Hepatoprotective and antioxidant effects of Bupleurum kaoi Liu (Chao et Chuang) extract and its fractions fractionated using supercritical CO2 on CCl4-induced liver damage

Wang, Be-Jen; Liu, Chu-Ting; Tseng, Chin‐Yin; Wu, Chien-Ping; Yu, Zer‐Ran

doi:10.1016/j.fct.2003.11.011

Cited by 60 publications

(26 citation statements)

References 26 publications

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“…Consequently, by trapping oxygen-related free radicals, the flavonol glycosides of F. carica leaf could hinder the free radical interaction with polyunsaturated fatty acids and would abolish the enhancement of the lipid peroxidative process leading to hepatic cell damage. The present results agree with previously reported data (Hewawasam et al, 2004;Janbaz et al, 2004;Wang et al, 2004;Orhan et al, 2007). In order to verify this finding the antioxidant activity of F. carica leaf was determined.…”

Section: Discussionsupporting

confidence: 82%

Antioxidant and hepatoprotective activities of Egyptian moraceous plants against carbon tetrachloride-induced oxidative stress and liver damage in rats

Singab

Ayoub

Ali

et al. 2010

Pharmaceutical Biology

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Section: Discussionsupporting

confidence: 82%

Antioxidant and hepatoprotective activities of Egyptian moraceous plants against carbon tetrachloride-induced oxidative stress and liver damage in rats

Singab

Ayoub

Ali

et al. 2010

Pharmaceutical Biology

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“…In this study, CCl 4 treatment markedly increased the serum levels of AST, ALT, and ALP, which indicated severe liver injury (Wang et al, 2004). The leakage of the marker enzymes into the blood was associated with substantial necrosis, loss of hepatic architecture, hydropic degeneration, fatty changes, Kupffer cell hyperplasia, central vein congestion, and inflammatory infiltration of the liver.…”

Section: Discussionmentioning

confidence: 89%

Hepatoprotective and antioxidant activity ofMelaleuca styphelioideson carbon tetrachloride-induced hepatotoxicity in mice

Al‐Sayed

El-Lakkany

el-Din

et al. 2014

Pharmaceutical Biology

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Context: Liver disease is a serious problem. Polyphenolic compounds have marked antioxidant effect and can prevent the liver damage caused by free radicals. In vitro studies have revealed the strong antioxidant activity of an ellagitannin-rich plant, namely, Melaleuca styphelioides Sm. (Myrtaceae). Objective: In view of the limited therapeutic options available for the treatment of liver diseases, the hepatoprotective potential of the methanol extract of M. styphelioides leaves (MSE) was investigated against CCl 4 -induced liver injury in mice. Materials and methods: MSE was administered (500 and 1000 mg/kg/d p.o.) along with CCl 4 for 6 weeks. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) were determined in the serum. Glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione transferase (GST), and malondialdehyde (MDA) were estimated in the liver homogenate. The bioactive components of MSE were identified by NMR, UV and HRESI-MS/MS data. Results: MSE treatment (500 and 1000 mg/kg/d) markedly inhibited the CCl 4 -induced increase in the levels of AST (31 and 38%), ALT (29 and 32%), ALP (13 and 19%), and MDA (22 and 37%) at the tested doses, respectively. MSE treatment markedly increased the levels of GSH (29 and 57%) and antioxidant enzymes compared with the CCl 4 -treated group. MSE was more effective than silymarin in restoring the liver architecture and reducing the fatty changes, central vein congestion, Kupffer cell hyperplasia, inflammatory infiltration, and necrosis induced by CCl 4 . The LD 50 of MSE was more than 5000 mg/kg. Conclusion: MSE confers potent antioxidant and hepatoprotective effects against CCl 4 -induced toxicity.

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“…(+) PGE2 production [84,92] Saikosaponin B2 (+) PGE2 production [73,84,92] (-) Human coronavirus (HCoV) replication Saikogenin D (-) PGE2 production [95] B. fruticescens Butanol extract (-) Acute inflammation [96] Methanol extract (-) 5-LOX, COX-1 [97] Essential oil (-) Acute inflammation [17] Fruticesaponin B (-) Acute inflammation [96] B. fruticosum Petroleum ether extract (-) IL-1b, IL-6, TNF-a, PGE2 [98] Essential oil (-) Acute and chronic inflammation [18,99] Oxytocin antagonism Antifungal Saikosaponin fraction Hepatoprotective against DMN [100] Morinin L (-) IL-1, IL-6, IL-8, TNF-a, NF-kB [101] Buddlejasaponin IV Hepatoprotective against DMN [100] B. gibraltaricum Methanol extract (-) Acute inflammation [102] Essential oil (-) Acute and chronic inflammation [16,19] Oxytocin antagonism Antibacterial, antifungal Saikosaponin I (-) Acute inflammation [102] B. kaoi Saponin-rich fraction Hepatoprotective against CCL4 [103][104][105][106] (-) sGOT, sGPT, AST and ALT levels (+) IFN-g level Cytotoxic against A549 cell line Water extract (+) IFN-g and GSH levels [66,105] (-) Coxsackie B1 replication Polysaccharide-rich fraction (-) sGOT and sGPT levels [105] (+) IFN-g and GSH levels…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Genus Bupleurum: a review of its phytochemistry, pharmacology and modes of action

Ashour

Wink

2010

Journal of Pharmacy and Pharmacology

225

161

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Objectives Radix Bupleuri represents one of the most successful and widely used herbal drugs in Asia for treatment of many diseases over the past 2000 years. Thorough studies have been carried out on many species of this genus and have generated immense data about the chemical composition and corresponding biological activity of extracts and isolated secondary metabolites. In this work, we review the chemistry and pharmacology of the genus Bupleurum and explore the relationships between the pharmacological effects and the chemical composition of these drugs. Key findings Early studies on the genus Bupleurum had focused only on the traditional uses of the plants in the treatment of inflammatory disorders and infectious diseases. After chemical profiling, several groups of secondary metabolites were characterized with relevant biological activity: triterpene saponins (saikosaponins), lignans, essential oils and polysaccharides. As a result, present interest is now focused on the bioactivity of the isolated triterpene saponins acting as immunomodulatory, anti-inflammatory and antiviral agents, as well as on the observed ant-iulcer activity of the polysaccharides and anti-proliferative activity of different lignans. Many saikosaponins exhibited very potent anti-inflammatory, hepatoprotective and immunomodulatory activities both in vivo and in vitro. Conclusions Further investigations and screenings are required to explore other Bupleurum species, to evaluate the clinical safety and possible interactions with other drugs or herbs. Standardization of Bupleuri extracts is crucial for them being integrated into conventional medicine due to large chemical and biological variations between different species and varieties.

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Hepatoprotective and antioxidant effects of Bupleurum kaoi Liu (Chao et Chuang) extract and its fractions fractionated using supercritical CO2 on CCl4-induced liver damage

Cited by 60 publications

References 26 publications

Antioxidant and hepatoprotective activities of Egyptian moraceous plants against carbon tetrachloride-induced oxidative stress and liver damage in rats

Antioxidant and hepatoprotective activities of Egyptian moraceous plants against carbon tetrachloride-induced oxidative stress and liver damage in rats

Hepatoprotective and antioxidant activity ofMelaleuca styphelioideson carbon tetrachloride-induced hepatotoxicity in mice

Genus Bupleurum: a review of its phytochemistry, pharmacology and modes of action

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