Hemodynamic evaluation of the right portal vein in healthy dogs of different body weights

Abstract

BackgroundDoppler ultrasonography is an important tool for evaluating hepatic portal hemodynamics. However, no study in dogs of different body weights, in the range encountered in routine clinical veterinary practice, has been reported. It can be difficult to obtain an ideal insonation angle when evaluating the main portal vein, so evaluation of the right portal vein branch has been described in humans as an alternative. The aim of this study was to analyze, through Doppler ultrasonography, the hemodynamics in the right portal vein branch in dogs of different body weights.MethodsThirty normal dogs were divided in three groups by weight, in order to establish normal values for mean velocity, flow volume and portal congestion index of the right portal vein branch by means of Doppler ultrasonography.ResultsIn all dogs ideal insonation angles were obtained for the right portal vein branch. The average velocity was similar in the three groups, but the portal congestion index and the flow volume differed, showing that the weight of the dog can influence these values.ConclusionDoppler ultrasonography for the evaluation of flow in the right branch of the portal vein could be a viable alternative, or complement, to examining the main vessel segment. This is especially so in those animals in which an ideal insonation angle for examination of the main portal vein is hard to obtain. In addition, the weight of the dog must be considered for the correct evaluation of the portal system hemodynamics, particularly for portal blood flow and the congestion index.

Canine gastrointestinal physiology: Breeds variations that can influence drug absorption

“…It is important to understand this diversity in order to predict the impact of drug product 31 formulation attributes on in vivo dissolution and absorption characteristics across the canine population 32 when the dog represents the targeted patient population. Based upon published information, this review 33 addresses breed differences in gastrointestinal (GI) physiology and discusses the in vivo implications of 34 these differences.…”

“…an assumption that hepatic blood flow does not vary as a function 257 of body weight or breed. This is an important consideration in light 258 of the work of Sartor et al [32] who showed the portal blood flow 259 volume (mL/min/kg) is inversely related to body weight. Therefore, [38].…”

Portal Vein Dopplerflowmetry in healthy sheep according to age

“…The study of hepatic vascular hemodynamics is important once changes can be detected when parenchymal liver diseases lead to changes in hepatic compliance (O'Donohue et al 2004) and in cases of vascular anomalies. Most of the studies reported in veterinary literature, however, are limited to Doppler sonography of the liver in healthy animals (Kantrowitz et al 1989, Lamb & Mahoney, 1994, Sartor et al 2010b) and for assessment of portosystemic shunts (D' Anjou et al 2004) in dogs and cats. Therefore, there is a need to investigate the applicability of liver Doppler ultrasound in sheep.…”

Sonographic Evaluation of Liver Hemodynamic Indices in Overweight and Obese Dogs

“…Color Doppler was used to visualize and identify liver vasculature. Mean portal velocity was measured in the right branch of portal vein when an ideal insonation angle could not be obtained in the main vessel, as previously reported . In all dogs, measurement of MPV was performed at angles of insonation <60°.…”