Hepatic involvement in lepromatous leprosy

Ferrari, Teresa C. A.; Araújo, Marcelo Grossi; Ribeiro, Maria Mônica Freitas

doi:10.47276/lr.73.1.72

Cited by 17 publications

(4 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It was either caused by the direct presence of the M. leprae or as part of an immune reaction to the pathogen. Previous studies have already shown leprosy as a cause of granulomatous hepatitis ( 21 – 25 ). Hepatosplenomegaly can also be present during a reaction episode showing a different histopathological pattern, similar to the one present on the reactionary erythema nodosum on the skin ( 25 ).…”

Section: Discussionmentioning

confidence: 98%

“…Previous studies have already shown leprosy as a cause of granulomatous hepatitis (21)(22)(23)(24)(25). Hepatosplenomegaly can also be present during a reaction episode showing a different histopathological pattern, similar to the one present on the reactionary erythema nodosum on the skin (25). The hepatic involvement in leprosy is usually with absent or mild increase on liver function tests, especially aminotransferases, but a previous case report shows the possibility of high serum aminotransferase levels from leprosyinduced liver disease (24,25).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Fever of Unknown Origin, Wasting Syndrome and Bone Marrow Involvement: A Leprosy Case Report

et al. 2022

View full text Add to dashboard Cite

Mycobacterium leprae, the etiologic agent of leprosy, is an acid-fast-staining and slow-growing bacilli that infect macrophages and Schwann cells individually or through forming globi. The clinical presentation of leprosy is broad and depends on the host immune response. We report a case of a 42-year-old Brazilian man presenting with fever of unknown origin (FUO), anemia, wasting syndrome, and neuropathy. The diagnosis of lepromatous leprosy was made after an extensive investigation revealed the presence of M. leprae in the bone marrow. Bone marrow involvement in leprosy is rare and some authors believe the presence of M. leprae in the bone marrow can act as a reservoir of the disease facilitating future relapses. It is important to investigate bone marrow involvement in leprosy, especially when the patient presents with cytopenias and positive epidemiologic history.

show abstract

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Fever of Unknown Origin, Wasting Syndrome and Bone Marrow Involvement: A Leprosy Case Report

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Elevation of hepatic enzymes besides liver histopathological changes would result in jaundice. 31,32 In this regard, accumulation of bilirubin and biliverdin in blood and consequently their urinary excretion is responsible for yellow-green color of urine. 33 Moreover, darkness of urine, due to the presence of bile products after liver damage, 34 is another fact that upholds the idea of traditional Persian medicine sages.…”

Section: Discussionmentioning

confidence: 99%

Green Urine in Traditional Persian Medicine

Kolouri

Daneshfard

Jaladat

et al. 2016

J Evid Based Complementary Altern Med

View full text Add to dashboard Cite

The color of urine is an important factor in urine examination, which can help physicians differentiate various diseases. Today, it is known that certain dyes, drug intoxications, and diseases can induce green urine discoloration. In the view of traditional Persian medicine, which is based on humoral medicine, green urine discoloration is generally referred to the dominance of coldness in the body. In fact, it is considered to be a result of a special kind of humoral imbalance and fluid depletion or retention in the human body. Persian scholars believed that green urine could be an indicator of intoxication or a predictor of an imminent spasm or convulsion in pediatric patients. Further investigations could result in finding new diagnostic scales of urine color based on the teachings of traditional Persian medicine.

show abstract

“…There are several parameters that can be used to detect liver dysfunction such as total bilirubin serum level, ALT, aspartate aminotransferase (AST), alkaline phosphatase (ALP), total protein, albumin, and globulin [1], [8], [14]. Evaluation of liver function is carried out every 4 weeks for 3 months of medication [1], [15], [16].…”

Section: Introductionmentioning

confidence: 99%

Analysis of Liver Function on Leprosy Patient with Multidrug Therapy in Haji Adam Malik General Hospital Medan from January until December 2017

Darmi¹,

Lubis²

2020

Open Access Maced J Med Sci

View full text Add to dashboard Cite

Leprosy is a chronic progressive granulomatous disease that caused by Mycobacterium leprae, an intracellular obligate bacteria. Leprosy can be treated using multidrug therapy (MDT) that can be associated with hepatotoxicity as their side effects. We included 14 patients that were all diagnosed with multibacillary leprosy, but with four drops out persons. Liver function evaluations before MDT were in the normal range. After 1st, 2nd, and 3rd months of MDT, liver function test in research subjects also in the normal range even though there is variation in this value. There is a risk of hepatotoxicity of MDT; therefore, liver function test should be done periodically for early detection of any liver dysfunction.

show abstract

Hepatic involvement in lepromatous leprosy

Cited by 17 publications

References 1 publication

Fever of Unknown Origin, Wasting Syndrome and Bone Marrow Involvement: A Leprosy Case Report

Fever of Unknown Origin, Wasting Syndrome and Bone Marrow Involvement: A Leprosy Case Report

Green Urine in Traditional Persian Medicine

Analysis of Liver Function on Leprosy Patient with Multidrug Therapy in Haji Adam Malik General Hospital Medan from January until December 2017

Contact Info

Product

Resources

About