Fighting against viral hepatitis: Lessons from Taiwan

Chen, Ding‐Shinn

doi:10.1002/hep.24500

Cited by 60 publications

(56 citation statements)

References 92 publications

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“…Patients with chronic HBV infection have 25-40% estimated lifetime risk of developing adverse outcomes such as cirrhosis and hepatocellular carcinoma (HCC). 1,2 In the meantime, there is an annual incidence of 1-2% for hepatitis B surface antigen (HBsAg) clearance in hepatitis B e antigen (HBeAg)-negative patients, implicating a sustained immune control of HBV infection with favourable outcomes. [3][4][5] In clinical practice, two quantifiable viral factors, including HBV DNA and HBsAg levels, have been used used to evaluate viral activity.…”

Section: Hepatitis B Virus (Hbv) Infection Is a Global Healthmentioning

confidence: 99%

Higher lifetime chance of spontaneous surface antigen loss in hepatitis B carriers with genotype C infection

Tseng

Liu

Chen

et al. 2015

Aliment Pharmacol Ther

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Section: Hepatitis B Virus (Hbv) Infection Is a Global Healthmentioning

confidence: 99%

Higher lifetime chance of spontaneous surface antigen loss in hepatitis B carriers with genotype C infection

Tseng

Liu

Chen

et al. 2015

Aliment Pharmacol Ther

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“…They are the major causes of chronic hepatitis, which often leads to fibrosis progression, cirrhosis, and hepatocellular carcinoma (HCC) and, thus, poses a great threat to public health (1). Several potent antiviral agents with a minimal drug resistance profile are shown to persistently suppress HBV replication in patients with chronic hepatitis B (CHB), leading to a reduction or even a reversal of hepatic fibrosis in the treated patients (2).…”

mentioning

confidence: 99%

Sorafenib and its derivative SC-1 exhibit antifibrotic effects through signal transducer and activator of transcription 3 inhibition

Shiau²,

Jao

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

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Signal transducer and activator of transcription 3 (STAT3) had been involved in liver fibrogenesis. We aimed to explore the antifibrotic activities of sorafenib and its derivative SC-1 (devoid of Raf kinase inhibition activity) both in vivo and in vitro with special focus on the STAT3 pathway in hepatic stellate cells (HSCs). The clinical role of STAT3 in chronic hepatitis B (CHB) was also investigated. Experimental fibrosis mouse models were established by thioacetamide injection and bile duct ligation in Balb/C mice and treated with sorafenib and SC-1. Rat and human HSCs were used for mechanistic investigations. Forty CHB patients were enrolled to quantify the hepatic phospho-STAT3 (p-STAT3) levels and correlated with liver fibrosis. Both sorafenib and SC-1 ameliorated liver fibrosis in vivo and promoted HSC apoptosis in vitro. p-STAT3 and downstream signals were down-regulated after sorafenib and SC-1 treatment in HSC. STAT3 overexpression in HSC enhanced cell proliferation and undermined the apoptotic effects of sorafenib and SC-1, whereas STAT3-specific inhibition promoted HSC apoptosis. Sorafenib and SC-1 activated Src-homology protein tyrosine phosphatase-1 (SHP-1) and STAT3 inhibition followed. Of particular interest, in CHB patients with advanced liver fibrosis, p-STAT3 in HSC was significantly overexpressed and positively correlated with the severity of liver fibrosis and plasma IL-6 levels. In conclusion, sorafenib and SC-1 ameliorate liver fibrosis through STAT3 inhibition in HSC and STAT3 may potentially serve as a promising fibrotic biomarker and target in liver fibrosis. SHP-1 phosphatase-directed STAT3 inhibition may represent a previously unidentified strategy for antifibrotic drug discovery.hepatic stellate cell | STAT3 | SHP-1 | hepatitis B | liver fibrosis

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“…Chronic HBV infection is the leading cause of cirrhosis and hepatocellular carcinoma around the world (41). A study on the candidates for marriage in Iran showed a low prevalence of HBV.…”

Section: Discussionmentioning

confidence: 99%

A Qualitative Study on Marital Challenges of Chronic Hepatitis B Patients

Hassani

Ezbarami

Tafreshi

et al. 2017

Iran Red Crescent Med J

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Background: Hepatitis B is a life-threatening viral infection that is mainly transmitted through blood; due to the presence of this virus in semen, vaginal fluids, and saliva, the possibility of transmission among couples during marital life still exists. Objectives: This study was conducted to specify the patients' perception of their marital problems. Methods: In this descriptive qualitative research conducted in Iran, 32 patients with chronic hepatitis B were selected through purposive sampling. The data were collected through semi-structured interviews and field notes during 23 months in 2015 and 2016. The interview transcripts were coded by using MAXQDA10 software®. The utilization of thematic analysis approach was to extract categories and themes. Results: Participants of this study were in the chronic and inactive phase of hepatitis B. Participants' age varied from 24 to 57 years. Three major themes were extracted: premarriage challenges, conjugal life with suffering, and lack of marital adjustment. Conclusions: Like other chronic diseases, chronic hepatitis B causes numerous marital challenges for the carriers of the disease. The partners of patients with hepatitis B can be used as self-care facilitating agents in the family to promote self-care of these patients and help better manage their marital challenges.

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Fighting against viral hepatitis: Lessons from Taiwan

Cited by 60 publications

References 92 publications

Higher lifetime chance of spontaneous surface antigen loss in hepatitis B carriers with genotype C infection

Higher lifetime chance of spontaneous surface antigen loss in hepatitis B carriers with genotype C infection

Sorafenib and its derivative SC-1 exhibit antifibrotic effects through signal transducer and activator of transcription 3 inhibition

A Qualitative Study on Marital Challenges of Chronic Hepatitis B Patients

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