Pre-Clinical Studies of Inactivated Polyvalent HFRS Vaccine

Dzagurova, Tamara K.; Siniugina, Alexandra A.; Ишмухаметов, А. А.; Егорова, М.А.; Курашова, С. С.; Баловнева, М. В.; Deviatkin, Andrei A.; Tkachenko, Petr; Leonovich, O. A.; Ткаченко, Е А

doi:10.3389/fcimb.2020.545372

Cited by 12 publications

(5 citation statements)

References 22 publications

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“…Antibodies were detectable 33 months after vaccination. Recently, pre-clinical studies of inactivated polyvalent HFRS vaccine demonstrated the activation of a balanced immune response to PUUV, HNTV, and DOBV [ 190 ].…”

Section: Vaccines and Prevention Of Hantavirus Infectionsmentioning

confidence: 99%

Hemorrhagic Fever with Renal Syndrome in Asia: History, Pathogenesis, Diagnosis, Treatment, and Prevention

Sehgal

Mehta

Sahay

et al. 2023

Viruses

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Hemorrhagic Fever with Renal Syndrome (HFRS) is the most frequently diagnosed zoonosis in Asia. This zoonotic infection is the result of exposure to the virus-contaminated aerosols. Orthohantavirus infection may cause Hemorrhagic Fever with Renal Syndrome (HRFS), a disease that is characterized by acute kidney injury and increased vascular permeability. Several species of orthohantaviruses were identified as causing infection, where Hantaan, Puumala, and Seoul viruses are most common. Orthohantaviruses are endemic to several Asian countries, such as China, South Korea, and Japan. Along with those countries, HFRS tops the list of zoonotic infections in the Far Eastern Federal District of Russia. Recently, orthohantavirus circulation was demonstrated in small mammals in Thailand and India, where orthohantavirus was not believed to be endemic. In this review, we summarized the current data on orthohantaviruses in Asia. We gave the synopsis of the history and diversity of orthohantaviruses in Asia. We also described the clinical presentation and current understanding of the pathogenesis of orthohantavirus infection. Additionally, conventional and novel approaches for preventing and treating orthohantavirus infection are discussed.

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Section: Vaccines and Prevention Of Hantavirus Infectionsmentioning

confidence: 99%

Hemorrhagic Fever with Renal Syndrome in Asia: History, Pathogenesis, Diagnosis, Treatment, and Prevention

Sehgal

Mehta

Sahay

et al. 2023

Viruses

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“…A complex of virological, immunological and molecular genetic methods was used to detect orthohantaviruses and specific antibodies in HFRS patients and small mammals [35,39,45,[57][58][59].…”

Section: Specific Laboratory Diagnostics Of Hfrsmentioning

confidence: 99%

Cases of Hemorrhagic Fever with Renal Syndrome in Russia during 2000–2022

Ткаченко

Курашова

Балкина

et al. 2023

Viruses

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During 2000–2022, a total of 69 of Russia’s 85 administrative regions reported 164,580 hemorrhagic fever with renal syndrome (HFRS) cases, with an annual average rate of 4.9 cases/100,000 population (105 popul.). European Russia reported 162,045 (98.5%) cases in 53/60 regions with 9.7 cases/105 popul. Asian Russia reported 2535 (1.5%) cases in 16/25 regions with 0.6 cases/105 popul. In the same period, Russia reported 668 (0.4%) fatal HFRS cases, and 4030 (2.4%) cases among children under the age of 14 years. Most HFRS cases occurred during autumn and winter. The incidence among rural residents was 6.7 per 105 popul., higher than the urban 4.4 per 105 popul.; however, among HFRS patients, rural and urban residents account for 35% and 65%, respectively. Six hantaviruses, causing HFRS of different clinical severity, were recognized as pathogens: Hantaan (HTNV) and Amur (AMUV) of Orthohantavirus hantanense species, Seoul (SEOV) of Orthohantavirus seoulense species, Puumala (PUUV) of Orthohantavirus puumalaense species, and Kurkino (KURV) and Sochi (SOCV) of Orthohantavirus dobravaense species, with the principal hosts Apodemus agrarius coreae, Apodemus peninsulae, Rattus norvegicus, Myodes glareolus, Apodemus agrarius agrarius, and Sylvaemus ponticus, respectively. It was found that 97.7% of HFRS cases are caused by PUUV, therefore, this virus plays the main role in the HFRS morbidity structure in Russia.

