A Review of Hyperthermia Combined With Radiotherapy/Chemotherapy on Malignant Tumors

Rao, Wei; Deng, Zhong-Shan; Liu, Jing

doi:10.1615/critrevbiomedeng.v38.i1.80

Cited by 183 publications

(130 citation statements)

References 107 publications

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“…[5][6][7] Cis-diamminedichloroplatinum (II) (cDDP, cisplatin) is a well characterized chemotherapeutic agent that has shown promising results when combined with hyperthermia, but its mechanisms of potentiation remain largely unknown. 8,9 Uptake of cDDP by the cell appears to be mediated by two distinct mechanisms, ie, active transport via copper transporter receptors and passive diffusion through the cellular membrane. 10 Currently, it is believed that active transport is the dominant mechanism of cDDP uptake.…”

Section: Introductionmentioning

confidence: 99%

Hyperthermic potentiation of cisplatin by magnetic nanoparticle heaters is correlated with an increase in cell membrane fluidity

Alvarez-Berríos¹,

Castillo²,

Mendéz³

et al. 2013

IJN

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Magnetic fluid hyperthermia as a cancer treatment method is an attractive alternative to other forms of hyperthermia. It is based on the heat released by magnetic nanoparticles subjected to an alternating magnetic field. Recent studies have shown that magnetic fluid hyperthermia-treated cells respond significantly better to chemotherapeutic treatment compared with cells treated with hot water hyperthermia under the same temperature conditions. We hypothesized that this synergistic effect is due to an additional stress on the cellular membrane, independent of the thermal heat dose effect that is induced by nanoparticles exposed to an alternating magnetic field. This would result in an increase in Cis-diammine-dichloroplatinum (II) (cDDP, cisplatin) uptake via passive transport. To test this hypothesis, we exposed cDDPtreated cells to extracellular copper in order to hinder the human cell copper transporter (hCTR1)-mediated active transport of cDDP. This, in turn, can increase the passive transport of the drug through the cell membrane. Our results did not show statistically significant differences in surviving fractions for cells treated concomitantly with magnetic fluid hyperthermia and cDDP, in the presence or absence of copper. Nonetheless, significant copper-dependent variations in cell survival were observed for samples treated with combined cDDP and hot water hyperthermia. These results correlated with platinum uptake studies, which showed that cells treated with magnetic fluid hyperthermia had higher platinum uptake than cells treated with hot water hyperthermia. Changes in membrane fluidity were tested through fluorescence anisotropy measurements using trimethylamine-diphenylhexatriene. Additional uptake studies were conducted with acridine orange and measured by flow cytometry. These studies indicated that magnetic fluid hyperthermia significantly increases cell membrane fluidity relative to hot water hyperthermia and untreated cells, and hence this could be a factor contributing to the increase of cDDP uptake in magnetic fluid hyperthermia-treated cells. Overall, our data provide convincing evidence that cell membrane permeability induced by magnetic fluid hyperthermia is significantly greater than that induced by hot water hyperthermia under similar temperature conditions, and is at least one of the mechanisms responsible for potentiation of cDDP by magnetic fluid hyperthermia in Caco-2 cells.

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Section: Introductionmentioning

confidence: 99%

Hyperthermic potentiation of cisplatin by magnetic nanoparticle heaters is correlated with an increase in cell membrane fluidity

Alvarez-Berríos¹,

Castillo²,

Mendéz³

et al. 2013

IJN

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“…10,41 However, this might be countered by increasing the SLP of the particles, reducing the frequency, application to smaller diameters such as head or extremities, and lower target temperatures. Hyperthermia has long been known to be synergistic with chemotherapy and radiotherapy 78,[92][93][94] and requires much lower temperatures (∼40°C-43°C).…”

mentioning

confidence: 99%

Intravenous magnetic nanoparticle cancer hyperthermia

Huang¹,

Hainfeld²

2013

IJN

104

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Magnetic nanoparticles heated by an alternating magnetic field could be used to treat cancers, either alone or in combination with radiotherapy or chemotherapy. However, direct intratumoral injections suffer from tumor incongruence and invasiveness, typically leaving undertreated regions, which lead to cancer regrowth. Intravenous injection more faithfully loads tumors, but, so far, it has been difficult achieving the necessary concentration in tumors before systemic toxicity occurs. Here, we describe use of a magnetic nanoparticle that, with a well-tolerated intravenous dose, achieved a tumor concentration of 1.9 mg Fe/g tumor in a subcutaneous squamous cell carcinoma mouse model, with a tumor to non-tumor ratio . 16. With an applied field of 38 kA/m at 980 kHz, tumors could be heated to 60°C in 2 minutes, durably ablating them with millimeter (mm) precision, leaving surrounding tissue intact.

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“…Its combination with radiotherapy and/or chemotherapy has been performed for many years, with remarkable success (Rao, Deng et al 2010). Synergistic effects of PDT and hyperthermia in melanoma treatment have also been demonstrated.…”

Section: Combination With Hyperthermiamentioning

confidence: 99%

Melanoma resistance to photodynamic therapy: new insights

Huang¹,

Vecchio²,

Avci

et al. 2013

Biological Chemistry

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Melanoma is the most dangerous form of skin cancer, with a steeply rising incidence and a poor prognosis in its advanced stages. Melanoma is highly resistant to traditional chemotherapy and radiotherapy, although modern targeted therapies such as BRAF inhibitors are showing some promise. Photodynamic therapy (PDT, the combination of photosensitizing dyes and visible light) has been tested for melanoma with some promising results, but melanoma is generally considered to also be resistant to PDT. Optical interference by the highly-pigmented melanin, the anti-oxidant effect of melanin, the sequestration of photosensitizers inside melanosomes, defects in apoptotic pathways, and the efflux of photosensitizers by ATP-binding cassette (ABC) transporters have all been implicated in melanoma resistance to PDT. Approaches to overcoming melanoma resistance to PDT include: the discovery of highly active photosensitizers absorbing in the 700-800-nm near infrared spectral region; interventions that can temporarily reduce the amount or the pigmentation of the melanin; compounds that can reverse apoptotic defects or inhibit drug-efflux of photosensitizers; and immunotherapy approaches that can take advantage of the ability of PDT to activate the host immune system to the treated tumor.

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A Review of Hyperthermia Combined With Radiotherapy/Chemotherapy on Malignant Tumors

Cited by 183 publications

References 107 publications

Hyperthermic potentiation of cisplatin by magnetic nanoparticle heaters is correlated with an increase in cell membrane fluidity

Hyperthermic potentiation of cisplatin by magnetic nanoparticle heaters is correlated with an increase in cell membrane fluidity

Intravenous magnetic nanoparticle cancer hyperthermia

Melanoma resistance to photodynamic therapy: new insights

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