)-3,14-dehydro-Z-notonipetranone (ECN), a sesquiterpenoid obtained from a natural origin (Tussilago farfara)has proved to be effective in minimizing various side effects associated with opioids and nonsteroidal anti-inflammatory drugs. The current study focused on investigating the effects of ECN on neuropathic pain induced by partial sciatic nerve ligation (PSNL) by mainly focusing on oxidative stress, inflammatory and apoptotic proteins expression in mice. Neuropathic pain was induced in mice by PSNL surgery performed on day 1 and ECN (1 and 10 mg/kg, i.p.), was administered once daily for 11 days, starting from the third day after surgery. ECN post-treatment was found to reduce hyperalgesia and allodynia in a dose dependent manner. ECN significantly reversed the severity of neuropathic pain by improving distress symptoms and survival rate. ECN remarkably reversed the histopathological abnormalities associated with oxidative stress, apoptosis and inflammation. Furthermore, ECN prevented the suppression of antioxidants (glutathione, glutathione-S-transferase, catalase, superoxide dismutase, NF-E2-related factor-2 (Nrf2), hemeoxygenase-1 and NAD(P)H: quinone oxidoreductase) by PSNL. Moreover, pro-inflammatory cytokines (tumor necrotic factor alpha, interleukin 1 beta, interleukin 6, cyclooxygenase-2 and inducible nitric oxide synthase) expression was reduced by ECN administration. Treatment with ECN was successful in reducing caspase-3 level consistent with the observed modulation of pro-apoptotic proteins. Additionally, ECN showed protective effect on the lipid content of myelin sheath as evident from FTIR spectroscopy which showed the shift of lipid component bands to higher values. Thus, anti-neuropathic potential of ECN might be due to inhibition of oxidative stress, inflammatory mediators and pro-apoptotic proteins.

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Ferulic acid ameliorates chronic constriction injury induced painful neuropathy in rats

Abstract: In conclusion, the anti-hyperalgesic effect of FA in rats receiving CCI might partly be attributed to its anti-oxidant and anti-inflammatory activity and is associated with the maintenance of neuropathic pain and could be useful as an adjuvant to conventional medicines.

Cited by 22 publications

References 57 publications

Ferulic acid dimer as a non-opioid therapeutic for acute pain

Ferulic acid dimer as a non-opioid therapeutic for acute pain

The Neuroprotective Effects of Phenolic Acids: Molecular Mechanism of Action

ECN from <em>Tussilago Farfara</em> Attenuates Neuropathic Pain by Suppressing Oxidative Stress, Inflammatory and Pro-Apoptotic Proteins Expression in Surgical Model

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