Hepatic Concentrations of Zinc, Copper and Manganese in Infants with Extrahepatic Biliary Atresia

Concentrations of Copper and Zinc in Liver and Serum Samples in Biliary Atresia Patients at Different Stages of Traditional Surgeries

“…In general SZn concentrations were rather low, particularly in patients with severe cholestasis (Sampling Times 5 and 6), though no clear clinical symptoms with hypozincemia were observed in our patients. Our results agreed with those previously reported for BA patients (Suita 1986(Suita , 1987(Suita , 1988Cywess and Miller 1990;Endo 1991;Bayliss et al 1995).…”

“…Ohi and Lilly (1980) observed an excessive Cu accumulation in the liver at the time of the radical surgery of BA patients, and demonstrated a possibility of improving Cu excretion into bile following the surgery. Bayliss et al (1995) also reported that Cu is high in liver specimens obtained at the time of the radical surgery of BA patients, though the concentrations of zinc (Zn) and manganese are low.…”

Establishment of Dietary Reference Intakes for Dietary Antioxidants

“…The symptomatology of vitamin E deficiency in AVED is similar to that found in these latter patients (Amiel et al, 1995;Sokol et al, 1988). These observations suggest that in patients with cholestatic liver disease, there is increased oxidative stress, perhaps as a result of copper accumulation in the liver (Bayliss et al, 1995).…”

Is it necessary to re-evaluate diagnostic criteria for Wilson disease in children?

“…Moreover, liver copper may increase above 250 µg/g, a conventional cut-off value, in other chronic liver diseases with bile stasis. Göksu et al (15) reported high copper concentrations in liver samples obtained from infants with biliary atresia at autopsy and Bayliss et al (16) reported high copper levels in liver specimens obtained from biliary atresia patients at the time of radical surgery. Elevated hepatic copper levels are seen in cholestatic liver diseases such as primary biliary cirrhosis, extrahepatic biliary obstruction, cryptogenic cirrhosis, and hepatitis in studies on humans and animals (17)(18)(19)(20)(21)(22)(23).…”