Hepatocellular Carcinoma with Metastasis to the Spleen in a Holstein Cow

Jeong, Won–Il; Do, SH; Sohn, MH; Yun, Haiyang; Kwon, OD; Kim, Tae Hee; Jeong, DH; Williams, BH; Jeong, KS

doi:10.1354/vp.42-2-230

Cited by 10 publications

(14 citation statements)

References 9 publications

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“…All cattle affected in this study were adults, aged three years or older, similar to that reported by other authors (Anderson & Sandinson 1968, Wettimuny 1969, Braun et al 2005, Jeong et al 2005. Females were more affected than males, and, although few studies assessed a possible sex predilection for the development of liver tumors in cattle (Wettimuny 1969, Braun et al 2005, in dogs and cats it is known that there is no such predisposition (Patnaik et al 1981, Trigo et al 1982, Lawrence et al 1994, Liptak et al 2004, Flores et al 2013, Van Sprundel et al 2014.…”

Section: Discussionsupporting

confidence: 85%

Primary hepatic neoplasms in cattle

et al. 2020

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Primary hepatic neoplasms are mostly detected in cattle as incidental findings in slaughterhouses or diagnosed at the necropsy, wherein it may be related to the cause of death. A proper characterization of primary hepatic neoplasms is essential to provide an accurate diagnosis, especially at the slaughter lines, in order to reduce erroneous condemnations. This work aimed to characterize the gross, histological, and immunohistochemical features of primary liver neoplasms detected in slaughtered cattle in Southern Brazil. Nineteen primary hepatic neoplasms were identified. Grossly, these lesions were classified according to their distribution, as focal, multifocal, or diffuse. Histologically, the shape and arrangement of the cells, as well as possible malignant features were evaluated. Immunohistochemistry (IHC) was also performed for biliary epithelium (anti-CK7) and hepatocytes (anti-Hep Par-1) markers. Hepatocellular carcinoma (84.2%) was the most frequently detected hepatic neoplasm, followed by cholangiocarcinoma (15.8%), and these were only identified in adult cows. Hepatocellular carcinomas occurred as solitary masses or multifocal nodules, which on the cut surface were often green. Cholangiocarcinomas occurred as multifocal nodules, occasionally showing an umbilicated appearance. Histologically, hepatocellular carcinomas had mostly trabecular and solid patterns, while cholangiocarcinomas presented mostly a solid arrangement. Upon IHC, all hepatocellular carcinomas were immunolabeled for anti-Hep Par-1, ranging from mild (25%), moderate (31.2%) to marked (43.7%), while immunolabeling for anti-CK7 was detected only in one case of cholangiocarcinoma.

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Section: Discussionsupporting

confidence: 85%

Primary hepatic neoplasms in cattle

et al. 2020

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“…Unfortunately, a large part of the diagnosis of HCC in cattle is perfomed out postmortem, consisting mostly of incidental findings in the slaughterhouses [5,7,12], with few reports on the clinical conditional of the animal. Consistent with the scarce reports available in the literature [6,16], the main complaint of the owner of this report was progressive weight loss.…”

Section: Discussionmentioning

confidence: 99%

“…Although primary liver diseases are rare in farm animals, except for cases resultanting of intoxication [18], hepatocellular carcinoma (HCC) is the most frequent hepatic neoplasm in ruminants [15]. In cattle the reports are scarce [6,10,12], most of them coming from slaughterhouses, thus not allowing much data from HCC in this species [4,5,7,24].…”

Section: Introductionmentioning

confidence: 99%

Clinical - Pathological Aspects of Hepatocellular Carcinoma in Cattle

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et al. 2019

Acta Scientiae. Vet.

