Hepatic and renal metallothionein induction by an oral equimolar dose of zinc, cadmium or mercury in mice

Tandon, S. K.; Singh, Surendra; Prasad, Somuri V.; Mathur, Neeraj

doi:10.1016/s0278-6915(00)00167-8

Cited by 48 publications

(31 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It suggests that oxidation takes place immediately after exposure and before defence mechanisms kick in (34). This correlation also confirms the potent prooxidant properties of Cd, even at low environmental concentrations.…”

Section: Correlations Between Blood and Liver Metals And Liver Paramesupporting

confidence: 63%

“…To some extent this phenomenon can be explained by the fact that long exposure to metals and their accumulation in the liver trigger effective defence mechanisms, which inhibit oxidative processes such as the synthesis of metallothionein (MT) and increase tissue production and accumulation of glutathione (34).…”

Section: Correlations Between Blood and Liver Metals And Liver Paramementioning

confidence: 99%

See 1 more Smart Citation

Effects of chronic exposure to lead, cadmium, and manganese mixtures on oxidative stress in rat liver and heart / Utjecaj kronične istodobne izloženosti olovu, kadmiju i manganu na oksidativni stres u jetri i srcu štakora

Markiewicz−Górka

Januszewska

Michalak

et al. 2015

Archives of Industrial Hygiene and Toxicology

View full text Add to dashboard Cite

The aim of this study was to assess the effects of chronic combined exposure to low, environmental doses of Cd, Pb, and Mn on oxidative stress in the liver and heart of rats and on their liver function parameters. Male Wistar rats were divided randomly into eight groups. For nine months controls were receiving drinking water alone, whereas the exposed groups were receiving drinking water with Pb (0.2 mg L -1 ), Cd (1 mg L -1 ), and Mn (2 mg L -1 ) alone or in combinations. Malondialdehyde (MDA) significantly increased in both heart and liver of the animals after combined exposure to metals. Heart MDA correlated with blood Cd, Pb, and Mn and liver MDA with blood Cd. Aspartate aminotransferase (AST) activity and bilirubin concentration also increased significantly in the animal group exposed to all three metals and correlated positively with blood Cd, Pb, and Mn. Our study has confirmed the synergistic effect of the Cd, Mn, and Pb combination on the increase in heart MDA. A similar synergy was observed for Pb+Mn in the increase of serum alanine aminotransferase (ALT) activity as an indicator of liver function.

show abstract

Section: Correlations Between Blood and Liver Metals And Liver Paramesupporting

confidence: 63%

Section: Correlations Between Blood and Liver Metals And Liver Paramementioning

confidence: 99%

Effects of chronic exposure to lead, cadmium, and manganese mixtures on oxidative stress in rat liver and heart / Utjecaj kronične istodobne izloženosti olovu, kadmiju i manganu na oksidativni stres u jetri i srcu štakora

Markiewicz−Górka

Januszewska

Michalak

et al. 2015

Archives of Industrial Hygiene and Toxicology

View full text Add to dashboard Cite

show abstract

“…Thus, MTs play a protective role against the toxicity of non-essential metals. 18,19 In the present experiment, the quantity of Cd/Hg binding metallothionein fractions increases with the duration of exposure (Fig. 4).…”

Section: Main Group Metal Compoundssupporting

confidence: 58%

Bioaccumulation of metals and induction of metallo‐ thioneins in selected tissues of common carp (Cyprinus carpio L.) co‐exposed to cadmium, mercury and lead

