Hepatic artery thrombosis and liver malignancy in pediatric liver transplantation

Sanchez, Sabrina E.; Javid, Patrick J.; Lao, Oliver B.; Dick, A.; Perkins, James D.; Reyes, Jorgé; Horslen, Simon; Healey, Patrick J.; Sawin, Robert S.

doi:10.1016/j.jpedsurg.2012.03.035

Cited by 20 publications

(17 citation statements)

References 19 publications

(30 reference statements)

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“…These patients are at higher risk for thrombosis because of technical challenges associated with anastomoses of smaller vessels, use of segmental grafts, and the increased risk for thrombosis associated with hepatic malignant neoplasms. 23 This finding is similar to that of a previous series with incidence of hepatic artery thrombosis as high as 28%.…”

Section: Discussionsupporting

confidence: 92%

Effect of Liver Transplant on Long-term Disease-Free Survival in Children With Hepatoblastoma and Hepatocellular Cancer

et al. 2015

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Section: Discussionsupporting

confidence: 92%

Effect of Liver Transplant on Long-term Disease-Free Survival in Children With Hepatoblastoma and Hepatocellular Cancer

et al. 2015

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“…2–6,8–13,30 The incidence of bleeding in our cohort was also higher than what has been reported previously (20.7% vs. 5–15%), 11–13,30 but bleeding is reported inconsistently in prior cohorts and definitions vary, making the comparison difficult. Despite bleeding and thrombosis being similarly frequent events in our cohort, only thrombotic complications were associated with patient mortality.…”

Section: Discussioncontrasting

confidence: 75%

Bleeding and thrombotic complications of pediatric liver transplant

Borst

Sudan

Wang

et al. 2018

Pediatric Blood & Cancer

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“…One study found a lower incidence of late HAT in an ASA prophylaxis group versus patients who did not receive prophylaxis (0.4% versus 2.2%), and another study found similar frequencies of late HAT in patients using ASA and patients not using ASA (1.2% versus 1.0%). HAT studies of pediatric patients have found no significant differences in early HAT incidence between patients using ASA and patients not using ASA or in the frequency of ASA or alprostadil usage between patients with HAT and patients without HAT . The benefits and risks of ASA in reducing HAT after LT have not been studied to our knowledge in randomized controlled trials.…”

Section: Discussionmentioning

confidence: 97%

“…HAT studies of pediatric patients have found no significant differences in early HAT incidence between patients using ASA and patients not using ASA or in the frequency of ASA or alprostadil usage between patients with HAT and patients without HAT. 21,22 The benefits and risks of ASA in reducing HAT after LT have not been studied to our knowledge in randomized controlled trials. Therefore, one might argue that its use should not be recommended, but recommendations are frequently based on observational studies, at least in distinguished general medicine journals.…”

Section: Discussionmentioning

confidence: 99%

Late hepatic artery thrombosis after pediatric liver transplantation: A cross-sectional study of 34 patients

et al. 2014

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Hepatic artery thrombosis (HAT) after liver transplantation (LT) increases patient morbidity and mortality. Early HAT is considered to occur within the first month after LT, whereas late HAT occurs after the first month. Few studies have addressed late HAT after LT, especially in pediatric patients. Between 1987 and 2007, 99 patients (age < 18 years) underwent deceased donor LT. Thirty-four of 66 eligible patients (52%) underwent magnetic resonance imaging (MRI) according to protocol. On the basis of MRI findings, the patients were grouped as those who experienced late HAT and those who did not. Additionally, potential risk factors for late HAT were analyzed retrospectively. P values were adjusted for multiplicity. The median age at LT was 1.7 years [interquartile range (IQR) 5 1.0-9.6 years], and the median follow-up time at MRI was 9.5 years (IQR 5 4.0-16.4 years). Late HAT was diagnosed in 15 of the 34 patients [44%, 95% confidence interval (CI) 5 29%-61%] undergoing MRI and in 3 of these patients with angiography preceding MRI. Ultrasonography revealed late HAT in 6 of these 15 patients with a sensitivity of 40% (95% CI 5 20%-64%). The donor/recipient weight ratio remained significantly higher for the patients with late HAT versus the patients without late HAT after P values were adjusted (5.4 versus 1.9, P 5 0.03). No marked differences were observed in laboratory or liver histology parameters between the groups. In conclusion, late HAT is common after pediatric LT. The donor/recipient weight ratio was higher for patients with late HAT, and this was attributable to the lower weight of the recipients. No salient features of late HAT were observed with respect to laboratory or histological parameters, at least in terms of our study's cross-sectional period. Liver Transpl 20:591-600, 2014. V C 2014 AASLD.Received October 22, 2013; accepted January 30, 2014. See Editorial on Page 512Vascular complications after liver transplantation (LT) decrease both graft and patient survival.1 Hepatic artery thrombosis (HAT) is a major cause of retransplantation in the pediatric population.2 Early and late forms of HAT have been described, but the exact time interval for these 2 forms has not been established. However, most studies define early HAT as occurring within the first month after LT. 3The incidence of early HAT is higher in pediatric patients versus adult patients, and risk factors for early HAT have been proposed even in a contradictory manner.3 For example, in the setting of pediatric LT,

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Hepatic artery thrombosis and liver malignancy in pediatric liver transplantation

Cited by 20 publications

References 19 publications

Effect of Liver Transplant on Long-term Disease-Free Survival in Children With Hepatoblastoma and Hepatocellular Cancer

Effect of Liver Transplant on Long-term Disease-Free Survival in Children With Hepatoblastoma and Hepatocellular Cancer

Bleeding and thrombotic complications of pediatric liver transplant

Late hepatic artery thrombosis after pediatric liver transplantation: A cross-sectional study of 34 patients

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