Hepatoprotective activity of Spillanthes acmella Extracts against CCl4-induced liver toxicity in rats

Rao, Battu Ganga; Rao, Yanghui; Talluri, Mallikarjuna Rao

doi:10.1016/s2222-1808(12)60153-4

Cited by 13 publications

(9 citation statements)

References 8 publications

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“…Most of these procedures require a long extraction time or the use of specialized equipment. Moreover, in most cases, authors focus on studying the biological activity of A. oleracea extracts, without assessing the main active ingredient (spilanthol) content in the crude or final extract, meaning optimized extraction protocols have not been made available [3,10,27,[29][30][31][32][33][34][35][36][37][38][39].…”

Section: Resultsmentioning

confidence: 99%

Extraction, Purification, Quantification, and Stability of Bioactive Spilanthol from Acmella oleracea

et al. 2022

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Acmella oleracea is an ethnobotanically significant plant with a relatiwely high content of spilanthol. Due to its broad spectrum of activity, including anti-inflammatory, antioxidant, analgesic, antifungal, and bacteriostatic properties, it is considered a valuable bioactive natural product. In addition, spilanthol as its main bioactive component inhibits facial muscle contractions, making it an attractive ingredient in anti-wrinkle and anti-aging cosmetics. Due to its muscle paralyzing effects, it is called herbal botox. The commercial interest in spilanthol encourages the development of effective methods of isolating it from plant material. The methodology used in this paper allows for the obtaining of extracts from Acmella oleracea with a relatively high content of spilanthol. An effective method of spilanthol extraction from all aerial parts of Acmella oleracea as well as methods of enriching spilanthol concentration in extracts achieved by removing polar and acidic substances from crude extracts was developed. To quantify the concentration of spilanthol, a simple, fast and economically feasible quantification protocol that uses nuclear magnetic resonance (HNMR) was developed. In addition, it has been proven, that oxidation of spilanthol by air gives (2E,7Z)-6,9-endoperoxy-N-(2-methylpropyl)-2,7-decadienamide. The studies on spilanthol solutions stability were carried out and the conditions for the long-time storage of spilanthol solutions have also been developed. Additionally, for confirmation of obtained results a sensitive (LOQ=1 ng/mL), precise (RSD lower than 7%) and accurate (RE lower than 7.5%), new HPLC-MS/MS method was applied.

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Section: Resultsmentioning

confidence: 99%

Extraction, Purification, Quantification, and Stability of Bioactive Spilanthol from Acmella oleracea

et al. 2022

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“…Total flavonoid concentration was determined using a modified calorimetric method 36 . Following the protocol of 37 the alkaloid content was determined.…”

Section: Determination Of Total Phenol Contentmentioning

confidence: 99%

Evaluation of Secondary Metabolites of Ageratina adenophora and Synthesis of Silver Nanoparticles for its Antibacterial and Antioxidant Activity

Maheswari¹,

N²,

N³

et al. 2023

Orient. J. Chem

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Synthetic antibiotics have been successfully utilized for decades against pathogenic bacteria to control infectious diseases. However, the continuous and overuse has resulted in multidrug resistant (MDR) bacterial species. Further, the negative side effects caused by commercial antibiotics also hindered their usage. The phytochemicals produced by plants in response to adverse biotic and abiotic conditions possess significant pharmacological properties and can be an effective alternative to synthetic antibiotics. The phytochemicals of Ageratinaadenophora, served the role of reducing and stabilizing agent. Ageratinaadenophora mediated silver nanoparticles (Aa-AgNPs) were characterized using advanced spectroscopic instrumentation. The qualitative analysis by GC-MS showed Methyl ionone, 2(3H)-Naphthalenone, 4, 4a, 5, 6, 7, 8- hexahydro-4a,7,7-trimethyl-(R), Isolongifolone as the major compounds. The quantitative estimation showed leaves were rich in total phenol, flavonoids, alkaloids and tannins. The Aa-AgNPs were effective in inhibiting bacterial pathogens. Further, A.adenophora mediated nanoparticles possessed strong antioxidant activity.

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“…Home grown medications are all the more broadly utilized for hepatoprotectives. Hepatoprotective movement of S.acmella extricates against CCl4-instigated liver harmfulness in rodents was resolved [32,33] .…”

Section: Hepatoprotective Activitymentioning

confidence: 99%

An Overview on Spilanthues Acmella

Khan¹,

Abid²

2020

IJAR

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Hepatoprotective activity of Spillanthes acmella Extracts against CCl4-induced liver toxicity in rats

Cited by 13 publications

References 8 publications

Extraction, Purification, Quantification, and Stability of Bioactive Spilanthol from Acmella oleracea

Extraction, Purification, Quantification, and Stability of Bioactive Spilanthol from Acmella oleracea

Evaluation of Secondary Metabolites of Ageratina adenophora and Synthesis of Silver Nanoparticles for its Antibacterial and Antioxidant Activity

An Overview on Spilanthues Acmella

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