Potential Target Molecules in Diabetic Cardiomyopathy: Hepatocyte Growth Factor (HGF) and Ryanodine Receptor 2 (RyR2)

Klimas, Ján

doi:10.5772/55780

Cited by 1 publication

(3 citation statements)

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“…and suppressor (hyperglycemia, TGF-, Ang Ⅱ, etc.) ( Figure 6) [8,19] . Accordingly, the increase of the serum HGF level might be regarded as an indicator of the DM involvements severeness.…”

Section: Resultsmentioning

confidence: 99%

“…General HGF might affect in anagenesis as a humor intermediator, nevertheless it might be deficient to accelerate anagenesis, due to a decrement in regional HGF generation. Finally, the HGF/ MET signalling would play an essential part in heart injury for example DM cardiac myopathy and precise discrimination of this part might ask for a new directions for agent exploitation and to assist better prospective DM care [8] .…”

Section: Hgf and Dm Cardiac Myopathymentioning

confidence: 99%

“…It suggests a distinct timecourse of DM endorgan disorder. Therefore, in a differential manner, respective cell types would be exact to hyperglycemia-caused disturbance possibly for sake of distinct expression or activeness of molecular factors would be in charge of damage activating and progression [8] .…”

Section: Introductionmentioning

confidence: 99%

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Hepatocyte growth factor, a biomarker of macroangiopathy in diabetes mellitus

Konya

Miuchi

Satani

et al. 2014

WJD

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Atherosclerotic involvements are an essential causal element of prospect in diabetes mellitus (DM), with carotid atherosclerosis (CA) being a common risk-factor for prospective crisis of coronary artery diseases (CAD) and/or cerebral infarction (CI) in DM subjects. From another point of view, several reports have supplied augmenting proof that hepatocyte growth factor (HGF) has a physiopathological part in DM involvements. HGF has been a mesenchymal-derived polyphenic factor which modulates development, motion, and morphosis of diverse cells, and has been regarded as a humor intermediator of epithelial-mesenchymal interplays. The serum concentrations of HGF have been elevated in subjects with CAD and CI, especially during the acute phase of both disturbances. In our study with 89 type 2 DM patients, the association between serum concentrations of HGF and risk-factors for macrovascular complications inclusive of CA were examined. The average of serum HGF levels in the subjects was more elevated than the reference interval. The serum HGF concentrations associated positively with both intimal-media thickness (IMT) (r = 0.24, P = 0.0248) and plaque score (r = 0.27, P = 0.0126), indicating a relationship between the elevated HGF concentrations and advancement of CA involvements. Multivariate statistical analysis accentuated that serum concentrations of HGF would be associated independently with IMT (standardized = 0.28, P = 0.0499). The review indicates what is presently known regarding serum HGF might be a new and meaningful biomarker of macroangiopathy in DM subjects.

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Section: Resultsmentioning

confidence: 99%

Section: Hgf and Dm Cardiac Myopathymentioning

confidence: 99%