Protection of -tocopherol and selenium against acute effects of malathion on liver and kidney of rats

Al‐Othman, Monerah R.

doi:10.5897/ajpp11.226

Cited by 52 publications

(46 citation statements)

References 74 publications

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“…All at once, the two genes utilize a powerful anti-inflammatory action preventing the NF-κB pathway. 41 On the other hand, previous studies revealed that sele nium plays important roles in the enhancement of the antioxidant defense system, 42 increased GPx activity, 43 scavenge the free radicals and ROS 44 and down regulate the NF-κB pathway, 45 Consistent with previous study, SeNPs plays important roles in the enhancement of the antioxidant defense system whereas, the administration of SeNPs caused a marked improvement in hepatic antioxidant activities, which is due to its function in the active site of many antioxidant enzymes; like GPx. 46 selenium compounds or its metabolites may directly activate the Nrf2 pathway by modifying critical thiols in Keap1.…”

mentioning

confidence: 99%

Protective Effects of omega-3 fatty acids and/ or Nano- selenium on Cisplatin and Ionizing radiation induced liver toxicity in rats

Fahmy¹,

Azim²,

Gharib³

2016

IJPER

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Cisplatin (CP) and/ or radiation exposures cause oxidative stress, which induced liver toxicity. The present study was undertaken to explore if fish oil (FO) and /or selenium nano particles (SeNPs) can minimize CP-induced hepatotoxicity and other side effects. Rats were either treated with SeNPs (0.5 mg/kg) and /or FO (2 mg/Kg) for 12 days before treatment with CP (10 mg/Kg) and/ or exposure to γ-rays (0.7Gy).The results of the present study revealed that rats treated with CP and /or γ-radiation showed an increase in the level of IL6, renin and the expression of angiotensinogen , xanthine oxidase (XO) and NF-κB protein along with a decrease in (Nrf2) protein expression as well as, the activity of antioxidant enzymes. Fish oil and /or selenium nanoparticles (SeNPs) treatment prior to CP and/ or radiation exposure normalized these parameters. Our findings suggest that FO together with SeNPs could be used as protective supplements against toxicity associated with ionizing radiation and CP due to its antioxidant, anti-inflammatory and anti-apoptotic properties.

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confidence: 99%

Protective Effects of omega-3 fatty acids and/ or Nano- selenium on Cisplatin and Ionizing radiation induced liver toxicity in rats

Fahmy¹,

Azim²,

Gharib³

2016

IJPER

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“…Significant decrease in total protein content was reported in liver and kidney tissues of malathion treated rats compared with the control group by Ozden et al (2009) andOthman (2011). Various oxidative stress parameters viz.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of oxidative stress in rats (Rattus rattus) inhabiting Bathinda region of Punjab, India

Sangha

Kalra

2015

IJAR

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Exposure to various toxic chemicals has become an increasingly recognized source of illness in human and animals, worldwide. The present study was designed to evaluate the oxidative stress in Rattus rattus inhabiting Bathinda region of Punjab. Punjab Agricultural University, Ludhiana campus rats served as control rats. Rattus rattus were brought to laboratory and separated according to sex. The animals were dissected, vital organ excised and weighed and blood and tissues were processed for histological and biochemical studies. Relative weights of liver, heart and kidney were observed to be higher in rats collected from Bathinda as compared to the control rats. Light microscopic observations of liver and kidney sections of Bathinda rats showed many histological changes. Levels of total proteins were found to be lower in blood, liver, kidney and brain of rats collected from Bathinda region. Activities of antioxidant enzymes namely catalase, glutathione peroxidase and glutathione transferase were reduced (p<0.05) and superoxide dismutase and glutathione reductase showed significant increase and the products of oxidation namely, malondialdehyde were significantly increased (p<0.05) in liver, kidney, brain and blood of rats collected from Bathinda district as compared to control rats. The results obtained indicate that environmental contaminants might be responsible for altering antioxidant defense system and inducing oxidative stress in rats inhabiting south-west region of Punjab.

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“…55 Se acts by scavenging the freeradicals and ROS. 56 This indicates that Se moderates oxidative stress-mediated complication. Moreover; Nanoparticles are designed to carry drugs and bring that medication all the way to the diseased cells in a body without harming the healthy cells.…”

Section: Discussionmentioning

confidence: 99%

Modulatory Role of Selenium Nanoparticles and Grape Seed Extract Mixture on Oxidative Stress Biomarkers in Diabetic Irradiated Rats.

Abdelaleem¹,

Hameed²,

Askar³

et al. 2016

IJPER

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Introduction: Diabetes is a metabolic disorder of several etiologies, many oral anti-hyperglycemic agents such as sulfonylurea, biguanides are obtainable, but these agents have side effects, thus there is need of a new natural anti-hyperglycemic agent. Methods: The present study was performed to evaluate the protective role of selenium nanoparticles-grape seed extract (SeNPs-GSE) mixture in ameliorating the changes in the oxidative stress biomarkers induced by gamma radiation in diabetic rats. Experimental model of diabetic irradiated rats was induced by single intrapertoneal injection of streptozotocin (STZ 45 mg/kg) followed by γ-radiation exposure (4 Gy). Forty eight rats were randomly classified into 6 experimental groups: normal, diabetic, irradiated, diabetic irradiated, diabetic treated with either SeNPs-GSE mixtureor glimepiride(1 mg) for (14) days followed by γ-radiation. Results: Results of the present study indicated that rats exposed to γ-radiation and, or STZ significantly increase serum glucose& liver MDA levels. This increase was accompanied by a decrease in the levels of serum insulin, total antioxidant (TAC), liver enzyme activities of catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD), as well as liver tissue contents of vitamin C (Vit.C) and vitamin E (Vit.E). Diabetic rats treated with (SeNPs-GSE) mixture or glimepiride before γ-radiation exert a significant improvement in all tested biochemical parameters. Conclusion:The present study showed that a mixture of (SeNPs -GSE) possesses antioxidant and anti-diabetic activities by decreasing oxidative stress biomarkers as well as blood glucose level tested in this study. The tested combination (SeNPs-GSE) mixture is more or less equally active as that of the standard tested anti-diabetic drug glimepiride

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Protection of -tocopherol and selenium against acute effects of malathion on liver and kidney of rats

Cited by 52 publications

References 74 publications

Protective Effects of omega-3 fatty acids and/ or Nano- selenium on Cisplatin and Ionizing radiation induced liver toxicity in rats

Protective Effects of omega-3 fatty acids and/ or Nano- selenium on Cisplatin and Ionizing radiation induced liver toxicity in rats

Evaluation of oxidative stress in rats (Rattus rattus) inhabiting Bathinda region of Punjab, India

Modulatory Role of Selenium Nanoparticles and Grape Seed Extract Mixture on Oxidative Stress Biomarkers in Diabetic Irradiated Rats.

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