silicon wafer, electronic skin, which is usually fabricated with mechanically compliant materials (low modulus, stretchable, and flexible) overcomes the fundamental mismatch between rigid devices and soft biological tissues. [13,14] At present, inorganic and organic electronic materials integrated with elastomeric substrates are the two popular approaches to fabricate electronic skin. Nonstretchable inorganic electronic materials, such as gold, copper, and silver, change the geometric structure to fit the stretched substrates. [15][16][17][18] It is obvious that the complicated, expensive fabrication methods, and limited stretchability of inorganic electronic materials restrict their widespread application. Alternatively, other inorganic electronic materials, such as nanoparticles [19][20][21] and carbon nanotubes, [22][23][24] are deposited on elastomer substrates to form a thin nanopath that can be extended when the substrates are stretched. With low-cost fabrication methods, such as direct printing [20,25] and transfer printing, [21] these materials have been highly successfully used to fabricate stretchable circuits, [26] sensing arrays, [27] and near field communication antennae. [21] Meanwhile, organic electronic materials, such as conductive small molecules and polymers and carbon-based conductive materials, [28] have good stretchability and their special chemical groups provide good conductivity. [29][30][31] However, the conductivities of nanoparticle layers and organic electronic materials are far lower than those of metal conductors. Thus, it is of great importance to develop new materials with both excellent conductivity and stretchability. Most electronic skin is fabricated on a flat device and subsequently transferred to skin. We suggest that the new conductive materials be directly printed onto the skin using a low-cost preparation method and be super-compliant and customizable.Liquid metal (eutectic gallium-indium, EGaIn) is an attractive conductive material that has shown significant promise for broad applications in flexible electronics. With its high electrical conductivity (EGaIn: 3.4 × 10 6 S m −1 ) [32] and excellent fluidity, [33] liquid metal has attracted great interest in many applications, such as stretchable antennae, [34,35] bioelectrodes, [36] strain sensors, [37] pressure sensors, [38] loudspeakers, [39] and soft robots. [40] Additionally, gallium is nontoxic with low vapor pressure, [41] which can be useful in an ambient environment. [42] Meanwhile, various patterning techniques of liquid metal have also been developed, such as microchannel injection, [43] atomized Because of its seamless skin interface, electronic skin has attracted increasing attention in the field of biomedical sensors and medical devices. Most electronic skins are based on organic or inorganic electronic materials. However, the low flexibility of inorganic materials and the limited conductivity of organic materials restricts their widespread use. A new approach is reported to fabricate electronic tattoos from N...

Therapeutic hyperthermia is a procedure that involves heating tissues to a higher temperature level, typically ranging from 41 degrees C to 45 degrees C. Its combination with radiotherapy and/or chemotherapy has been performed for many years, with remarkable success in treating advanced and recurrent cancers. The current hyperthermia strategies generally include local, regional, and whole-body hyperthermia, which can be implemented by many heating methods, such as microwave, radiofrequency, laser, and ultrasound. There are several hyperthermic treatment modalities in conjunction with radiotherapy/chemotherapy. Numerous studies have attempted to explain the mechanisms of thermosensitization from radiation and chemotherapy; however, a generalized standard for determining an optimal hyperthermia modality combined with radiotherapy/chemotherapy has not been established, so more research is needed. Fortunately, phase II/III clinical trials have demonstrated that hyperthermia combination therapy is beneficial for local tumor control and survival in patients with high-risk tumors of different types. The aim of this article is to present a comprehensive review of the latest advances in tumor hyperthermia combined with radiotherapy and/ or chemotherapy. We specifically focus on synergistic cellular and molecular mechanisms, thermal dose, treatment sequence, monitoring and imaging, and clinical outcomes of the combination therapy. The role of nanoparticles in sensitization during radio-/chemotherapy is also evaluated. Finally, research challenges and future trends in the related areas are presented.

Several closed form analytical solutions to the bioheat transfer problems with space or transient heating on skin surface or inside biological bodies were obtained using Green's function method. The solutions were applied to study several selected typical bioheat transfer processes, which are often encountered in cancer hyperthermia, laser surgery, thermal comfort analysis, and tissue thermal parameter estimation. Thus a straightforward way to quantitatively interpret the temperature behavior of living tissues subject to constant, sinusoidal, step, point or stochastic heatings etc. both in volume and on boundary were established. Further solution to the three-dimensional bioheat transfer problems was also given to illustrate the versatility of the present method. Implementations of this study to the practical problems were addressed.