Hemostatic Biomarkers and Cancer Prognosis: Where Do We Stand?

Falanga, Anna; Marchetti, Marina; Russo, Laura

doi:10.1055/s-0041-1733925

Cited by 13 publications

(13 citation statements)

References 107 publications

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“…Increased levels of clotting factors, leukocytes, platelets, and TF-positive microparticles are all potential factors that alone or in combination increase CAT [30]. After activation of coagulation system, fibrin-related markers, such as D-dimer, SF and FDP are increased, and these biomarkers are used for the diagnosis and exclusion of VTE [31,32]. The platelet activation receptor C-type lectin-like receptor 2 (CLEC-2), and its endogenous ligand podoplanin have attracted the attention of many researchers [33].…”

Section: Discussionmentioning

confidence: 99%

Detection of a Hypercoagulable State in Patients With Pancreatic Cancer Using a Clot Waveform Analysis

Kobayashi¹,

Wada²,

Fukui³

et al. 2023

Preprint

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Background: The patients with cancer, especially pancreas cancer, are frequently associated with thrombosis which is one of causes for poor outcome, and hypercoagulability exists in cancer patients. Hypercoagulability is considered to be caused by thrombin burst. Methods: Activated partial thromboplastin time (APTT), small amount of tissue factor induced FIX activation (sTF/FIXa) assays and thrombin time (TT) using clot waveform analysis (CWA) were performed in 138 patients with malignant neoplasm including pancreas cancer and 66 non-cancer patients. Results: Thrombosis was frequently associated in pancreas cancer and was observed in stage I. CWA-APTT showed that the peak times and heights were markedly long and heigh, respectively, in cancer patients, and the peak times were significantly longer in pancreas cancer patients than benign pancreas diseases, and the 1st DPH was significantly higher in pancreas cancers than other cancers or benign pancreas diseases. CWA-sTF/FIXa showed that the peak times and heights were longer and higher, respectively, in patients with cancer than those without cancers, and that the 1st DPH was significantly higher in pancreas cancers than in other cancers. CWA-TT showed that the peak times were significantly shorter in cancer patients than in healthy volunteers and that the peak heights were significantly higher in cancer than in benign pancreas diseases. Conclusions: Cancer patients including pancreas cancer were frequently associated with thrombosis due to hypercoagulability with thrombin burst detected by CWA.

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Section: Discussionmentioning

confidence: 99%

Detection of a Hypercoagulable State in Patients With Pancreatic Cancer Using a Clot Waveform Analysis

Kobayashi¹,

Wada²,

Fukui³

et al. 2023

Preprint

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“…In addition, inflammation, abnormal coagulation, and nutritional status play important roles in the occurrence and development of tumors (26)(27)(28)(29), and neutrophils, platelets, and lymphocytes also contribute to tumor cell invasion into the peripheral blood, where they can survive and reseed in distant organs. Several prognostic scores based on inflammation and nutrition have been developed to predict survival and recurrence of cancer, such as NLR, PLR, and SII (30)(31)(32).…”

Section: Discussionmentioning

confidence: 99%

A retrospective study of clinicopathological characteristics and prognostic factors of Krukenberg tumor with gastric origin

