Hemolytic uremic syndrome linked to infectious mononucleosis

Abstract

A 12-month-old boy developed a mild hemolytic uremic syndrome with no acute diarrheal prodrome. The typical clinical, hematological, and serological features of infectious mononucleosis were also noted. The clinical course of both hemolytic uremic syndrome and infectious mononucleosis was uneventful. A review of the literature disclosed that hemolytic uremic syndrome has been noted in two adolescents with infectious mononucleosis.

Hemolytic-uremic syndrome in Switzerland: a nationwide surveillance 1997–2003

“…In one previously reported patient the disease complicated an acute infectious mononucleosis [28], while in two patients atypical HUS occurred as a consequence of cobalamin C disease and factor H deficiency, respectively. Classification was not possible in the remaining three patients.…”

Hemolytic uremic syndrome; pathogenesis, treatment, and outcome

“…A report of HUS occurring in a 12-month-old infant with infectious mononucleosis [7] is the third such reported association, though the pathogenesis remains obscure. There are two recent reports of Q fever (C. burnetti, infection) [8,9], one in Greece and the other in Canada, associated with HUS.…”

Hemolytic uremic syndrome associated with Epstein-Barr virus infection

“…Sirs, I read with interest the article, entitled "Hemolytic uremic syndrome linked to infectious mononucleosis" by Simonetti et al in this journal [1]. Several viruses are known to cause hemolytic uremic syndrome (HUS), including human immunodeficiency virus, enterovirus [2], influenza virus [3], and human parvovirus B19 [4].…”