HEMOPOIETIC STEM CELL PROLIFERATION AND MIGRATION FOLLOWING <i>BORDETELLA PERTUSSIS</i> VACCINE

Monette, Francis C.; Morse, Bernard S.; Howard, Donald; Niskanen, Eero; Stohlman, Frederick

doi:10.1111/j.1365-2184.1972.tb01009.x

Cited by 25 publications

(16 citation statements)

References 16 publications

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“…If this is so, the C. parvurn-induced rise in the (Table V). Similar results have been reported by Monette et al (1972) in B. pertussis-treated mice. This finding indicates that the CFUs accumulating in the spleen should be of exogenous origin, derived probably from bone marrow.…”

Section: Discussionsupporting

confidence: 91%

Effect of Corynebacterium parvum on hemopoietic stem‐cell kinetics

Eliopoulos

Andre

Anagnou

et al. 1979

Intl Journal of Cancer

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The intravenous administration of 548 microgram of killed Corynebacterium parvum (C. parvum) into C57BL mice leads to a significant decrease in the number of bone-marrow colony-forming-units in spleen (CFUs) as early as 12 h after the injection of the bacterium. This decrease persisted in varying degrees for 3 weeks. After an initial fall at 24 h, the splenic CFUs exhibited a rapid expansion and reached values 10 times higher than the control range on the ninth day. A significant rise in the number of circulating CFUs, reaching a first peak at 2 h and a second one on the fifth day, was also observed. The proliferative status of femoral CFUs was increased at 48 and 72 h, while that of splenic CFUs presented a significant increase only 48 h after the injection of C. parvum. The sequence of events which were observed in these experiments indicates that an accelerated migration of hemopoietic stem cells from bone marrow to spleen via the blood circulation has to take place.

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Section: Discussionsupporting

confidence: 91%

Effect of Corynebacterium parvum on hemopoietic stem‐cell kinetics

Eliopoulos

Andre

Anagnou

et al. 1979

Intl Journal of Cancer

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“…of 20X109 heat killed B. pertussis organisms. In normal mice, this treat ment effects a rapid fall of marrow erythroid precursors and a sharp in crease in the number of circulating C F U [7], In the present study, a 6.5-fold increase in blood C F U concentration in + / + mice was observed, while in Sl/Sld mice there was only a 2.4-fold increase (table I). The ob served increase in + / + mice was distributed among the various colony types.…”

Section: Resultssupporting

confidence: 52%

Erythrocytic Committed Hematopoietic Stem Cells in the Peripheral Blood of Mice

McCarthy¹,

MacVittie²

1975

Acta Haematol

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“…Thus, in re sponse to the increased demand for certain blood cells, hemopoietic stem cells are mobilized via the bloodstream from bone marrow to various extra medullar hemopoietic organs where they undergo growth/differentiation. Mobilization of CFU-S into the circulation in response to the increased demand for neutrophils was already noted in mice treated with pertussis vaccine [15] or with bacterial endotoxin [16].…”

Section: Discussionmentioning

confidence: 75%

Effects of <i>Toxocara canis </i>Infection on Hemopoietic Stem Cells and Hemopoietic Factors in Mice

Higa

Maruyama²,

Abe³

et al. 1990

Int Arch Allergy Immunol

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The effects of Toxocara canis infection on hemopoietic stem cells and hemopoietic factors were examined in mice. Severe eosinophilia was observed with a peak 14 days after infection. When the numbers of hemopoietic stem cells in peripheral blood, spleen, and bone marrow were examined by spleen colony assay (CFU-S), those in peripheral blood and spleen increased in parallel with peripheral blood eosinophilia. On the other hand, CFU-S in bone marrow did not alter significantly throughout the course of infection. Interleukin (IL)-3, which is known as multi-colony-stimulating factor and is involved in the growth/differentiation of various blood cells including stem cells, was produced by spleen cells of infected mice. The time course study showed that concanavalin A stimulated IL-3 production peaked on day 7 after infection, whereas that with excretory secretory antigen peaked on day 14. Even without stimulation, spleen cells obtained on day 21 after infection produced IL-3 spontaneously. IL-5, which is known to have eosinophil differentiation factor activity, was also produced by spleen cells obtained on day 13 after infection. These results suggest that in response to increased demand for eosinophils, hemopoietic stem cells migrate into various extramedullar hemopoietic organs where they grow/differentiate into mature eosinophils, depending on the hemopoietic factors.

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HEMOPOIETIC STEM CELL PROLIFERATION AND MIGRATION FOLLOWING BORDETELLA PERTUSSIS VACCINE

Cited by 25 publications

References 16 publications

Effect of Corynebacterium parvum on hemopoietic stem‐cell kinetics

Effect of Corynebacterium parvum on hemopoietic stem‐cell kinetics

Erythrocytic Committed Hematopoietic Stem Cells in the Peripheral Blood of Mice

Effects of <i>Toxocara canis </i>Infection on Hemopoietic Stem Cells and Hemopoietic Factors in Mice

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