Hepatoprotective and anti-inflammatory activities of Ballota glandulosissima

Özbek, Hanefí; Çitoğlu, Gülçin Saltan; Dülger, Haluk; Uğraş, Serdar; Sever, Betül

doi:10.1016/j.jep.2004.06.030

Cited by 16 publications

(12 citation statements)

References 14 publications

(15 reference statements)

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“…The water extract was prepared by macerating 20 g of plant powder in cold distilled water (300 mL) for one day. The macerate was evaporated and lyophillized (7,8). The yield was 20 % (w/w).…”

Section: Preparation Of Extractmentioning

confidence: 99%

Analgesic and hepatoprotective effects of chelidonium majus l. : chelidonium majus l.’un analjezik ve hepatoprotektif etkileri

Yılmaz¹

2007

Ankara Universitesi Eczacilik Fakultesi Dergisi

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Water extract of Chelidonium majus L. (CM) was investigated for analgesic effect in mice and hepatoprotective effect in rats.Analgesic activity of the extract was tested using tail-flick test. Mice were injected CM intraperitoneally (i.p.) in doses of 50 mg/kg, 100 mg/kg and 200 mg/kg. Pain tresholds were measured with tail-flick test before administration and at 30 th , 90 th and 150 th minutes after treatment. Hepatoprotective activity of CM on carbon tetrachloride (CCl 4 ) induced acute liver toxicity was also studied. Rats were injected CM i.p. in doses of 100 mg/kg and 200 mg/kg. CM had no analgesic activity at 50 and 100 mg/kg doses. However at 200 mg/kg dose, it produced higher analgesic activity than aspirin at 90 th minute. At the 150 th minute, its analgesic activity was equal to that of aspirin. CM (100 mg/kg and 200 mg/kg) showed no significant influence on the increased levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and bilirubine in CCl 4 treated Betül SEVER YILMAZ, Hanefi ÖZBEK, Gülçin SALTAN ÇİTOĞLU, Serdar UĞRAŞ, İrfan BAYRAM, Ender ERDOĞAN 10 animals. Histopathological examination did not reveal any significant difference between CM (100 mg/kg) and CCl 4 groups. The results of this study clearly indicate that C. majus. has analgesic activity at 200 mg/kg dose in mice. However C. majus. has no hepatoprotective effect against carbon tetrachloride-induced liver toxicity in rats.

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Section: Preparation Of Extractmentioning

confidence: 99%

Analgesic and hepatoprotective effects of chelidonium majus l. : chelidonium majus l.’un analjezik ve hepatoprotektif etkileri

Yılmaz¹

2007

Ankara Universitesi Eczacilik Fakultesi Dergisi

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“…The aqueous extract was prepared by macerating 20 g of powder in cold distilled water (300 mL) for 1 day. The macerate was evaporated and lyophilized (Kouadio et al, 2000;Özbek et al, 2004).…”

Section: Preparation Of Extractmentioning

confidence: 99%

Analgesic and hepatotoxic effects of Ononis spinosa L.

Yilmaz

Özbek

Çitoğlu

et al. 2006

Phytotherapy Research

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The present study investigated the analgesic and hepatoprotective activities of a water extract of Ononis spinosa L. (OS) in mice. Analgesic activity was based on the pain thresholds measured with the tail-flick test before administration at 30, 90 and 150 min. The results were analysed with one-way variance analysis. The extract of Ononis spinosa showed analgesic activity equivalent to aspirin at 30 and 90 min and even higher than aspirin with the 50 mg/kg dose. At a dose of 100 mg/kg OS showed an analgesic effect equivalent to aspirin at all time points.The hepatoprotective influence of OS on carbon tetrachloride (CCl(4))-induced acute liver toxicity was also studied. The extract had no significant effect on the increased levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and bilirubin in CCl(4) treated animals (p > 0.05). Thus, the results reveal that the extract of OS had no hepatoprotective effect on CCl(4)-induced acute liver toxicity.

