“…As indicated design, the PBMC treatment was able to significant induce the apoptosis of tumor cells, and the combination with ABHD5 gene therapy demonstrated a synergistic effect on cell viability inhibition. The major cells of PBMC are lymphocytes, which including T cells, B cells and NK cells, the PD-1 expressing T cells contribute to the immunosuppression of PD-L1 positive tumors ( Chinnadurai et al, 2021 ; Liang et al, 2022 ; Pisani et al, 2022 ). ABHD5 was downregulated in liver tumor and showed a negative regulation on PD-L1 expression.…”