Hepatoprotective and Antioxidant Effects of &amp;lt;i&amp;gt;Salvia officinalis&amp;lt;/i&amp;gt; L. Hydroalcoholic Extract in Male Rats

Khakpour, Shahrzad; Mahya, Najari; Fatemeh, Tokazabani Belasei; Khosravi, Maryam; Mohammadreza, Farhadi Belasei; Jahromy, Mahsa Hadipour

doi:10.4236/cm.2014.52016

Cited by 7 publications

(4 citation statements)

References 14 publications

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“…Recently, another study reported that sage essential oil reduces oxidative stress and the toxic effects in liver injury which was induced by vanadium metal in rat liver [31]. Similarly, another study observed that sage protected the liver against isoniazid-induced hepatic toxicity [51]. In this regard, the Salvia officinalis leaves' methanolic extract also protected the liver injury induced by aflatoxins [52].…”

Section: In Vivo Hepatoprotective Effectmentioning

confidence: 99%

Sage, Salvia officinalis L., Constituents, Hepatoprotective Activity, and Cytotoxicity Evaluations of the Essential Oils Obtained from Fresh and Differently Timed Dried Herbs: A Comparative Analysis

et al. 2021

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Sage, Salvia officinalis L., is used worldwide as an aromatic herb for culinary purposes as well as a traditional medicinal agent for various ailments. Current investigations exhibited the effects of extended dryings of the herb on the yields, composition, oil quality, and hepatoprotective as well as anti-cancer biological activities of the hydrodistillation-obtained essential oils from the aerial parts of the plant. The essential oils’ yields, compositions, and biological activities levels of the fresh and differently timed and room-temperature dried herbs differed significantly. The lowest yields of the essential oil were obtained from the fresh herbs (FH, 631 mg, 0.16%), while the highest yield was obtained from the two-week dried herbs (2WDH, 1102 mg, 0.28%). A notable decrease in monoterpenes, with increment in the sesquiterpene constituents, was observed for the FH-based essential oil as compared to all the other batches of the essential oils obtained from the different-timed dried herbs. Additionally, characteristic chemotypic constituents of sage, i.e., α-pinene, camphene, β-pinene, myrcene, 1, 8-cineole, α-thujone, and camphor, were present in significantly higher proportions in all the dried herbs’ essential oils as compared to the FH-based essential oil. The in vivo hepatoprotective activity demonstrated significant reductions in the levels of AST, ALT, and ALP, as well as a significant increase in the total protein (p < 0.05) contents level, as compared to the acetaminophen (AAP) administered experimental group of rats. A significant reduction (p < 0.05) in the ALT level was demonstrated by the 4WDH-based essential oil in comparison to the FH-based essential oil. The levels of creatinine, cholesterol, and triglycerides were reduced (p < 0.05) in the pre-treated rats by the essential oil batches, with non-significant differences found among them as a result of the herbs dryings based oils. A notable increase in the viability of the cells, and total antioxidant capacity (TAOxC) levels, together with the reduction in malondialdehyde (MDA) levels were observed by the essential oils obtained from all the batches as compared with the AAP-treated cell-lines, HepG-2, HeLa, and MCF-7, that indicated the in vitro hepatoprotective effects of the sage essential oils. However, significant improvements in the in vivo and in vitro hepatoprotective activities with the 4WDH-based oil, as compared to all other essential oil-batches and silymarin standard demonstrated the beneficial effects of the drying protocol for the herb for its medicinal purposes.

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Section: In Vivo Hepatoprotective Effectmentioning

confidence: 99%

Sage, Salvia officinalis L., Constituents, Hepatoprotective Activity, and Cytotoxicity Evaluations of the Essential Oils Obtained from Fresh and Differently Timed Dried Herbs: A Comparative Analysis

et al. 2021

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“…Significant reductions in the total cholesterol, triglycerides, low-density lipoprotein, and C-reactive protein was found, along with a decrease in body weight and abdominal fat mass [93]. Several other studies illustrated various positive metabolic changes in animal studies [94,95]. A non-randomized crossover trial on six women who consumed 600 mL of sage infusion per day during 4 weeks, followed by 2 weeks of a wash-out period, found no effect on plasma glucose, but the level of LDL and the total cholesterol lowered, while HDL increased [96].…”

Section: Sage and Health Benefitsmentioning

confidence: 99%

Bioactive Profile of Various Salvia officinalis L. Preparations

Jakovljević

Jokić

Molnar

et al. 2019

Plants

102

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Salvia officinalis L., also known as the “Salvation Plant”, has been long used and well-documented in traditional medicine around the globe. Its bioactive compounds, and especially its polyphenol profile, have been extensively researched and reviewed. However, sage’s beneficial effects reach much further, and nowadays, with a range of new extraction techniques, we are discovering new components with new therapeutic effects, especially in the context of neurodegenerative diseases and various carcinomas. This review describes the bioactive profile of various sage preparations depending on the extraction techniques and extraction parameters, and this review lists the newest research findings on its health effects.

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“…The highest antioxidant activities of sage were discovered in the methanolic extract, followed by water infusion and decoction [ 84 ]. The hydroalcoholic extract of sage exhibited high antioxidant activity [ 85 ]. For example, earlier study has shown that the hydroalcoholic extract of sage has hepatoprotective action against isoniazid-induced hepatic damage in rats.…”

Section: Herbal Infusions Antioxidant and Anticancer Capacitiesmentioning

confidence: 99%

The Impact of Herbal Infusion Consumption on Oxidative Stress and Cancer: The Good, the Bad, the Misunderstood

et al. 2020

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The release of reactive oxygen species (ROS) and oxidative stress is associated with the development of many ailments, including cardiovascular diseases, diabetes and cancer. The causal link between oxidative stress and cancer is well established and antioxidants are suggested as a protective mechanism against cancer development. Recently, an increase in the consumption of antioxidant supplements was observed globally. The main sources of these antioxidants include fruits, vegetables, and beverage. Herbal infusions are highly popular beverages consumed daily for different reasons. Studies showed the potent antioxidant effects of plants used in the preparation of some herbal infusions. Such herbal infusions represent an important source of antioxidants and can be used as a dietary protection against cancer. However, uncontrolled consumption of herbal infusions may cause toxicity and reduced antioxidant activity. In this review, eleven widely consumed herbal infusions were evaluated for their antioxidant capacities, anticancer potential and possible toxicity. These herbal infusions are highly popular and consumed as daily drinks in different countries. Studies discussed in this review will provide a solid ground for researchers to have better understanding of the use of herbal infusions to reduce oxidative stress and as protective supplements against cancer development.

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Hepatoprotective and Antioxidant Effects of <i>Salvia officinalis</i> L. Hydroalcoholic Extract in Male Rats

Cited by 7 publications

References 14 publications

Sage, Salvia officinalis L., Constituents, Hepatoprotective Activity, and Cytotoxicity Evaluations of the Essential Oils Obtained from Fresh and Differently Timed Dried Herbs: A Comparative Analysis

Sage, Salvia officinalis L., Constituents, Hepatoprotective Activity, and Cytotoxicity Evaluations of the Essential Oils Obtained from Fresh and Differently Timed Dried Herbs: A Comparative Analysis

Bioactive Profile of Various Salvia officinalis L. Preparations

The Impact of Herbal Infusion Consumption on Oxidative Stress and Cancer: The Good, the Bad, the Misunderstood

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