Hemorrhagic Fever with Renal Syndrome, Russia

Abstract

In Russia, 131,590 cases of hemorrhagic fever with renal syndrome caused by 6 different hantaviruses were reported during 2000–2017. Most cases, 98.4%, were reported in western Russia. The average case-fatality rate was 0.4%, and strong regional differences were seen, depending on the predominant virus type.

Comprehensive risk assessment of epidemiological situation aggravation as regards natural-focal infectious diseases during the XXI FIFA world cup in the Russian Federation in 2018

“…Among all HFRS cases across the country, PFD rates amounted to 86.4 %. It testified to the fact that PFD was characterized by the most serious potential epidemic hazard as regards HFRS in Russia [3]. HFRS incidence is registered here annually.…”

Various Adjuvants Effect on Immunogenicity of Puumala Virus Vaccine

“…The disease is widespread in Eurasia, and in Russia occupies a leading position among all natural focal human diseases. More than 97% of HFRS cases in the Russian Federation are caused by the Puumala virus (PUUV), and about 3% of cases are caused by the Hantaan, Amur, Seoul, Kurkino, and Sochi viruses (Tkachenko et al, 2016a;Tkachenko et al, 2016b;Tkachenko et al, 2019). Monovalent and bivalent inactivated vaccines based on the epidemiologically significant strains of the Puumala and Kurkino viruses were developed in Russia (Barkhaleva et al, 2011;Tkachenko et al, 2015), and polyvalent vaccine based on the Puumala, Hantaan and Sochi viruses, which successfully passed preclinical tests (Sinyugina et al, 2019).…”

Pre-Clinical Studies of Inactivated Polyvalent HFRS Vaccine

“…Hemorrhagic fever with renal syndrome (HFRS) is a non-transmissible viral zoonosis widespread in Eurasia. In Russia HFRS is one of the most important natural focal human diseases ( Tkachenko et al., 2019 ). The causative agents of HFRS are the orthohantaviruses Puumala , Seoul, Hantaan (Hantaan, Amur, Suchong viruses), Dobrava-Belgrade (Dobrava, Sochi, Kurkino, and Saaremaa viruses) 1 .…”

“…The causative agents of HFRS are the orthohantaviruses Puumala , Seoul, Hantaan (Hantaan, Amur, Suchong viruses), Dobrava-Belgrade (Dobrava, Sochi, Kurkino, and Saaremaa viruses) 1 . In Russia, HFRS is caused by Puumala (PUUV), Hantaan (HTNV), Seoul, Kurkino, and Sochi (SOCHI) viruses ( Tkachenko et al., 2019 ). HFRS cases are registered in 68 out of 85 regions of the Russian Federation and annually comprise 6,000–11,000 patients 2 .…”

“…In 570 patients with HFRS, the disease was fatal. More than 98% of HFRS cases were detected in the European part, the vast majority of which (more than 98%) caused by the Puumala virus ( Tkachenko et al., 2019 ). In the late 1990s, in the forest-steppe zone of the central regions of Russia, the Kurkino virus foci (the genetic variant of the Dobrava-Belgrade orthohantavirus) were established ( Tkachenko et al., 2005a ).…”