Huang

Zhang

Chen

et al. 2006

Applied Organom Chemis

View full text Add to dashboard Cite

The concentrations of mercury (Hg), cadmium (Cd) and lead (Pb) at various exposure periods were determined in the gill, kidney, liver and muscle of common carp (Cyprinus carpio L.) co-exposed to 1.0 µg ml −1 each of Cd 2+ , Hg 2+ and Pb 2+ for up to 10 days. Metallothionein fractions (MTs) in these organs were characterized using the hyphenated technique of size-exclusion chromatography (SEC) and inductively coupled plasma mass spectrometry (ICP-MS). After 10 days of exposure, maximum toxic metal concentrations of Hg, Cd and Pb were 10.7 (gill), 0.145 (kidney) and 0.112 µg g −1 dry weight (gill), respectively. The pattern of accumulation of Hg and Pb was in the order gill > kidney > liver > muscle. In the case of Cd, accumulation was in the order kidney > gill > liver > muscle. Cd and Hg binding MTs were significantly induced in the gill, kidney and liver of all the exposure groups in comparison with the control group (p < 0.05), and the amounts of them increased with the longer exposure time. Despite the higher intracellular Hg concentration and the stronger Hg-SH binding affinity, the amount of Cd-binding MTs was much higher than that of Hg-binding MTs. The results indicate that MT synthesis in these organs was clearly metal-specific. MTs in gill may be used as a bio-marker to detect the metal pollution caused by Hg and Cd. Zinc and copper binding MTs in the organs of the exposed fish were also increased. This may be due to the MTs' important role in the homeostatic regulation of essential metals and their protective role against the acute toxicity of non-essential metals. Even though there was considerable accumulation of lead in the organs of the exposed fish, Pb-binding MT synthesis was non-significant.

show abstract

“…The administration of Cd and lead (Pb) may induce changes in the metabolism of essential metals like Zn, iron (Fe) and Cu, altering the activity of metal-dependent enzymes [12].…”

Section: Introductionmentioning

confidence: 99%

Influence of cadmium and copper on tissue element levels of pregnant rats

et al. 2007

View full text Add to dashboard Cite

AbstractIn the current study, we examined the effects of Cd on Cd, Cu, Zn and Fe levels in placenta and maternal and fetal plasma and tissues, the placental weight, total fetal and maternal body weights, and fetal and maternal tissue weights during pregnancy. A total of 21 adult female rats were treated during gestation with drinking water containing one of the following: 70 mg/L of CdCl2, a combination of 70 mg/L of CdCl2 and 70 mg/L of CuSO4, or no addition (control). Placenta Cu and Fe levels, fetal liver and kidney Cu levels, and fetal liver tissue weights were lower in the group administered Cd than in the control group. Also, Cd levels in the placenta, maternal and fetal liver, and maternal kidney were higher in the group treated with Cd than in controls. In the group administered both Cd and Cu, fetal body and tissue weights did not change, but Cd levels in the placenta, maternal and fetal liver, and maternal kidneys were higher than in controls. Zn and Fe levels in the maternal kidney and fetal liver were also lower in this group. Cd exposure during pregnancy resulted in Cd accumulation in maternal and fetal tissues during pregnancy and a decrease in the total weight of fetuses, and the combination of Cd and Cu caused some changes in the both maternal and fetal levels of Cu, Zn, and Fe, but it did not cause changes in the total fetal body weight or the weights of individual tissues.

show abstract

Hepatic and renal metallothionein induction by an oral equimolar dose of zinc, cadmium or mercury in mice

Cited by 48 publications

References 22 publications

Effects of chronic exposure to lead, cadmium, and manganese mixtures on oxidative stress in rat liver and heart / Utjecaj kronične istodobne izloženosti olovu, kadmiju i manganu na oksidativni stres u jetri i srcu štakora

Effects of chronic exposure to lead, cadmium, and manganese mixtures on oxidative stress in rat liver and heart / Utjecaj kronične istodobne izloženosti olovu, kadmiju i manganu na oksidativni stres u jetri i srcu štakora

Bioaccumulation of metals and induction of metallo‐ thioneins in selected tissues of common carp (Cyprinus carpio L.) co‐exposed to cadmium, mercury and lead

Influence of cadmium and copper on tissue element levels of pregnant rats

Contact Info

Product

Resources

About