Coronavirus disease 2019, vaccination against coronavirus and immunoglobulin A-mediated diseases: systematic literature review

Bronz, Gabriel; Faré, Pietro B.; Lava, Sebastiano A. G.; Bianchetti, Mario G.; Simonetti, Giacomo D.; Scoglio, Martin; Beretta‐Piccoli, Benedetta Terziroli; Agostoni, Carlo; Milani, Gregorio P.

doi:10.1016/j.jaut.2022.102899

Cited by 7 publications

(6 citation statements)

References 79 publications

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“…IGA Glomerulonephritis is a kind of immunoglobulin A related inflammation and usually occurs following viral infection. Increasing evidence supports that COVID-19 infection and vaccination against SARS-CoV-2 may trigger or exacerbate IGA Glomerulonephritis ( Bronz et al, 2022 ). Another strongly correlated immune disease identified in the network is Lupus Erythematosus, Systemic.…”

Section: Discussionmentioning

confidence: 99%

Bioinformatics and system biology approach to identify the influences of SARS-CoV-2 on metabolic unhealthy obese patients

Huang,

Jiang,

Song

et al. 2023

Front. Mol. Biosci.

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Introduction: The severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) has posed a significant challenge to individuals’ health. Increasing evidence shows that patients with metabolic unhealthy obesity (MUO) and COVID-19 have severer complications and higher mortality rate. However, the molecular mechanisms underlying the association between MUO and COVID-19 are poorly understood.Methods: We sought to reveal the relationship between MUO and COVID-19 using bioinformatics and systems biology analysis approaches. Here, two datasets (GSE196822 and GSE152991) were employed to extract differentially expressed genes (DEGs) to identify common hub genes, shared pathways, transcriptional regulatory networks, gene-disease relationship and candidate drugs.Results: Based on the identified 65 common DEGs, the complement-related pathways and neutrophil degranulation-related functions are found to be mainly affected. The hub genes, which included SPI1, CD163, C1QB, SIGLEC1, C1QA, ITGAM, CD14, FCGR1A, VSIG4 and C1QC, were identified. From the interaction network analysis, 65 transcription factors (TFs) were found to be the regulatory signals. Some infections, inflammation and liver diseases were found to be most coordinated with the hub genes. Importantly, Paricalcitol, 3,3′,4,4′,5-Pentachlorobiphenyl, PD 98059, Medroxyprogesterone acetate, Dexamethasone and Tretinoin HL60 UP have shown possibility as therapeutic agents against COVID-19 and MUO.Conclusion: This study provides new clues and references to treat both COVID-19 and MUO.

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Section: Discussionmentioning

confidence: 99%

Bioinformatics and system biology approach to identify the influences of SARS-CoV-2 on metabolic unhealthy obese patients

Huang,

Jiang,

Song

et al. 2023

Front. Mol. Biosci.

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“…With the spread of SARS‐CoV‐2, several case reports or series on COVID‐19‐related IgAV have been published. Among all COVID‐19‐related vasculitis, IgAV is one of the most commonly reported systemic vasculitis induced by SARS‐CoV‐2 infection or vaccination 65,67 . Several systematic reviews on COVID‐19‐related IgAV demonstrated that IgAV triggered by SARS‐CoV‐2 affected adult patients predominantly and tended to have a better prognosis than that of de novo systemic vasculitis, with a favorable response to glucocorticoids with or without immunosuppression 65,67 .…”

Section: Update Of Association Between Igav and Covid‐19mentioning

confidence: 99%

“…Among all COVID‐19‐related vasculitis, IgAV is one of the most commonly reported systemic vasculitis induced by SARS‐CoV‐2 infection or vaccination 65,67 . Several systematic reviews on COVID‐19‐related IgAV demonstrated that IgAV triggered by SARS‐CoV‐2 affected adult patients predominantly and tended to have a better prognosis than that of de novo systemic vasculitis, with a favorable response to glucocorticoids with or without immunosuppression 65,67 . However, the disease course in children with COVID‐19‐related IgAV is not usually benign or self‐limiting 7 .…”

Section: Update Of Association Between Igav and Covid‐19mentioning

confidence: 99%

Immunoglobulin A vasculitis: The clinical features and pathophysiology

Hu,

Yang,

Chiang

2024

The Kaohsiung J of Med Scie

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Palpable purpura, gastrointestinal symptoms, joint involvement, and renal disease characterize immunoglobulin A vasculitis (IgAV). Renal involvement ranging from mild proteinuria to severe nephritic or nephrotic syndrome highlights the importance of monitoring kidney function in patients with IgAV. Recognizing these key features is crucial for early diagnosis and appropriate management to prevent long‐term complications related to kidney disease. However, the pathogenesis of IgAV remains unclear. Disease mechanisms involve various factors, including the interplay of aberrantly glycosylated IgA, anti‐endothelial cell antibodies, and neutrophils following infection triggers, which are the main pathogenic mechanisms of IgAV. Insights from cases of IgAV related to Coronavirus disease 2019 have offered additional understanding of the connection between infection and IgAV pathogenesis. This review provides a valuable resource for healthcare professionals and rheumatology researchers seeking a better understanding of the clinical features and pathophysiology of IgAV.

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“…The connection between COVID-19 vaccination and IgAN has also been explored; in some cases, after the COVID-19 vaccine, patients already affected by IgAN showed recurrence of significant hematuria and proteinuria. Some patients had gross hematuria after the first dose of the vaccine, accompanied by increased proteinuria, arthralgia, and abdominal pain [ 128 , 129 ]. These data indicate that the connection between anti-COVID vaccination and IgAN should be investigated and that it is necessary to monitor those who show symptoms of IgA disease after the vaccine or to check those who are already affected by the disease and need to undergo vaccination.…”

Section: Iga Nephropathy and Virusesmentioning

confidence: 99%

The Human Virome and Its Crosslink with Glomerulonephritis and IgA Nephropathy

Sallustio

Picerno

Montenegro

et al. 2023

IJMS

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The prokaryotic, viral, fungal, and parasitic microbiome exists in a highly intricate connection with the human host. In addition to eukaryotic viruses, due to the existence of various host bacteria, phages are widely spread throughout the human body. However, it is now evident that some viral community states, as opposed to others, are indicative of health and might be linked to undesirable outcomes for the human host. Members of the virome may collaborate with the human host to retain mutualistic functions in preserving human health. Evolutionary theories contend that a particular microbe’s ubiquitous existence may signify a successful partnership with the host. In this Review, we present a survey of the field’s work on the human virome and highlight the role of viruses in health and disease and the relationship of the virobiota with immune system control. Moreover, we will analyze virus involvement in glomerulonephritis and in IgA nephropathy, theorizing the molecular mechanisms that may be responsible for the crosslink with these renal diseases.

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Coronavirus disease 2019, vaccination against coronavirus and immunoglobulin A-mediated diseases: systematic literature review

Cited by 7 publications

References 79 publications

Bioinformatics and system biology approach to identify the influences of SARS-CoV-2 on metabolic unhealthy obese patients

Bioinformatics and system biology approach to identify the influences of SARS-CoV-2 on metabolic unhealthy obese patients

Immunoglobulin A vasculitis: The clinical features and pathophysiology

The Human Virome and Its Crosslink with Glomerulonephritis and IgA Nephropathy

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