A Clot Waveform Analysis Showing a Hypercoagulable State in Patients with Malignant Neoplasms

Kobayashi, Mizuho; Wada, Hideo; Fukui, Shunsuke; Mizutani, Hiroki; Ichikawa, Yuhuko; Shiraki, Katsuya; Moritani, Isao; Inoue, Hidekazu; Shimaoka, Motomu; Shimpo, Hideto

doi:10.3390/jcm10225352

Cited by 11 publications

(14 citation statements)

References 30 publications

(51 reference statements)

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“…The CWA-sTF/FIXa showed extremely high peak heights in patients with cancer associated with thrombosis, 20 suggesting that for evaluating hypercoagulability, CWA-APTT or CWA-sTF/FIXa using the peak heights is more useful than that using the peak times. The peak height of the CWA-APTT was also reported to be useful in cases of hemophilia.…”

Section: Discussionmentioning

confidence: 99%

The Detection of Hypercoagulability in Patients with Acute Cerebral Infarction Using a Clot Waveform Analysis

Kamon

Horie

Inaba

et al. 2023

Clin Appl Thromb Hemost

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A few studies concerning hypercoagulable states have sufficiently been reported in patients with acute cerebral infarction (ACI), as ACI is generally considered to be caused by platelet activation. Clot waveform analyses (CWA) for activated partial thromboplastin time (APTT) and small amount of tissue factor FIX activation assay (sTF/FIXa) were examined in 108 patients with ACI, 61 patients without ACI, and 20 healthy volunteers. CWA-APTT and CWA-sTF/FIXa showed that the peak heights were significantly higher in ACI patients without anticoagulant therapy than in healthy volunteers. Absorbance exceeding 78.1 mm on the 1st DPH in the CWA-sTF/FIXa showed the highest odds ratio for ACI. The peak heights were significantly lower in the CWA-sTF/FIXa of ACI patients receiving argatroban therapy than in those of ACI patients without anticoagulant therapy. CWA can suggest a hypercoagulable state in ACI patients and may be useful for monitoring the need for anticoagulant therapy.

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Section: Discussionmentioning

confidence: 99%

The Detection of Hypercoagulability in Patients with Acute Cerebral Infarction Using a Clot Waveform Analysis

Kamon

Horie

Inaba

et al. 2023

Clin Appl Thromb Hemost

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“…These parameters are also good predictors of the bleeding tendency in hemophilia A patients, as they correlate well with factor VIII activity [11]. On the contrary, CWA has not been well described as a tool to evaluate a hypercoagulable state, although emerging literature shows promising evidence that it may be useful to detect a procoagulable state [12,13].…”

Section: Discussionmentioning

confidence: 99%

Clot waveform analysis in acute promyelocytic leukemia

Terras,

El Borgi,

Betbout

et al. 2023

Blood Coagulation &Amp; Fibrinolysis

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The aim of this study was to evaluate the activated partial thromboplastin time (APTT) and prothrombin time (PT)-based clot waveform analysis (CWA) in patients diagnosed with acute promyelocytic leukemia (APL). APTT-based and PT-based CWA parameters of patients diagnosed with APL were analyzed and compared with healthy volunteers. Four APTT-CWA parameters were noted, maximum velocity corresponding to the first peak of the first derivative (max1), maximum acceleration corresponding to the first peak of the second derivative (max2) and the corresponding peak times of max1 and max2 (Tmax1, Tmax2). For the PT-CWA, two PT-CWA parameters were noted, maximum velocity (max1’) and the corresponding timing (Tmax1’). The results were expressed in medians. Mann–Whitney U test was used to compare the CWA parameters. Correlations were examined using the Spearman correlation test. Tmax1 and Tmax2 were significantly prolonged in patients with APL in comparison with healthy volunteers. Although max1 and max2 were lower in APL patients compared with healthy volunteers, no significant difference was noted. There was a strong and significant correlation between the DIC score and the parameters max1, max2 and max1’ and a very strong and significant correlation between fibrinogen levels and max1, max2 and max1’. When comparing DIC patients with hypofibrinogenemia and DIC without hypofibrinogenemia, a significant difference was noted in max1, max2, Tmax1 and Tmax2. The APTT and PT-based CWA analysis is a good tool to evaluate the bleeding tendency in APL, as it offers a novel approach for evaluating global hemostasis, predicting the bleeding risk and delivering improvements to APL patients management.

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“…Microvesicle-associated thrombin generation in ITP patients was reported to be increased after the initiation of thrombopoietin receptor agonists [25]. The CWA-sTF/FIX assay is simple and easy assay and is useful for diagnosing not only ITP but also hypercoagulability [26].…”

Section: Discussionmentioning

confidence: 99%

Clot Waveform Analysis Demonstrates Low Blood Coagulation Ability in Patients with Idiopathic Thrombocytopenic Purpura

Wada

Ichikawa

Ezaki

et al. 2021

JCM

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Background: Although platelets, which contain large amounts of phospholipids, play an important role in blood coagulation, there is still no routine assay to examine the effects of platelets in blood coagulation. Methods: Hemostatic abnormalities in patients with thrombocytopenia, including those with idiopathic thrombocytopenic purpura (ITP), were examined using clot wave analysis (CWA)–small-amount tissue-factor-induced FIX activation (sTF/FIXa) and thrombin time (TT). Results: Although there were no marked differences in the three parameters of activated partial thromboplastin time (APTT) between normal healthy volunteers and typical patients with ITP, the peak heights of the CWA-sTF/FIXa were markedly low in patients with ITP. The three peak times of the CWA-sTF/FIXa in patients with a platelet count of ≤8.0 × 1010/L were significantly longer than those in patients with a platelet count > 8.0 × 1010/L and the peak heights of the CWA-sTF/FIXa in patients with a platelet count of ≤8.0 × 1010/L were significantly lower than those in patients with >8.0 × 1010/L. The peak heights of the CWA-APTT in patients with ITP were significantly lower than in patients with other types of thrombocytopenia. The three peak heights of the CWA-sTF/FIXa in ITP patients were significantly lower than those in patients with other types of thrombocytopenia. The CWA-TT showed lower peak heights and longer peak times in patients with ITP in comparison to patients with other types of thrombocytopenia. Conclusions: The CWA-sTF/FIXa and CWA-TT results showed that blood coagulation is enhanced by platelets and that the blood coagulation ability in ITP patients was low in comparison to healthy volunteers and patients with other types of thrombocytopenia.

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A Clot Waveform Analysis Showing a Hypercoagulable State in Patients with Malignant Neoplasms

Cited by 11 publications

References 30 publications

The Detection of Hypercoagulability in Patients with Acute Cerebral Infarction Using a Clot Waveform Analysis

The Detection of Hypercoagulability in Patients with Acute Cerebral Infarction Using a Clot Waveform Analysis

Clot waveform analysis in acute promyelocytic leukemia

Clot Waveform Analysis Demonstrates Low Blood Coagulation Ability in Patients with Idiopathic Thrombocytopenic Purpura

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