Hepatitis-Associated Antigen and Hepatocellular Carcinoma in Taiwan

Fighting against viral hepatitis: Lessons from Taiwan

“…15 Around the same time, Dr. Myron Tong collaborated with Dr. Kwang-Juei Lo of the Taipei Veterans General Hospital and detected HBsAg in 80% of HCC patients by testing 10-fold concentrated serum specimens. 16 Both studies indicated a strong association of chronic HBV infection with HCC.…”

“…7,15,16,18,19,22 Nevertheless, it would be more convincing if a prospective study could be done to show a higher risk of HCC in HBsAg carriers. Dr.…”

The ether lipid tumour marker in human liver with hepatocellular carcinoma

“…The possible connection between hepatitis infection (often with resulting cirrhosis) and HCC has been noted among groups in North America, Europe and Africa (Peters et al, 1977;Bassendine et al, 1979;Blumberg et al, 1975). Asian populations similarly affected include the Japanese (Shikata et al, 1977), Indians (Nayak et al, 1977) and Chinese in Taiwan (Tong et al, 1971). The search for the marker was therefore carried out on liver tissue with both cirrhosis and HBsAg.…”

Hepatitis-B surface antigen and antibody in Bantu patients with primary hepatocellular cancer

“…A CAUSAL relationship between chronic hepatitis-B virus (HBV) infection and primary hepatocellular cancer (PHC) is suggested by the frequency with which hepatitis-B surface antigen (HBsAg) (Sherlock et al, 1970;Prince et al, 1970;Vogel et al, 1970;Tong et al, 1971; Kew et al, 1974) and antibody against hepatitis-B core antigen (anti-HB,) (Maupas et al, 1975) are found in the serum of patients with this tumour. This association appears to be particularly strong in those areas of the world, such as the Far East and parts of Africa, where PHC occurs commonly (Prince et al, 1970;Vogel et al, 1970;Kew et al, 1974).…”

“…This association appears to be particularly strong in those areas of the world, such as the Far East and parts of Africa, where PHC occurs commonly (Prince et al, 1970;Vogel et al, 1970;Kew et al, 1974). These areas also appear to have, in the general population, both a high carrier rate of HBV (Prince, 1971;Tong et al, 1971;Hersh et al, 1971;) and a high incidence of acute virus-B hepatitis (Tong et al, 1971;Kew et al, 1974). However, in countries in which PHC is rare, e.g.…”