“…These drugs have profound dosedependent effects on the cardiovascular system characterized by peripheral vasoconstriction, bradycardia, and decrease in CO 2 (Savola, 1989;Vainio and Palmu, 1989;Flacke et al, 1990;Bloor et al, 1992;Golden et al, 1998). Therefore, it is logical to assume that these effects will also result in prolongation of the CT which, if not taken into consideration, may lead to overdosing of anaesthetic drugs (Hall et al, 2001).…”