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“…IL-6 непосредственно участвует в стимуляции пролиферации В-клеток и активации тромбоцитопоэза. В совокупности, повышенный уровень указанных выше цитокинов в сыворотке крови пациентов обеспечивает активацию иммуногенных реакций с участием лимфоцитов типа Th1, а также стимуляцию процесса образования тромбоцитов [23]. Лабораторные данные подтверждают эти данные: у пациентов с ГЛПС обнаружены циркулирующие CD8 + лимфоциты, повышенный уровень в сыворотке крови антител к хантавирусу, а также признаки активации тромбоцитопоэза.…”

Section: обзорunclassified

Molecular aspects of the pathogenesis of hemorrhagic fever with renal syndrome

Галимова,

Литвицкий,

Галимова

et al. 2023

Zhurnal «Patologicheskaia Fiziologiia I Eksperimental`naia Terapiia»

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Цель обзора – анализ современных данных о механизмах развития геморрагической лихорадки с почечным синдромом (ГЛПС). Дана характеристика зоонозной инфекции, структуры и уровней заболеваемости в различных регионах мира. Инициальным патогенетическим звеном этой формы патологии, после инфицирования хантавирусом, является репликация вируса в эпителии верхних дыхательных путей c их повреждением и последующей активацией альвеолярных макрофагов и дендритных клеток. Дисфункция эндотелиальных клеток приводит к нарушению целостности стенок микрососудов, активации факторов системы иммунобиологического надзора за постоянным и индивидуальным антигенным составом организма и сопровождается расстройством состояния системы гемостаза. Это инициирует агрегацию тромбоцитов с активацией процесса тромбообразования и развитием осложнений в виде ДВС-синдрома и острой почечной недостаточности. Обсуждаются факты тесного взаимодействия в этом процессе различных классов цитокинов с тромбоцитами. Активация цитокинов наблюдается уже на ранних этапах заболевания. Об этом свидетельствует повышение в крови уровней интерферона γ (IFN-γ), фактора некроза опухоли α (ФНО-α), трансформирующего фактора роста β (ТФР-β), интерлейкинов: IL-6, IL-21 и IL-10, что коррелирует с тяжестью состояния пациента. Экстремальные уровни IL-6, IL-10 и IFN-γ сочетаются с развитием геморрагической лихорадки с высокой летальностью. Анализируются фактические данные о роли и месте в патогенезе ГЛПС микроРНК, обсуждаются перспективы их использования в качестве потенциальных биомаркеров прогноза развития заболевания и эффективности терапии ГЛПС. Расшифровка закономерностей динамики содержания в крови пациентов с ГЛПС различных регуляторных молекул будет способствовать пониманию механизмов развития заболевания, а также разработке принципов и методов лечения и профилактики этой тяжелой формы патологии человека. This review focuses on the mechanisms of development of hemorrhagic fever with renal syndrome (HFRS). A brief description of this zoonotic infection, the structure and values of its incidence are provided for various regions of the world. Following the infection with hantavirus, the disease starts from the virus replication in cells of the upper respiratory tract, their damage, and subsequent activation of alveolar macrophages and dendritic cells. Dysfunction of endothelial cells results in disturbed integrity of microvascular walls, activation of the immunobiological surveillance over the constant and individual antigenic composition of the body, and hemostatic disorders. This initiates platelet aggregation with the activation of thrombus formation and the development of complications in the form of disseminated intravascular coagulation (DIC) and acute renal failure. Cytokines, chemokines, and platelets have been demonstrated to closely interact in this process. Cytokine activation is noted already in early stages of the disease in association with increased levels of interferon γ (IFN-γ), tumor necrosis factor α, transforming growth factor β, and interleukins IL-6, IL-21 and IL-10, which correlates with severity of the patient’s condition. Extremely high levels of IL-6, IL-10, and IFN-γ contribute to the development of severe hemorrhagic fever with a high mortality rate. The review also provides information on the role and place of microRNAs in the pathogenesis of HFRS and the prospects for their use as potential biomarkers for predicting the disease development and the effectiveness of therapy. Studying the dynamics of changes in the content of various regulatory molecules in the blood of patients with HFRS will provide new data on mechanisms of the disease and help development of treatment and prevention of this severe pathology.

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Pre-Clinical Studies of Inactivated Polyvalent HFRS Vaccine

Cited by 12 publications

References 22 publications

Hemorrhagic Fever with Renal Syndrome in Asia: History, Pathogenesis, Diagnosis, Treatment, and Prevention

Hemorrhagic Fever with Renal Syndrome in Asia: History, Pathogenesis, Diagnosis, Treatment, and Prevention

Cases of Hemorrhagic Fever with Renal Syndrome in Russia during 2000–2022

Molecular aspects of the pathogenesis of hemorrhagic fever with renal syndrome

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