Hepatocurative and antioxidant profile of HP-1, a polyherbal phytomedicine

Tasaduq, S A; Singh, Kuldip; Sethi, Sonali; Sharma, S. C.; Bedi, K. L.; Singh, Jaswant; Jaggi, B.S; Johri, R.K.

doi:10.1191/0960327103ht406oa

Cited by 58 publications

(40 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Protective effects of an aqueous extract of T. chebula fruit on the tert-butyl hydroperoxide-induced oxidative injury was observed in cultured rat primary hepatocytes and rat liver have also been documented [28,29] . T. chebula in a herbal formulation showed hepatoprotective activity against carbon tetrachloride induced toxicity in rat hepatocytes [38] .…”

Section: Hepatoprotective Activitymentioning

confidence: 97%

“…F rom the literature it has been noted that T. chebula exhibited significant hepatoprotective [36][37][38] , cardioprotective [39,40] , antimutagenic/anticarcinogenic [31-3 3 ] , c y t o p r o t e c t i v e [ 4 1 -4 4 ] , a n t i o x i d a n t [ 2 4 -3 0 ] a n d adaptogenic [77,78] effects. Aqueous, ethanol, and ethyl acetate extracts of T. chebula fruits also demonstrated no cellular toxicity on sheep erythrocytes as well as acute oral toxic effects on rats at recommended and higher doses [48,91,92] .…”

Section: Safety Evaluationmentioning

confidence: 99%

See 1 more Smart Citation

The development of Terminalia chebula Retz. (Combretaceae) in clinical research

Bag

Bhattacharyya

Chattopadhyay

2013

Asian Pacific Journal of Tropical Biomedicine

253

180

View full text Add to dashboard Cite

Section: Hepatoprotective Activitymentioning

confidence: 97%

Section: Safety Evaluationmentioning

confidence: 99%

The development of Terminalia chebula Retz. (Combretaceae) in clinical research

Bag

Bhattacharyya

Chattopadhyay

2013

Asian Pacific Journal of Tropical Biomedicine

253

180

View full text Add to dashboard Cite

“…Liv-52 was used as a positive control at a dose level of 250 μL/mL. All the substances were dissolved in DMSO [29] .…”

Section: In-vitro Hepatoprotective Activitymentioning

confidence: 99%

Hepatoprotective evaluation of Anogeissus latifolia: In vitro and in vivo studies

Pradeep¹,

Khan²,

Ravikumar³

et al. 2009

WJG

View full text Add to dashboard Cite

AIM:To evaluate the hepatoprotective activity of a hydroalcoholic extract of the bark of Anogeissus latifolia ; in vitro in primary rat hepatocyte monolayer culture and in vivo in the liver of Wistar rats intoxicated by carbon tetrachloride (CCl4). METHODS:In the in vitro study, a primary hepatocyte monolayer culture was treated with CCl4 and extract of Anogeissus latifolia . Hepatoprotective activity was demonstrated in the CCl4 damaged primary monolayer culture. In the in vivo study, the hepatoprotective activity of a hydroalcoholic extract of Anogeissus latifolia was analyzed in liver injured CCl4-treated rats. Biochemical parameters including serum transaminases [aspartate aminotransferase (AST) and alanine aminotransferase (ALT)] and alkaline phosphatase (ALP) in serum were analyzed. The biochemical findings were supplemented with histopathological examination of rat liver sections.

show abstract

“…For example, Phyllanthus amarus (synonym: Phyllanthus niruri) reduced oxidative damage from radiation 19) and protected against hepatotoxicity induced by CCl 4 . 20) Phyllanthus emblica protected rat hearts from oxidative stress induced by ischemic-reperfusion injury. 21) Phyllanthus urinaria L. is another medicinal plant that has attracted research attention in the treatment of several diseases.…”

mentioning

confidence: 96%

Antioxidative and Cardioprotective Effects of Phyllanthus urinaria L. on Doxorubicin-Induced Cardiotoxicity

Chularojmontri

Wattanapitayakul

Herunsalee

et al. 2005

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

Doxorubicin (DOX) is an effective and broadly used agent to treat a variety of malignacies, such as leukemias, breast and ovarian cancer, and Hodgkin and non-Hodgkin lymphoma. The major limitation of clinical use is the development of cardiotoxicity. The adverse effects are dose dependent and can vary from transient electrocardiographic abnormalities to cardiomyopathy and heart failure. Recent studies have suggested that the mechanism of DOX-induced cardiotoxicity involves the generation of reactive oxygen species (ROS), especially superoxide anion and hydrogen peroxide.1-3) The main cellular damage caused by ROS includes lipid peroxidation, protein cross-linking, and DNA fragmentation. These may lead to cardiac dysfunction, apoptosis, and development of cardiomyopathy. 4-7)Although protection or alleviation of DOX toxicity can be achieved by administration of antioxidant vitamins such as ascorbic acid and vitamin E, their cardioprotective effects remain controversial. [8][9][10] It is well established that there is no universal "best" antioxidant. For example, ascorbic acid efficiently protects against lipid damage but not against protein damage.11) Thus alternative naturally occurring antioxidants may potentially be candidates for antioxidant therapy.It has been shown in many studies that traditionally used plant extracts protect against oxidative damage caused by a wide array of insults including DOX.12-16) Among traditional herbs, Phyllanthus spp. (Euphorbiaceae) has been used in Aryuvedic medicine for more than 2000 years and in Thai folk medicine for the treatment of many diseases, such as diarrhea, hepatitis, diabetes, abdominal pain, and kidney disease. 17,18) The antioxidant effects of plant species in the genus Phyllanthus have been reported. For example, Phyllanthus amarus (synonym: Phyllanthus niruri) reduced oxidative damage from radiation 19) and protected against hepatotoxicity induced by CCl 4 . 20) Phyllanthus emblica protected rat hearts from oxidative stress induced by ischemic-reperfusion injury.21) Phyllanthus urinaria L. is another medicinal plant that has attracted research attention in the treatment of several diseases. Substantial progress in determining its phytochemical and pharmacologic properties has been made. Several potential antioxidant compounds (e.g., polyphenols, lignans, flavonoids, gallic acid, ellagic acid, etc.) have been isolated from this plant. [22][23][24][25][26] However, to the best of our knowledge, there has been no report on the potential antioxidant effects of Phyllanthus urinaria. Therefore the purpose of this study was to investigate the antioxidant effects of Phyllanthus urinaria for the protection of cardiac cells from DOX cardiotoxicity. Cardiac toxicity is a major adverse effect caused by doxorubicin (DOX) therapy. Many recent studies have shown that DOX toxicity involves generation of reactive oxygen species (ROS). Although protection or alleviation of DOX toxicity can be achieved by administration of antioxidant vitamins such as ascorbic acid and vitamin ...

show abstract

Hepatocurative and antioxidant profile of HP-1, a polyherbal phytomedicine

Cited by 58 publications

References 22 publications

The development of Terminalia chebula Retz. (Combretaceae) in clinical research

The development of Terminalia chebula Retz. (Combretaceae) in clinical research

Hepatoprotective evaluation of Anogeissus latifolia: In vitro and in vivo studies

Antioxidative and Cardioprotective Effects of Phyllanthus urinaria L. on Doxorubicin-Induced Cardiotoxicity

Contact Info

Product

Resources

About