Antioxidant and hepatoprotective activities of Egyptian moraceous plants against carbon tetrachloride-induced oxidative stress and liver damage in rats

Singab, Abdel Nasser B.; Ayoub, Nahla; Ali, Eman Noaman; Mostafa, Nada M.

doi:10.3109/13880201003730659

Cited by 54 publications

(36 citation statements)

References 66 publications

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“…Dietary supplementation of figs notably inhibited the accumulation of MDA and protein carbonyl levels in cortex and hippocampus of Tg mice, which is an oxidized by-product of lipid peroxidation. This context was supported by the previous studies that the figs and figs leaves could reduce MDA level, an index of lipid peroxidation [27] on carbon tetrachloride induced rats [52]. …”

Section: Discussionsupporting

confidence: 68%

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Chronic Dietary Supplementation of 4% Figs on the Modification of Oxidative Stress in Alzheimer’s Disease Transgenic Mouse Model

Subash

Essa

Al‐Asmi

et al. 2014

BioMed Research International

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We assessed the changes in the plasma Aβ, oxidative stress/antioxidants, and membrane bound enzymes in the cerebral cortex and hippocampus of Alzheimer's disease (AD) transgenic mice (Tg2576) after dietary supplementation of Omani figs fruits for 15 months along with spatial memory and learning test. AD Tg mice on control diet without figs showed significant impairment in spatial learning ability compared to the wild-type mice on same diet and figs fed Tg mice as well. Significant increase in oxidative stress and reduced antioxidant status were observed in AD Tg mice. 4% figs treated AD Tg mice significantly attenuated oxidative damage, as evident by decreased lipid peroxidation and protein carbonyls and restoration of antioxidant status. Altered activities of membrane bound enzymes (Na+ K+ ATPase and acetylcholinesterase (AChE)) in AD Tg mice brain regions and was restored by figs treatment. Further, figs supplementation might be able to decrease the plasma levels of Aβ (1–40, 1–42) significantly in Tg mice suggesting a putative delay in the formation of plaques, which might be due to the presence of high natural antioxidants in figs. But this study warrants further extensive investigation to find a novel lead for a therapeutic target for AD from figs.

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Section: Discussionsupporting

confidence: 68%

“…Figs supplementation to AD Tg mice was able to reverse the decrease in GSH levels. Aziz [55] has reported that figs could be able to reverse the GSH levels in lead acetate and carbon tetrachloride induced hepatotoxicity [52] in rats, suggesting the efficacy of figs in preventing the oxidative damage and associated changes.…”

Section: Discussionmentioning

confidence: 99%

Chronic Dietary Supplementation of 4% Figs on the Modification of Oxidative Stress in Alzheimer’s Disease Transgenic Mouse Model

Subash

Essa

Al‐Asmi

et al. 2014

BioMed Research International

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“…Pretreatment with cyanidin-3-rhamnoglucoside inhibited proapoptotic processes that were initiated by the oxidation of lysosome membranes in fibroblast cells [94]. Methanol leaf extracts of Ficus carica (150 mg/kg) also showed antioxidant and hepatoprotective activity in hepatotoxicity induced in rats by carbon tetrachloride [95]. The methanol extracts of Ficus carica leaves were screened for in vitro antioxidant activities using 2,2-diphenyl-1-picrylhydrazyl (DPPH).…”

Section: Antioxidant Effectmentioning

confidence: 99%

Nutritional and pharmacological importance of Ficus carica - A review

Al-Snafi¹

2017

IOSRPHR

124

111

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Abstract:-The preliminary phytocemical analysis showed that the fruits of Ficus carica contained alkaloids, tannins, glycosides, flavanoids, saponins, coumarins, sterols, terpenes carbohydrates, phenols, essential oil, volatile oil, proteins and minerals. The previous pharmacological studies revealed that Ficus carica possessed antibacterial, antiviral, antiparasitic, antioxidant, anticancer, antimutagene, anti-angiogenic, antiinflammatory, antipyretic, antidiabetic, antiplatelet, reproductive, endocrine, immunological, dermatological, hypolipidemic, nootropic, antispasmodic, antidiarrheal, anti-warts, nephro-and hepato-protective effects. The current paper reviewed the chemical constituents, nutritional and pharmacological importance of Ficus carica.

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“…Thus, the extract protects against TAM-induced hepatocyte injury indicating the ability to stabilize the liver cell membranes [29]. The significant increase in hepatic LPO as assessed by the high level of TBARS explains the observed leakage of cellular ALT and AST into the circulation, which suggests hepatocellular damage.…”

Section: Effec On Tnfmentioning

confidence: 89%

Hepatoprotective, Antihyperglycemic and Cytotoxic Activities of Jacaranda acutifolia Leaf Extract

Jamie¹,

Alshami²,

Maliabari³

et al. 2017

Med Aromat Plants

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Objective: Leaves methanol extract of Jacaranda acutifolia Humb. and Bonpl. (JA) family Bignoniaceae was subjected to phytochemical investigation as well as antioxidant, hepatoprotective, cytotoxic and antihyperglycemic activities evaluation.Key findings: Eight compounds were identified: luteolin-7-O-β-D-glucuronide, luteolin-7-O-β-D-glucoside, aesculetin, luteolin, verbascoside, luteolin-7-O-β-D-glucuronide methyl ester, apigenin-7-O-β-D-glucuronide methyl ester and apigenin. JA revealed a potent antioxidant activity in vitro superior to vitamin E (DPPH assay; EC 50 of 0.43 mg/mL). A potential cytotoxic activity was produced against hepatocellular (HepG2) and cervical (HeLa) carcinoma cells with IC 50 of 6.05 and 16.7 µg, respectively. Treatment with JA extract inhibited the rise in alanine aminotransferase and aspartate aminotransferase by 33.6% and 36.8% respectively, reduced thiobarbituric acid by 35.7% and decreased the tamoxifen-induced elevation in tumor necrosis factor alpha (TNF-α) level by 42.86%. JA extract elicited a significant decrease in fasting blood glucose by -59.26%. Conclusions:Jacaranda acutifolia could be a natural source for antioxidant, hepatoprotective supplements and could provide a basis for a potential cytotoxic agent. The compounds isolated are responsible at least in part for the observed effects.

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Antioxidant and hepatoprotective activities of Egyptian moraceous plants against carbon tetrachloride-induced oxidative stress and liver damage in rats

Cited by 54 publications

References 66 publications

Chronic Dietary Supplementation of 4% Figs on the Modification of Oxidative Stress in Alzheimer’s Disease Transgenic Mouse Model

Chronic Dietary Supplementation of 4% Figs on the Modification of Oxidative Stress in Alzheimer’s Disease Transgenic Mouse Model

Nutritional and pharmacological importance of Ficus carica - A review

Hepatoprotective, Antihyperglycemic and Cytotoxic Activities of Jacaranda acutifolia Leaf Extract

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