Hepatic vascular inflow occlusion enhances tissue destruction during cryoablation of porcine liver1

Cryoablation of liver tumours – a review of mechanisms, techniques and clinical outcome

“…We have shown that hepatic vascular inflow occlusion enables freezing of larger volumes and increases the volume of necrosis (42). The effect of vascular occlusion during ablation may be of particular importance for target tumours located close to vessels.…”

Disclosure of the significant thermal effects of large blood vessels during cryosurgery through infrared temperature mapping

“…Although experimental investigation on the thermal effect of large vessels with complex configurations such as counter-current vessel pairs and in vivo vascular network has been conducted in this study, additional experiments are still necessary on more complex cases such as considering the influences of vessel types (with different diameters and blood flow velocities) and multiple cryoprobes. Recent investigations have shown that local recurrence of tumor in an area treated with cryosurgery can occur at rates from 5% to 44% of patients [23,24]. This indicates that partial area of the tumor was not completely killed with freezing.…”

“…Besides, the availability of the technique of vascular occlusion or exclusion also provides another possible approach for such purpose. Recent studies indicated that selective vascular inflow occlusion additionally increases the volume of the lesion and may therefore be most attractive for successful clinical application [10,24]. However, the need of a major surgical procedure for vascular exclusion negates minimally invasive surgery, which is one of the major advantages of percutaneous or laporoscopic cryosurgery.…”

Gut microbiota regulates hepatic ischemia–reperfusion injury‐induced cognitive dysfunction via the HDAC2‐ACSS2 axis in mice

“…Studies have shown that occluding the hepatic portal can significantly reduce intraoperative bleeding and improve surgical visualization 4–6 . However, hepatic ischemia–reperfusion injury (HIRI), an inevitable consequence of such therapy, may have adverse effects on patient prognosis, contributing to detrimental effects such as early liver failure, tissue damage, and even liver transplant failure 7–10 …”

“…[4][5][6] However, hepatic ischemia-reperfusion injury (HIRI), an inevitable consequence of such therapy, may have adverse effects on patient prognosis, contributing to detrimental effects such as early liver failure, tissue damage, and even liver transplant failure. [7][8][9][10] Prior research has established that an imbalance in the gut microbiota is implicated in the progression of diverse conditions, including Crohn's disease, diabetes, and hypertension. [11][12][13] The gut microbiome and the connection between the gut and the brain have gained significant attention in recent years in numerous studies investigating the pathophysiology of different diseases.…”