Objective: To evaluate anti-arthritic potential of methanolic extract of rhizome of Costus speciosus Koen. Methods: The powdered drug was extracted with 80% methanol. The crude extract was subjected to phytochemical investigation and was evaluated for its anti-arthritic potential by freund's complete adjuvant induced arthritis model in adult wistar albino rats. Determination of different parameters like arthritic score, arthritic index, paw thickness, body weight, and pain, altered liver enzymes and biochemical estimation like, nitric oxide level and Plasma TNF-α level was done. Finally, radiological estimation and histopathology of tibio tarsal joints was performed. Statistical analysis was performed using one way ANOVA followed by Dunnet's test at different p-values. Results: Phytochemical study revealed the presence of flavonoids, phenolic compound, saponins and carbohydrates. For different parameter mentioned above, anti-arthritic activity shown by prophylactic high dose test extract (200 mg/kg) was as potent as standard drug Indomethacin (10 mg/kg). The effect of Prophylactic low dose extract (100 mg/kg) and therapeutic high dose extract (200 mg/kg) was less than that of Indomethacin (10 mg/kg). Furthermore, Therapeutic low dose extract (100 mg/kg) was not effective. Conclusions: The obtained results indicate that Costus speciosus rhizome extract possess significant anti-arthrtic potential.
Objective: The research work deals with the screening of hydroalcoholic extract of Amaranthus tricolor (HAEATL) leaves for central nervous system activity (anti-stress, nootropic, and anti-cataleptic activity).
Methods: The screening of scopolamine and different model-induced neurodisorder rats were treated with 200 and 400 mg/kg body weight dose of hydroalcoholic extract of A. tricolor lives in 7 days’ experimental schedule. It has been reported that the antioxidant, hepatoprotective, hematological, and antimicrobial activities.
Results: The result of the study reflected that HAEATL (200 and 400 mg/kg) was effective in all methods and showed anti-stress, nootropic, and anti-cataleptic activity in a dose-dependent manner. The results are represented that the HAEATL produce the significant decreased the swimming time, increased the anoxia time, decreased level of biochemical parameters such as glucose and cholesterol except blood urea nitrogen, decreased level of white blood cell and red blood cell, and more significantly decreased the catalepsies score on 7th day compared to the control group.
Conclusion: The above valuable animal study, we concluded that the HAEATL showing significantly affect compeer to the disease control group on neuroprotective activity.
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