Henoch Schonlein Purpura as Possible Sole Manifestation of Covid-19 in Children

Falou, Sarah; Kahil, Ghina; Merhi, Bassem Abou; Dana, Rouwayda; Chokr, Imad

doi:10.31080/aspe.2021.04.0377

Cited by 7 publications

(9 citation statements)

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“…One article, even though initially considered due to a similar clinical picture to IgAV, was eventually removed as it ruled out IgAV and concluded with a different diagnosis after histological investigations. Finally, 16 articles were selected for inclusion: 13 articles, 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 including 9 case reports 16 , 17 , 18 , 19 , 20 , 21 , 22 , 26 , 27 and 4 letters to the editor, 15 , 23 , 24 , 25 reported cases of IgAN and IgAV following COVID-19 infection. The data of these 13 cases are summarized in the form of two tables ( Table 1 , Table 2 ), one focusing on notable clinical findings and outcomes, the other on major laboratory investigations.…”

Section: Resultsmentioning

confidence: 99%

“… 26 , 2020 Peru 4, F – Past, resolved 5 days after COVID-19 Dry cough, rhinorrhea, fever – Maculopapular lesions, painful feet, hematemesis, abdominal pain, purpura Steroids, metamizole, piperazine, antibiotics, ivermectin, omeprazole Progressive decrease in abdominal pain & purpuric lesions, discharged – 13 Sarah Falou et al. 27 , 2021 Lebanon 8, M – Ongoing, asymptomatic 3 days after COVID-19 – – Purpura, ankle pain IV hydration, NSAIDs, paracetamol Discharged on 5th day, rash & ankle pain resolved – Abbreviations: M Male, F Female, GFR Glomerular Filtration Rate, Cr Creatinine, HSP Henoch Schonlein Purpura, HTN hypertension, RFTs Renal Function Tests, LFTs Liver Function Tests, UACR Urine Albumin to Creatinine Ratio, IV Intravenous, LMWH Low Molecular Weight Heparin, NSAIDs Nonsteroidal Anti-inflammatory Drugs, CPAP Continuous Positive Airway Pressure (−) data not reported. …”

Section: Resultsmentioning

confidence: 99%

“… 26 , 2020 IgM/IgG Antibody Thrombocytosis, aPTT prolonged, Hb, total proteins & albumin decreased Urea normal Cr low – – – – – – US: thickened cecum wall with an inflammatory appearance 13 Sarah Falou et al. 27 , 2021 RT-PCR CRP normal platelets normal Cr normal Normal – – – – – – Abbreviations: RT-PCR Reverse Transcriptase-Polymerase Chain Reaction, CRP C-Reactive Protein, ESR Erythrocyte Sedimentation Rate, Hb Hemoglobin, Hct Hematocrit, Cr Creatinine, RBCs Red Blood Cells, IgAN IgA Nephropathy, US Ultrasound, EGD Esophagogastroduodenoscopy, aPTT Activated Partial Thromboplastin Time, (−) data not reported. …”

Section: Resultsmentioning

confidence: 99%

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The pathogenesis of COVID-19-induced IgA nephropathy and IgA vasculitis: A systematic review

Farooq

Rehman

Asmar

et al. 2022

Journal of Taibah University Medical Sciences

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Objective IgA nephropathy (IgAN) and IgA vasculitis (IgAV) are part of a similar clinical spectrum. Both clinical conditions occur with the coronavirus disease 2019 (COVID-19). This review aims to recognize the novel association of IgAN and IgAV with COVID-19 and describe its underlying pathogenesis. Methods We conducted a systematic literature search and data extraction from PubMed, Cochrane, ScienceDirect, and Google Scholar following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Results Our search identified 13 cases reporting IgAV and IgAN associated with COVID-19 infection and 4 cases of IgAN following COVID-19 vaccination. The mean, mode, and median ages of patients were 23.8, 4, and 8 years, respectively. Most cases associated with COVID-19 infection were reported in males (76.9%). Rash and purpura (84.6%) were the most common clinical features, followed by gastrointestinal symptoms (61.5%). In symptomatic cases, skin or renal biopsy and immunofluorescence confirmed the diagnosis of IgAN or IgAV. Most patients were treated with steroids and reported recovery or improvement; however, death was reported in two patients. Conclusion There is a paucity of scientific evidence on the pathogenesis of the association of IgAN and IgAV vasculitis with COVID-19, which thus needs further study. Current research suggests the role of IgA-mediated immune response, evidenced by early seroconversion to IgA in COVID-19 patients and the role of IgA in immune hyperactivation as the predominant mediator of the disease process. Clinicians, especially nephrologists and paediatricians, need to recognize this association, as this disease is usually self-limited and can lead to complete recovery if prompt diagnosis and treatment are provided.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

The pathogenesis of COVID-19-induced IgA nephropathy and IgA vasculitis: A systematic review

Farooq

Rehman

Asmar

et al. 2022

Journal of Taibah University Medical Sciences

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“…Concerning IgA vasculitis related to COVID-19, 15 cases (12 men; 3 women) in 13 reports have been published to date [24][25][26][27][28][29][30][31][32][33][34][35][36], which are summarized in Table 2. Half of the cases were diagnosed in childhood.…”

Section: Resultsmentioning

confidence: 99%

Vasculitis flare after COVID-19: report of two cases in patients with preexistent controlled IgA vasculitis and review of the literature

et al. 2022

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has been related to several autoimmune diseases, triggering the appearance of autoantibodies and endothelial dysfunction. Current evidence has drawn attention to vasculitis-like phenomena and leukocytoclastic vasculitis in some COVID-19 patients. Moreover, it has been hypothesized that COVID-19 could induce flares of preexisting autoimmune disorders. Here, we present two patients with previously controlled IgA vasculitis who developed a renal and cutaneous flare of vasculitis after mild COVID-19, one of them with new-onset ANCA vasculitis. These patients were treated with glucocorticoids and immunosuppressants achieving successful response. We also provide a focused literature review and conclude that COVID-19 may be associated with triggering of vasculitis and could induce flares of previous autoimmune diseases.

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“…In the second selection round, full-text articles of the remaining papers were assessed. For the final analysis, we retained 67 reports [ [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] , [46] , [47] , [48] , [49] , [50] , [51] , [52] , [53] , [54] , [55] , [56] , [57] , [58] , [59] , [60] , [61] , [62] , [63] , [64] , [65] , [66] , [67] , [68] , [69] , [70] , <...…”

Section: Resultsmentioning

confidence: 99%

Coronavirus disease 2019, vaccination against coronavirus and immunoglobulin A-mediated diseases: systematic literature review

Bronz¹,

Faré²,

Lava³

et al. 2022

Journal of Autoimmunity

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Henoch Schonlein Purpura as Possible Sole Manifestation of Covid-19 in Children

Cited by 7 publications

References 0 publications

The pathogenesis of COVID-19-induced IgA nephropathy and IgA vasculitis: A systematic review

The pathogenesis of COVID-19-induced IgA nephropathy and IgA vasculitis: A systematic review

Vasculitis flare after COVID-19: report of two cases in patients with preexistent controlled IgA vasculitis and review of the literature

Coronavirus disease 2019, vaccination against coronavirus and immunoglobulin A-mediated diseases: systematic literature review

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