Hepatic Disposition of Neurotoxins and Pesticides

Yang, Maria C.; McLean, Allan J.; Rivory, Laurent P.; Couteur, David G. Le

doi:10.1034/j.1600-0773.2000.pto870608.x

Cited by 29 publications

(25 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…7 It is considered among the primarily targets for malathion toxicity. 8 On the same concern kidney was one of the target organs of experimental animals attacked by acute, sub-chronic and chronic exposure to OP. 9 Besides, it has been postulated that OP produced oxidative stress in different tissues, such as kidney of rats and mice, through the formation of reactive oxygen species (ROS).…”

Section: Introductionmentioning

confidence: 99%

Ameliorative Role of Melissa officinalis against Hepatorenal Toxicities of Organophosphorus Malathion in Male Rats

El-Raheem¹

2015

MOJT

View full text Add to dashboard Cite

It has been confirmed that organophosphorus compounds OP altered glucose homeostasis. Considerable experimental and clinical evidences have contributed the beneficial effects of antioxidant compounds in plant extract on hepatorenal toxicity. The aim of this study was to evaluate whether Melissa officinalis extract, was able to ameliorative hepatorenal injury induced by organophosphorus Malathion. Malathion at 27mg/kg bw was administered to rats alone or in combination with Melissa officinalis extract at 200mg/kg bw. Malathion decreases feed intake and body weight as well as liver and kidneys weight. Moreover, Malathion increases the levels of various serum marker enzymes AST, ALT and ALP. A significant increase in the level of serum urea, uric acid and creatinine in response to ML treatment. As well as ML induced increase in MDA in liver and kidneys while induced decreases in the activities of SOD, GPx and CAT. Co-administration of malathion with Melissa officinalis extract resulted in restoration of all tested parameter. These results may be due to the significant increase recorded in acetylcholine esterase (Ach E) activity invivo after co administration of malathion and Melissa officinalis extract. In histological study of liver and kidney, Malathion induced damage in liver and kidneys. However, MO administration to ML-treated animals resulted in overall improvement in liver and kidneys damage, emphasizing its antioxidant role. In light of the available data, it can deduce that ML-induced lipid peroxidation, oxidative stress, liver and kidneys damage rats, and conjoint supplementation of MO has resulted in pronounced ameliorating effect in all tested parameter and histological picture of liver and kidney. MOJ Toxicology Research ArticleOpen Access Ameliorative role of melissa officinalis against hepatorenal toxicities of organophosphorus malathion in male rats 104Copyright: ©2015 Sief et al. Citation:Sief MM, Khalil FA, Abou-Arab AA, et al. Ameliorative role of melissa officinalis against hepatorenal toxicities of organophosphorus malathion in male rats.

show abstract

Section: Introductionmentioning

confidence: 99%

Ameliorative Role of Melissa officinalis against Hepatorenal Toxicities of Organophosphorus Malathion in Male Rats

El-Raheem¹

2015

MOJT

View full text Add to dashboard Cite

show abstract

“…Malathion has been found to exhibit rapid but asymmetrical transmembrane uptake by the liver. Therefore, the liver which is the most important organ in glucose and lipid homeostasis and production of related enzymes can be a target for malathion toxicity (Yang et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Protection of -tocopherol and selenium against acute effects of malathion on liver and kidney of rats

Al‐Othman¹

2011

Afr. J. Pharm. Pharmacol.

