Objectives: In this study; ıt was aimed to determine the effect of nursing students' attitudes towards the profession on career adaptability and optimism. Methods: The universe of the descriptive and cross-sectional research; all students studying in the nursing department of a state university in the Mediterranean region (N:400). 246 students were sampled. In this study, "Personal Data Form", "Attitude towards Nursing Profession" and "Career Future" scales were used while collecting data. Data were analyzed using the "Independent Sample-t", "Mann-Whitney U", "One-Way Anova" and "Kruskal-Wallis H" tests. Results: In this study, it was determined that 65.1% of the students were female, their mean age was 21.26±2.05 years, 31.7% were in the 4th grade, and 58.6% had a medium income. 43% of the students preferred the nursing profession because of the ease of finding a job. 71.9% of them made a career plan after graduation; 95.6% stated that they want to receive career planning training. In the study, the relationship between the HMYTÖ-total score and career adaptability, career optimism, knowledge sub-dimension and KARGEL-total score was statistically significant (p<0.05). Conclusion: It was found that professional attitude affects career optimism and career adaptability.