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Background:The hepatocellular carcinoma (HCC) is a malignant neoplasm of hepatocytes of rare occurrence in farm animals, with ruminants being the most affected species. This neoplasm is characterized by nonspecific symptoms and it is etiology in animals has not yet been fully elucidated, although aflatoxin has been shown to be a risk factor in the development this neoplasia. Since hepatic tumors in cattle are commonly incidental findings found in postmortem examination, the objective of this paper is to describe the clinical, laboratory and pathological findings in a cow with this neoplasm. Case: A 5-year-old, adult, Girolando cow weighing 350 kg was referred to the Veterinary Hospital of the Federal University of Recôncavo da Bahia, Brazil, with a history of decreased appetite and weakness for one month. The animal was raised in a semi-intensive system, with a corn-based diet, and regular vaccination. Futhermore, was not treated at the farm of origin and three days before being admitted to the hospital, began to present edema of the dewlap. On examination at our center, the cow was in lean, active, with mucupurulent secretion in nostrils; ocular conjunctiva edema; and edema of the dewlap. The cow had neutrophilia, hypofibrinogemia, hypoproteinemia, and trombocytopenia. It also had tachycardia, tense abdomen, engorgement of the vessels of the face and jugular veins, stasis test and bilaterally positive jugular pulse. Although evidence of pain in reticulum was negative in the examination, the initial diagnostic suspicion established was of traumatic reticular pericarditis. The therapeutic protocol instituted was daily monitoring, flunixin meglumine and flofernicol. The examination of rectal palpation revealed in the right flank an irregular-sized parenchymal structure with enlarged and palpacion in pain. Thus, by location and texture, it was suspected that the structure in question was a liver or kidney. However, the dosage of creatinine ruled out renal damage, and persistent hypoproteinemia reinforced the suspicion of hepatic impairment. In view the deterioration of the clinical condition and the suspicion of hepatic impairment, such as hepatic insufficiency, hepatitis or hepatic abscess, we opted for a right exploratory laparotomy. The surgery confirmed the presence of various granulomas throughout the liver, a non-luster organ, bulging edges with erosions and deposition of fibrin on the surface, confirming liver dysfunction. However, the animal died during the surgical procedure, and necropsy was performed, evidencing a focally extensive mass and multiple nodules of various sizes in the liver, lymph nodes and lung. In the microscopy of these nodules, cells similar to hepatocytes were observed, arranged in the form of strands or in agglomerates. Thus, similar to the reports in the literature, the diagnosis of HCC was carried out postmortem by necropsy and histopathology. Discussion: The diagnosis of HCC was based on clinical, laboratory and anatomopathological findings. The hypoproteinemia and persistent hypofib...

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“…A ocorrência de metástase nesta neoplasia é incomum, mas pode atingir 28% em gatos e 39% em bovinos, sendo mais frequentes em linfonodo, pulmão e peritônio no cão, e há relato de metástase no baço ,Cullen & Pop 2002, Jeong et al 2005. Contudo, no presente estudo observamos que haviam lesões nodulares no pâncreas e no rim na região córtico-medular, de distribuição multifocal, com características semelhantes às presentes no fígado, sugerindo que essas lesões eram metástases.…”

Section: Discussionunclassified

Carcinoma hepatocelular metastático em Jaguatirica (Leopardus pardalis )

et al. 2015

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RESUMO: O carcinoma hepatocelular (CHC) é uma neoplasia rara nos animais domésticos e em espécies selvagens foi relatado somente em antílopes, veado, cães da pradaria e furões, mas não existem relatos em Leopardus pardalis (jaguatirica). Este trabalho descreve um caso de carcinoma hepatocelular metastático em uma fêmea felina de aproximadamente 18 anos de idade, da espécie Leopardus pardalis, proveniente do Parque Zoobotânico de Teresina-PI, com histórico de anorexia, apatia e evolução ao óbito que foi encaminhada ao Setor de Patologia Animal da Universidade Federal do Piauí para exame anatomopatológico. À necropsia foram observadas duas nodulações de aproximadamente 8,0cm de diâmetro no fígado, de coloração variando da brancacenta ao vermelhado claro, amarelada a vermelho escuro, subdivididas em lóbulos por tecido conjuntivo. No pâncreas foram observadas múltiplas nodulações de aproximadamente 1,0 cm de diâmetro, com superfície lisa, consistência firme, coloração vermelho-amarelada. A superfície de corte dos rins também apresentava várias nodulações milimétricas de distribuição multifocal, na região córtico-medular, consistência firme, coloração branco-acinzentada ou amarelada, sugerindo metástase. Os fragmentos das lesões de fígado foram coletados e no exame microscópico observaram-se proliferação de hepatócitos em cordões bem diferenciados, formando trabéculas com espessura de três ou mais células. Os hepatócitos apresentavam-se volumosos, pleomórficos, com citoplasma eosinofílico. Na coloração com PAS constataram-se, regularmente, acúmulo de glicogênio nos hepatócitos neoplásicos. A confirmação foi feita pela técnica de imunoistoquímica, utilizando-se anticorpo monoclonal (Hepatocyte Specific Antigen). Os achados anatomohistopatológicos, e o auxilio da imunoistoquímica permitiram concluir pelo diagnóstico de hepatocarcinoma trabecular metastático em Leopardus pardalis criado em cativeiro.

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Hepatocellular Carcinoma with Metastasis to the Spleen in a Holstein Cow

Cited by 10 publications

References 9 publications

Primary hepatic neoplasms in cattle

Primary hepatic neoplasms in cattle

Clinical - Pathological Aspects of Hepatocellular Carcinoma in Cattle

Carcinoma hepatocelular metastático em Jaguatirica (Leopardus pardalis )

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