Lin¹,

Han²,

Meng³

et al. 2022

J Gastrointest Oncol

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Background: Krukenberg tumor (KT) of gastric origin has a poor prognosis. The present study of KTs are mainly case reports and clinical analysis with few samples. Therefore, it is urgent to explore the clinicopathologic characteristics of KTs through large sample studies. To improve the understanding of the clinical diagnosis and treatment of KT, this paper retrospectively analyzed 10 years of gastric cancer (GC) database data, including clinicopathological and prognostic features, aiming to provide a clinical reference for the diagnosis and treatment of the tumor. Methods:The clinicopathological characteristics, treatments, and survival data were collected and analyzed from 130 patients with KTs of GC. Clinicopathological data included clinical manifestations, laboratory findings, imaging reports, pathology and immunohistochemistry (IHC) reports. We collected treatment regimens information on whether they had undergone surgery and chemotherapy and performed survival follow-up. Univariate and multivariate analysis were used to investigate the risk factors of KTs with gastric origin. Results:The median age of the patients was 41 years. A total of 63.1% of patients had synchronous ovarian metastasis, 70.8% had bilateral ovarian metastasis, 68.5% had peritoneum metastasis, and 98.5% had pathologically poorly differentiated adenocarcinoma. The positive rate of human epidermal growth factor receptor 2 (HER-2) was 1.8%. The follow-up rate was 90.8%, and the median overall survival (mOS) of ovarian metastasis was 13.0 months. Univariate analysis showed statistically significant prognostic factors including menstrual status, size of the gastric lesions and ovarian metastases, number of lymph node metastasis, interval to ovarian metastasis, resection of gastric lesions, peritoneal metastasis, oophorectomy, chemotherapy after ovarian metastases, two-drug regimen chemotherapy, albumin, serum cancer antigen 125 (CA-125) levels, platelet count, D-dimer, fibrinogen, and high pretreatment platelet-to-lymphocyte ratio (PLR) and systemic immune-inflammation index (SII). Fibrinogen [hazard ration (HR) =0.483; 95% confidence interval (CI): 0.300-0.777; P=0.003], size of ovarian metastasis (HR =1.808; 95% CI: 1.178-2.776; P=0.007), chemotherapy after ovarian metastasis (HR =0.195; 95% CI: 0.101-0.379; P=0.000), peritoneal metastasis (HR =2.742; 95% CI: 1.606-4.682; P=0.000) and oophorectomy (HR =1.720; 95% CI: 1.066-2.778; P=0.026) were independent prognostic factors.Conclusions: GC patients with KTs have some unique clinical features. Hypercoagulable states, peritoneal metastasis, and untimely chemotherapy and oophorectomy might be a worse predictor for KTs derived from gastric origin.

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“…In this study, 28.3% of patients with malignant neoplasm had thrombotic diseases, suggesting that these patients were in a hypercoagulable state. Patients with malignant neoplasm are frequently associated with thrombotic disorder and are considered to be in a hypercoagulable state [21]. Trousseaus syndrome has been shown in multiple published articles [22][23][24][25][26] to have a relationship between malignant neoplasms and thrombotic disease [6].…”

Section: Discussionmentioning

confidence: 99%

A Clot Waveform Analysis Showing a Hypercoagulable State in Patients with Malignant Neoplasms

Kobayashi

Wada

Fukui

et al. 2021

JCM

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(1) Objective: hypercoagulability in patients with malignant neoplasm were evaluated to examine the relationship with thrombosis. (2) Methods: clot waveform analysis (CWA)—activated partial thromboplastin time (APTT) and CWA—small amount of tissue factor induced FIX activation (sTF/FIXa) assays were performed in 92 patients with malignant neoplasm and the relationship between hypercoagulability and thrombosis was retrospectively examined. (3) Results: The study population included 92 patients with malignant neoplasms. Twenty-six (28.3%) had thrombotic diseases and 9 (9.8%) patients died within 28 days after the CWA. The peak time of the CWA-APTT could not show hypercoagulability in patients with malignant neoplasms. There were almost no significant differences in the peak times of the sTF/FIXa among patients with malignant neoplasms and healthy volunteers. In contrast, the peak heights of the CWA-sTF/FIXa in patients with various malignant neoplasms were significantly higher than those in healthy volunteers. Furthermore, among patients with malignant neoplasms, the peak heights of the sTF/FIXa in patients with thrombosis were significantly higher than those in patients without thrombosis. (4) Conclusions: although the routine APTT cannot evaluate the hypercoagulability, the peak heights of CWA-sTF/FIXa were significantly high in patients with malignant neoplasms, especially in those with thrombosis, suggesting that an elevated peak height of the CWA-sTF/FIXa may be a risk factor for thrombosis.

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Hemostatic Biomarkers and Cancer Prognosis: Where Do We Stand?

Cited by 13 publications

References 107 publications

Detection of a Hypercoagulable State in Patients With Pancreatic Cancer Using a Clot Waveform Analysis

Detection of a Hypercoagulable State in Patients With Pancreatic Cancer Using a Clot Waveform Analysis

A retrospective study of clinicopathological characteristics and prognostic factors of Krukenberg tumor with gastric origin

A Clot Waveform Analysis Showing a Hypercoagulable State in Patients with Malignant Neoplasms

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