View full text Add to dashboard Cite

Protection from effects of the organophosphate insecticide, malathion on the liver and kidney of male Wistar albino rats by -tocopherol and selenium was investigated. Significantly greater (P<0.01) mean concentrations of malondialdehyde (MDA) and lesser concentrations (P<0.01) of reduced glutathione (GSH) and tissues total proteins were observed in liver and kidney of rats exposed to malathion. Activities of the antioxidant enzymes, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) were less in livers and kidneys of rats exposed to malathion. These effects caused by exposure to malathion were reversed when rats were subsequently treated orally with 100 mg/kg b.w. tocopherol and/or 0.1 mg selenium/kg b.w. Both tocopherol and selenium (Se) reduced the concentration of MDA, and increased concentration of total proteins and reduced glutathione and mean activities of SOD, CAT and GPx, to levels that were not significantly different from unexposed, control rats, previous to exposure to malathion. Selenium was significantly (P<0.05) more effective at recovering activities of SOD and GPx in liver and kidney of malathion treated rats than wastocopherol, whereas, -tocopherol was significantly (P<0.05) more effective at recovering activities of CAT in liver and kidney than was Se. Both -tocopherol and Se were effective in alleviating oxidative damage in liver and kidney of rats caused by malathion.

show abstract

“…The liver, which is the primary site for the biotransformation of malathion toxicity and is considered as the major active metabolizing organ which has a chief role in the detoxification process of thionoorganophosphates (Yang et al, 2000). Liver showed hepatic toxic injury beginning with fragmentation of the cytoplasm, cytosolic hydrops, diffused parenchymatous degeneration of single hepatocytes, histiocytes located between hepatic plates and the presence of fine foci of mononuclear cell infiltration.…”

Section: Discussionmentioning

confidence: 99%

The impact of the organophosphate insecticide "Malathion" on rat and the possible ameliorating role of "Thymoquinone"

Hafez¹,

El-Atrash²,

Massoud³

et al. 2017

Egypt. J. Exp. Biol. (Zoo.)

View full text Add to dashboard Cite

E za r Ha z a a H a m e d H a f e z A f a f Mo k h t a r E l -A t ra s h A h me d A b d e l -N a i m M a s s o u d M o h a m m e d Fa ra g A b d u l -A zi z A h m e d A t t i aThe impact of the organophosphate insecticide "Malathion" on rat and the possible ameliorating role of "Thymoquinone" ABSTRACT:Hepatotoxicity and nephrotoxicity are two of the most common healthy problems in the world. Extensive research was carried out to document the powerful properties of Nigella sativa (N. sativa) as an anti-tumour, bactericide, anti-cestode, antinematode, antiinflammatory, analgesic, anti -diabetic and diuretic with many other uses. Little is known about the Nigella sativa anti-toxic property in liver and kidney, thus our current study was designed to investigate the protective effects of Thymoquinone (TQ) "the main bioactive constituent of the volatile oil of Nigella sativa seeds" on the toxicity that induced by Malathion after short term (3 week) in male albino rats. Forty male adult albino rats were randomly divided into four groups (10 rats each group): 1 st group served as the control group received olive oil daily by oral stomach tube, 2 nd one is the treated group, received Malathion as a spray (570 mg/kg) in closed place for 1 hr. every day for a period of 3 weeks. 3 rd group received Malathion (with the same technique) after treated with Thymoquinone in a dose of 20 mg/kg/day orally, while the 4 t h one received Malathion (with the same technique) after treated with Thymoquinone in a dose of 40 mg/kg/day orally.Administration of Malathion significantly inc reased the concentration of liver function tests: "ALT, AST, and ALP", and Kidney function tests: "urea and creatinine". Also, it causes various histopathological changes in liver and kidney tissues. But in the groups, that treated with Thymoquinone plus Malathion: the liver function and kidney function parameters improved as a result of tissues improvement. Overall, the results of present study supported the traditional use of N. sativa and its derived products as a therapeutic agent for many diseases.

show abstract

Hepatic Disposition of Neurotoxins and Pesticides

Cited by 29 publications

References 28 publications

Ameliorative Role of Melissa officinalis against Hepatorenal Toxicities of Organophosphorus Malathion in Male Rats

Ameliorative Role of Melissa officinalis against Hepatorenal Toxicities of Organophosphorus Malathion in Male Rats

Protection of -tocopherol and selenium against acute effects of malathion on liver and kidney of rats

The impact of the organophosphate insecticide "Malathion" on rat and the possible ameliorating role of "Thymoquinone"

Contact Info

Product

Resources

About