Hepatocyte Growth Factor as a Prognostic Marker in Heart Failure: Promise and Challenges

Fountoulaki, Katerina; Parissis, John

doi:10.1159/000338158

Cited by 3 publications

(3 citation statements)

References 51 publications

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“…Through its natural receptor c-Met, HGF is now known to promote matrix invasion, angiogenesis, tumorigenesis, and tissue regeneration (7,8,(62)(63)(64). HGF has been previously shown to promote cell motility in several normal and cancer cell lines (8, 10, 44, 48, 63, 65).…”

Section: Discussionmentioning

confidence: 99%

Role of c-Met/Phosphatidylinositol 3-Kinase (PI3k)/Akt Signaling in Hepatocyte Growth Factor (HGF)-mediated Lamellipodia Formation, Reactive Oxygen Species (ROS) Generation, and Motility of Lung Endothelial Cells

Usatyuk

Mohan

et al. 2014

Journal of Biological Chemistry

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Background: Lamellipodia structures provide a platform for the spatio-temporal localization of key components necessary for cell migration. Results: HGF activates c-Met/PI3k/Akt signaling axis, which is essential for the recruitment of actin, cortactin, p47phox , and Rac1and ROS production in lamellipodia. Conclusion: HGF-induced spatio-temporal localization of cytoskeletal proteins and NADPH oxidase components regulate lamellipodial ROS and cell migration. Significance: This study identifies a novel role for lamellipodial ROS in cell motility.

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Section: Discussionmentioning

confidence: 99%

Role of c-Met/Phosphatidylinositol 3-Kinase (PI3k)/Akt Signaling in Hepatocyte Growth Factor (HGF)-mediated Lamellipodia Formation, Reactive Oxygen Species (ROS) Generation, and Motility of Lung Endothelial Cells

Usatyuk

Mohan

et al. 2014

Journal of Biological Chemistry

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“…HGF would be a magnetic biochemical marker in congested HF subjects therefore it is augmented in the circumstance of cardiac muscle cell apoptosis and active tissue repair, whereby ascertaining patients that are at elevated hazard of harmful clinical results. Nevertheless, based off of obtainable proof, the the heart disorder pathogenesis should be assumed before utilizing HGF as a biochemical marker [48] .…”

Section: Hgf and CI And Cadmentioning

confidence: 99%

Hepatocyte growth factor, a biomarker of macroangiopathy in diabetes mellitus

Konya

Miuchi

Satani

et al. 2014

WJD

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Atherosclerotic involvements are an essential causal element of prospect in diabetes mellitus (DM), with carotid atherosclerosis (CA) being a common risk-factor for prospective crisis of coronary artery diseases (CAD) and/or cerebral infarction (CI) in DM subjects. From another point of view, several reports have supplied augmenting proof that hepatocyte growth factor (HGF) has a physiopathological part in DM involvements. HGF has been a mesenchymal-derived polyphenic factor which modulates development, motion, and morphosis of diverse cells, and has been regarded as a humor intermediator of epithelial-mesenchymal interplays. The serum concentrations of HGF have been elevated in subjects with CAD and CI, especially during the acute phase of both disturbances. In our study with 89 type 2 DM patients, the association between serum concentrations of HGF and risk-factors for macrovascular complications inclusive of CA were examined. The average of serum HGF levels in the subjects was more elevated than the reference interval. The serum HGF concentrations associated positively with both intimal-media thickness (IMT) (r = 0.24, P = 0.0248) and plaque score (r = 0.27, P = 0.0126), indicating a relationship between the elevated HGF concentrations and advancement of CA involvements. Multivariate statistical analysis accentuated that serum concentrations of HGF would be associated independently with IMT (standardized = 0.28, P = 0.0499). The review indicates what is presently known regarding serum HGF might be a new and meaningful biomarker of macroangiopathy in DM subjects.

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“…However, based on available evidence, the etiology of cardiac abnormality has to be considered before applying HGF as a biomarker [51].…”

Section: Hgf As a Biomarker Of Cardiac Damagementioning

confidence: 99%

Potential Target Molecules in Diabetic Cardiomyopathy: Hepatocyte Growth Factor (HGF) and Ryanodine Receptor 2 (RyR2)

Klimas¹

2013

Cardiomyopathies

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Hepatocyte Growth Factor as a Prognostic Marker in Heart Failure: Promise and Challenges

Cited by 3 publications

References 51 publications

Role of c-Met/Phosphatidylinositol 3-Kinase (PI3k)/Akt Signaling in Hepatocyte Growth Factor (HGF)-mediated Lamellipodia Formation, Reactive Oxygen Species (ROS) Generation, and Motility of Lung Endothelial Cells

Role of c-Met/Phosphatidylinositol 3-Kinase (PI3k)/Akt Signaling in Hepatocyte Growth Factor (HGF)-mediated Lamellipodia Formation, Reactive Oxygen Species (ROS) Generation, and Motility of Lung Endothelial Cells

Hepatocyte growth factor, a biomarker of macroangiopathy in diabetes mellitus

Potential Target Molecules in Diabetic Cardiomyopathy: Hepatocyte Growth Factor (HGF) and Ryanodine Receptor 2 (RyR2)

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