Hemolytic Uremic Syndrome

Hemolytic uremic syndrome linked to infectious mononucleosis

“…Nonetheless, no stool testing for germs harboring genes for shigatoxin was performed [5]. It is therefore tempting to assume that these patients had concurrent infectious mononucleosis caused by Epstein-Barr virus and classic hemolytic uremic syndrome caused by micro-organisms that produce shigatoxin [1,2]. In our patient the history and the laboratory values strongly argue against a causal link between pathogens that produce shigatoxin and hemolytic uremic syndrome.…”

“…Nonetheless there is little question that he did have both infectious mononucleosis [6,7] and hemolytic uremic syndrome [1,2].…”

“…Invasive infections with neuraminidase-producing Strepotococcus pneumoniae are a further rather rare but well-recognized cause of hemolytic uremic syndrome [3,4]. In the remaining 10%-30% of cases, the etiology of hemolytic uremic syndrome remains a matter of discussion, but has sometimes been attributed to viral infections [1]. We report an infant with hemolytic uremic syndrome and infectious mononucleosis.…”

“…In childhood, hemolytic uremic syndrome mostly follows an acute diarrheal prodrome caused by shigatoxinproducing strains of Escherichia coli or Shigella dysenteriae type 1 [1,2]. Invasive infections with neuraminidase-producing Strepotococcus pneumoniae are a further rather rare but well-recognized cause of hemolytic uremic syndrome [3,4].…”

A case of atypical hemolytic uremic syndrome with a transient decrease in complement factor H

“…Hemolytic uremic syndrome (HUS), a heterogeneous group of disorders characterized by microangiopathic hemolytic anemia, thrombocytopenia, and azotemia, is a major cause of acute renal failure in children [1]. Most children with HUS experience a diarrhea prodrome caused by Shiga toxin (Stx) producing E. coli [diarrheapositive (D+) HUS], and most D+ HUS patients experience complete recovery of renal function within 2-3 weeks.…”