Sustained release of therapeutic gene by injectable hydrogel for hepatocellular carcinoma

Xu, Shaohua; Cai, Jing; Cheng, Hongwei; Wang, Sheng

doi:10.1016/j.ijpx.2023.100195

Cited by 1 publication

(1 citation statement)

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“…They encapsulate the drug in their matrix, which allows the administration of the drug orally, topically, or parenterally, with specific, targeted properties with controlled or delayed release. This formulation increases the bioavailability of hydrophobic drugs and enables combining several compounds in one hydrogel matrix [25][26][27][28]. Considering the above-discussed properties of hydrogels, these matrices can be used as a promising delivery system for low soluble hydrophobic therapeutic agents such as curcumin.…”

Section: Hydrogelsmentioning

confidence: 99%

Wondrous Yellow Molecule: Are Hydrogels a Successful Strategy to Overcome the Limitations of Curcumin?

Stachowiak,

Mlynarczyk,

Dlugaszewska

2024

Molecules

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Curcumin is a natural compound with a great pharmaceutical potential that involves anticancer, anti-inflammatory, antioxidant, and neuroprotective activity. Unfortunately, its low bioavailability, instability, and poor water solubility significantly deteriorate its clinical use. Many attempts have been made to overcome this issue, and encapsulating curcumin in a hydrogel matrix may improve those properties. Hydrogel formulation is used in many drug delivery forms, including classic types and novel forms such as self-assembly systems or responsive to external factors. Reviewed studies confirmed better properties of hydrogel-stabilized curcumin in comparison to pure compound. The main enhanced characteristics were chemical stability, bioavailability, and water solubility, which enabled these systems to be tested for various diseases. These formulations were evaluated for wound healing properties, effectiveness in treating skin diseases, and anticancer and regenerative activity. Hydrogel formulation significantly improved biopharmaceutical properties, opening the opportunity to finally see curcumin as a clinically approved substance and unravel its therapeutic potential.

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Section: Hydrogelsmentioning

confidence: 99%