HP-1 a herbal formulation comprising of Phyllanthus niruri and extracts of Terminalia belerica, Terminalia chebula, Phyllanthus emblica and Tinospora cordifoliahas been evaluated for hepatoprotective activity against carbon tetrachloride (CCl4) induced toxicity. Results show that HP-1 reversed the leakage of lactate dehydrogenase (LDH) and glutamate pyruvate transaminase (GPT) and prevented the depletion of glutathione (GSH) levels in a primary monolayer culture of rat hepatocytes (in vitro). HP-1 attenuated the serum toxicity as manifested in elevated levels of transaminases (glutamate oxaloacetate transaminase (GOT), and GPT) The anti-oxidative enzymes in liver (catalase and superoxide dismutase (SOD)) were restored to normal values after the oral administration of HP-1. HP-1 suppressed the formation of the superoxide anion radical and reduced CCl4 mediated lipid peroxidation (LPO). Silymarin and antioxidants (ascorbic acid,β-carotene and tocopherol) were used for comparison. The present study showed that HP-1 is a potential hepatoprotective formulation with an additional attribute of being anti-peroxidative.
Myrica esculenta (Myricaceae) and Syzygium cumini(Myrtaceae), the Indian traditional fruits were studied for their biochemical assay, antifungal activity and mineral analysis. The biochemical assay in terms of total phenols, flavonols, ortho dihydroxy phenolic, ascorbic acid and phytic acid content and antioxidant activity revealed different quantitative make up in all the different samples. The in vitro antioxidant activity determined by reducing power assay, chelating power on Fe2+ ions and 2, 2-diphenylpicrylhydrazil (DPPH) radical scavenging activity were found to be good to moderate in a dose dependent manner in all the extracts. The extracts showed significant antinociceptive and antipyretic activity on mice. Methanolic extracts of both the fruits collected from different regions exhibited good antifungal activity against the three pathogenic fungi viz; Rhizoctonia solani, Sclerotium rolfsii, and Fusarium oxysporium. All the extracts studied for their mineral analysis through atomic absorption spectroscopy also revealed quantitative variation of N, P , K , S, Fe, Zn, Cu and Mn. Fe was found to be maximum in all the samples however Na was absent in all the samples.
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