Hemostatic potential of the sap of Musa sapientum L. (Musaceae)

Abstract

In Benin, Musa sapientum is one of the most important medicinal species used in the treatment of bleeding. In this study, hemostatic properties of M. sapientium sapand its mechanism of action have been identified through hematologic tests such as Clotting Time, Prothrombin Time, Activated Partial Thromboplastin Time and Milk Precipitation Test; biochemical test (total proteins); macroscopic and microscopic tests performed on different blood products before and after addition of sap. The results obtained showed that Musa sapientum reduced significantly clotting Time. However, it has no effect on the individual factors of coagulation. Its mechanism of action results from its ability to form a protein network which is a basis for cellular aggregation stopping bleeding. Moreover, Milk Precipitation Test showed astringent properties of Musa sapientum and therefore its vasoconstrictors properties. Phytochemical analyses revealed the presence of alkaloids, tannins, coumarins, reducing compounds, anthocyanins and leucoantocyanes. . M. sapientumis great on treatment of bleeding and could help to elaborate new drugs.

Hemostatic Effect of Jatropha multifida L. (Euphorbiaceae) in Rats Having Coagulation Disorders

“…Gallic tannins contained in SJM [11] would play an important role in the formation of the protein network. Their involvement in coagulation was previously reported by Klotoé et al [19] and Dandjesso et al, [20] during work on extracts of haemostatic plants. Since SJM causes proteinbased coagulation without affecting coagulation factors, it has an advantage over other hemostatics that activates the classical pathways of hemostasis [15], [21].…”

The effect of papaya leaf extract (Carica papaya l.) to the bleeding time on mice with trombositopenia

“…Some of these compounds are flavonoids and tannins. The mechanism of tannin in stopping bleeding is through its astringent effect (14). Flavonoid compounds can stop bleeding with vasoconstriction mechanisms in blood vessels (15).…”

Histomorphometric study of ethanolic extract of Graptophyllum pictum (L.) Griff. leaves on croton oil-induced hemorrhoid mice: A Javanese traditional anti-hemorrhoid herb

“…Astringent activity-induced vasoconstriction was an essential factor in hemostasis (Nabavizadeh et al, 2016). Astringency activity was determined using the milk precipitation method (Dandjesso et al, 2012;Klotoé et al, 2012). Briefly, 1 mL of GPLE solution (5%) was put in the tube, added with 100 μL milk and homogenized, allowed to stand for 3 min, and centrifuged for 1 min at 3000 rpm.…”