Concentrations of Copper and Zinc in Liver and Serum Samples in Biliary Atresia Patients at Different Stages of Traditional Surgeries

Sato, Chie; Koyama, Hiroshi; Satoh, Hiroshi; Hayashi, Yutaka; Chiba, Tsuneo; Ohi, Ryoji

doi:10.1620/tjem.207.271

Cited by 25 publications

(17 citation statements)

References 14 publications

(19 reference statements)

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“…However, plasma zinc concentrations do not seem to reflect the concentration found in the liver parenchyma (Göksu & Özsoylu, 1986;Sato et al, 2005). This may be explained by the fact that there are very efficient homeostatic mechanisms to correct plasma or serum zinc deficiencies, which makes it difficult to diagnose marginal deficiency by using this method.…”

Section: Discussionmentioning

confidence: 97%

“…It also inhibits transition metals, such as copper and iron, from producing reactive types of oxygen (Powell, 2000). This metal is also essential for DNA and RNA polymerase, which has an important effect in hepatic regeneration (Sato et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

“…In patients with alcoholic cirrhosis, studies found abnormal zinc concentrations not only in the liver parenchyma (Rodriguez-Moreno et al, 1997), but also in subcellular fractions of the liver (Bode et al, 1988). In other diseases, such as biliary atresia (Bayliss et al, 1995;Sato et al, 2005), Indian childhood cirrhosis (Bhardwaj et al, 1980;Sharda & Bhandari, 1986), and chronic hepatitis B (Gür et al, 1998), also were found low liver zinc concentrations.…”

Section: Introductionmentioning

confidence: 98%

See 2 more Smart Citations

An Assay for Determination of Hepatic Zinc by AAS - Comparison of Fresh and Deparaffinized Tissue

Pinto¹,

Fröehlich²,

Schneider³

et al. 2012

Macro to Nano Spectroscopy

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

An Assay for Determination of Hepatic Zinc by AAS - Comparison of Fresh and Deparaffinized Tissue

Pinto¹,

Fröehlich²,

Schneider³

et al. 2012

Macro to Nano Spectroscopy

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“…Göksu et al (15) reported high copper concentrations in liver samples obtained from infants with biliary atresia at autopsy and Bayliss et al (16) reported high copper levels in liver specimens obtained from biliary atresia patients at the time of radical surgery. Elevated hepatic copper levels are seen in cholestatic liver diseases such as primary biliary cirrhosis, extrahepatic biliary obstruction, cryptogenic cirrhosis, and hepatitis in studies on humans and animals (17)(18)(19)(20)(21)(22)(23). In our study, mean liver copper levels were higher in WD patients than in patients with non-WD liver diseases.…”

Section: Discussionmentioning

confidence: 99%

Is it necessary to re-evaluate diagnostic criteria for Wilson disease in children?

Sezer¹,

Perk²,

Hoşnut³

et al. 2015

Turk J Gastroenterol

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“…Hambidge et al 22 , estudando crianças com atresia biliar, não encontraram diferenças significativas entre zinco plasmático, função hepática e drenagem biliar. Sato et al 23 avaliaram os níveis de cobre e zinco em crianças com atresia biliar em diferentes estágios e encontraram uma redução nas concentrações de zinco hepático e sérico e um aumento das concentrações de cobre à medida que a doença evoluía. Em nosso estudo, o nível médio de zinco plasmático em todos os pacientes do grupo com cirrose ficou dentro dos valores normais; contudo, quando os pacientes foram separados em grupos de acordo com os critérios Child-Pugh, os pacientes classificados como A tiveram concentrações médias dentro dos valores normais, mas os pacientes B e C tiveram médias abaixo do ponto de corte.…”

Section: Discussionunclassified

Low plasma zinc concentrations in pediatric patients with cirrhosis

Schneider¹,

Pinto²,

Fröehlich³

et al. 2009

J Pediatr (Rio J)

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Objective: To determine plasma zinc concentrations in children and adolescents with cirrhosis and to investigate the association between these results and dietary zinc intake, anthropometric data, and severity of liver disease.Methods: Plasma zinc concentration was assessed by atomic absorption spectrophotometry in 30 children and adolescents with cirrhosis (105.0±60.0 months; 22 girls) and 27 without liver disease (122.3±47.3 months, 14 girls). Dietary zinc data were evaluated by 3-day food intake records. Anthropometry measures included height, weight, skinfold thickness, brachial circumference, and upper arm muscle size. Severity of liver disease was classified according to the Child-Pugh, MELD, and PELD criteria. Results:The mean (± standard deviation) plasma zinc concentrations in control subjects and patients were 105.69±19.46 and 75.44±24.45 µg/dL, respectively (p < 0.001). No associations were found between anthropometric measures, dietary zinc intake, and plasma zinc concentration. There was statistical difference related to plasma zinc concentrations between Child-Pugh B + C patients and control subjects (p < 0.001), and concerning PELD, between patients below the cutoff score of 15 and those above (p = 0.002). Conclusions:The prevalence of hypozincemia was 43% for patients with cirrhosis. Although low plasma zinc concentration was associated with more severe liver disease, it was present even in some Child-Pugh A patients. Therefore, zinc supplementation should be considered for cirrhotic children.J Pediatr (Rio J). 2009;85(4):359-364: Zinc, liver cirrhosis, anthropometry, child. ResumoObjetivo: Determinar a concentração plasmática de zinco em crianças e adolescentes cirróticos e investigar a associação entre esses resultados e a ingestão dietética de zinco, os dados antropométricos e a gravidade da doença hepática.Métodos: As concentrações plasmáticas de zinco foram avaliadas por espectrofotometria de absorção atômica em 30 crianças e adolescentes com cirrose (105,0±60,0 meses; 22 meninas) e 27 hígidas e sem doença hepática (122,3±47,3 meses, 14 meninas). Os dados relacionados ao zinco dietético foram avaliados por registro de ingestão alimentar de 3 dias. A antropometria incluiu peso, altura, espessura da dobra cutânea, circunferência braquial e área muscular do braço. A gravidade da doença hepática foi classificada de acordo com os critérios de Child-Pugh, MELD e PELD. Resultados: As concentrações plasmáticas de zinco dos indivíduos controles e dos pacientes foram 105,69±19,46 e 75,44±24,45 µg/dL, respectivamente (p < 0,001). Nenhuma associação foi encontrada entre os índices antropométricos, a ingestão dietética e o zinco plasmático. Houve diferença estatística nas concentrações de zinco plasmático entre pacientes Child-Pugh B+C e controles (p < 0,001), e com relação ao PELD, entre pacientes abaixo e acima do ponto de corte 15 (p = 0,002). Conclusão:A prevalência de hipozincemia foi de 43% para pacientes com cirrose. A baixa concentração plasmática de zinco foi associada com a doença hepát...

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Concentrations of Copper and Zinc in Liver and Serum Samples in Biliary Atresia Patients at Different Stages of Traditional Surgeries

Cited by 25 publications

References 14 publications

An Assay for Determination of Hepatic Zinc by AAS - Comparison of Fresh and Deparaffinized Tissue

An Assay for Determination of Hepatic Zinc by AAS - Comparison of Fresh and Deparaffinized Tissue

Is it necessary to re-evaluate diagnostic criteria for Wilson disease in children?

Low plasma zinc concentrations in pediatric patients with cirrhosis

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