Gut microbiota regulates hepatic ischemia–reperfusion injury‐induced cognitive dysfunction via the HDAC2‐ACSS2 axis in mice
Yanbo Liu,
Zhen Li,
Tianning Sun
et al.
Abstract:AimsHepatic ischemia–reperfusion injury (HIRI) resulting from hepatic inflow occlusion, which is a common procedure in liver surgery is inevitable. Previous research has confirmed that the cognitive dysfunction induced by HIRI is closely related to dysbiosis of the gut microbiota. This research aims to investigate the mechanisms underlying this complication.MethodsC57BL/6 mice underwent hepatic ischemia experimentally through the occlusion of the left hepatic artery and portal vein. To assess the HDAC2‐ACSS2 a… Show more
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