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Section: 972mentioning

confidence: 99%

“…The antimicrobial activities [4] and the antioxidant activities [5] of all Ballota species growing in Turkey was recently reported as well as the antifungal activities of some flavonoids isolated from B. glandulossima [6] and B. inaequidens [7]. The water extract of B. glandulosissima has been reported to have antinociceptive [8], antiinflammatory, and hepatoprotective activities [9].Previous investigations of the aerial parts of the Ballota species resulted in the isolation of some flavonoids apigenin and apigenin-7-glucoside [10,11]; kumatakenin, ladanein [10]; genkwanin, nuchensin, isokaempferide, luteolin, luteolin-7-rutinoside, quercetin-3-glycoside, salvigenin, apigenin 6,8-di-C-glycoside [10]; luteolin-7-glycoside [10]; scutallerein-7,4′-dimethylether, acacetin-7-glycoside, chrysoeriol-7-glycoside [10], luteolin-7-lactate, and luteolin-7-glycosyl lactate [12].In our previous studies, three diterpenoids (hispanolone, ballonigrine, dehydrohispanolone) and ten flavonoids (kumatakenin, pachypodol, 5-hydroxy-7,3′,4′-trimethoxyflavone, velutin, corymbosine, 5-hydroxy-3,7,4′-trimethoxyflavone, retusin, 5-hydroxy-7,4′-dimethoxyflavone, 5-hydroxy-3,6,7,4′-tetramethoxyflavone, ladanein) were isolated, chemically characterized, and analyzed by HPLC in different species of Ballota [6,7,13,14].Thus, as a continuation of our research [3-9, 13-15] on this genus we now report on the flavonoids present in the acetone extracts from sixteen species of the genus Ballota. Our aim is to contribute to their chemotaxonomic determination and establish the flavonoid profiles of Ballota species.…”

mentioning

confidence: 99%

High performance liquid chromatographic analysis of some flavonoids of Ballota species

Yılmaz

Çitoğlu

2006

Chem Nat Compd

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547.972Ballota L. is a plant belonging to the Lamiaceae family and is represented by 16 taxa in Turkey [1]. Ballota species have been used in Turkish folk medicine as an antiulcer, antispasmodic, diuretic, choleretic, antihaemorrhoidal, and sedative agents [2,3]. The antimicrobial activities [4] and the antioxidant activities [5] of all Ballota species growing in Turkey was recently reported as well as the antifungal activities of some flavonoids isolated from B. glandulossima [6] and B. inaequidens [7]. The water extract of B. glandulosissima has been reported to have antinociceptive [8], antiinflammatory, and hepatoprotective activities [9].Previous investigations of the aerial parts of the Ballota species resulted in the isolation of some flavonoids apigenin and apigenin-7-glucoside [10,11]; kumatakenin, ladanein [10]; genkwanin, nuchensin, isokaempferide, luteolin, luteolin-7-rutinoside, quercetin-3-glycoside, salvigenin, apigenin 6,8-di-C-glycoside [10]; luteolin-7-glycoside [10]; scutallerein-7,4′-dimethylether, acacetin-7-glycoside, chrysoeriol-7-glycoside [10], luteolin-7-lactate, and luteolin-7-glycosyl lactate [12].In our previous studies, three diterpenoids (hispanolone, ballonigrine, dehydrohispanolone) and ten flavonoids (kumatakenin, pachypodol, 5-hydroxy-7,3′,4′-trimethoxyflavone, velutin, corymbosine, 5-hydroxy-3,7,4′-trimethoxyflavone, retusin, 5-hydroxy-7,4′-dimethoxyflavone, 5-hydroxy-3,6,7,4′-tetramethoxyflavone, ladanein) were isolated, chemically characterized, and analyzed by HPLC in different species of Ballota [6,7,13,14].Thus, as a continuation of our research [3-9, 13-15] on this genus we now report on the flavonoids present in the acetone extracts from sixteen species of the genus Ballota. Our aim is to contribute to their chemotaxonomic determination and establish the flavonoid profiles of Ballota species. To our knowledge, no data are available with respect to the chemotaxonomic determination and HPLC analysis of this genus.

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Hepatoprotective and anti-inflammatory activities of Ballota glandulosissima

Cited by 16 publications

References 14 publications

Analgesic and hepatoprotective effects of chelidonium majus l. : chelidonium majus l.’un analjezik ve hepatoprotektif etkileri

Analgesic and hepatoprotective effects of chelidonium majus l. : chelidonium majus l.’un analjezik ve hepatoprotektif etkileri

Analgesic and hepatotoxic effects of Ononis spinosa L.

High performance liquid chromatographic analysis of some flavonoids of Ballota species

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