Hemocompatible magnetic particles with broad-spectrum bacteria capture capability for blood purification

Shi, Zhenqiang; Jin, Lunqiang; He, Chao; Li, Yupei; Jiang, Chunji; Wang, Hui; Zhang, Jue; Wang, Jingxia; Zhao, Weifeng; Zhao, Changsheng

doi:10.1016/j.jcis.2020.04.115

Cited by 31 publications

(26 citation statements)

References 42 publications

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“…A QAC (s-poly (2,3-dimethylmaleic anhydride) (melittin)-b-poly (2-hydroxyethyl methacrylate) was modified on a surface as a multistage polymer brush to combat bacterial infection [ 106 ]. However, these QAC-based surfaces tended to induce irritation and inflammation, which hindered their practical application in the biomedical field [ 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 ]. In contrast to antibacterial polymers, antibacterial peptides hold great potential to solve the issues of irritation and inflammation and reduce the possibility of induced resistance.…”

Section: Bioinspired Antibacterial Surfacesmentioning

confidence: 99%

Recent Progress on Bioinspired Antibacterial Surfaces for Biomedical Application

et al. 2022

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Surface bacterial fouling has become an urgent global challenge that calls for resilient solutions. Despite the effectiveness in combating bacterial invasion, antibiotics are susceptible to causing microbial antibiotic resistance that threatens human health and compromises the medication efficacy. In nature, many organisms have evolved a myriad of surfaces with specific physicochemical properties to combat bacteria in diverse environments, providing important inspirations for implementing bioinspired approaches. This review highlights representative natural antibacterial surfaces and discusses their corresponding mechanisms, including repelling adherent bacteria through tailoring surface wettability and mechanically killing bacteria via engineering surface textures. Following this, we present the recent progress in bioinspired active and passive antibacterial strategies. Finally, the biomedical applications and the prospects of these antibacterial surfaces are discussed.

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Section: Bioinspired Antibacterial Surfacesmentioning

confidence: 99%

Recent Progress on Bioinspired Antibacterial Surfaces for Biomedical Application

et al. 2022

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“…Polydopamine (PDA) can prevent the non-speci c binding of blood cells and platelets to micro/nanoparticles due to their strong hydrophilicity [16,17]. It is a highly adaptable polymer that can be used to coat a variety of materials in a single step through the oxidative self-polymerization of dopamine [18,19].…”

Section: Introductionmentioning

confidence: 99%

“…Because of its reactivity with amine and thiol functional groups, it can also be used to immobilize biomolecules to surfaces [18,20,21]. For example, a PDA coating has been used to immobilize antimicrobial imidazolium-based ionic liquid to MNPs for the removal of bacteria from blood [17]. Similarly, PDA has been used to coat MNPs for the functionalization of probe oligonucleotides [22].…”

Section: Introductionmentioning

confidence: 99%

Vancomycin-conjugated polydopamine-coated magnetic nanoparticles for molecular diagnostics of Gram-positive bacteria in whole blood

Abafogi

Wu²,

Lee

et al. 2022

Preprint

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Sepsis is caused mainly by infection in the blood with a broad range of bacterial species. It can be diagnosed by molecular diagnostics once compounds in the blood that interfere with molecular diagnostics are removed. However, this removal relies on ultracentrifugation. Immunomagnetic separation (IMS), which typically uses antibody-conjugated silica-coated magnetic nanoparticles (Ab-SiO2-MNPs), has been widely applied to isolate specific pathogens in various types of samples, such as food and environmental samples. However, its direct use in blood samples containing bacteria is limited due to the aggregation of SiO2-MNPs in the blood and inability to isolate multiple species of bacteria causing sepsis. Results: In this study, we report the synthesis of vancomycin-conjugated polydopamine-coated (van-PDA-MNPs) enabling preconcentration of multiple bacterial species from blood without aggregation. The presence of PDA and van on MNPs was verified using transmission electron microscopy, X-ray photoelectron spectroscopy and energy disruptive spectroscopy. Unlike van-SiO2-MNPs, van-PDA-MNPs did not aggregate in the blood. Van-PDA-MNPs were able to preconcentrate several species of Gram-positive bacteria in the blood, lowering the limit of detection (LOD) to 10 colony forming units/mL by polymerase chain reaction (PCR) and quantitative PCR. This is 10 times more sensitive than the LOD obtained by PCR and qPCR with the use of van-SiO2-MNPs. Conclusion: These results suggest that PDA-MNPs do not aggregate in blood and can be conjugated with receptors, thereby improving the sensitivity of molecular diagnostics for bacteria in blood samples.

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“…In this regard, the hybrid nanosystems based on magnetite nanoparticles (MGNPs) could represent an alternative, considering their accessible and versatile preparation, reduced toxicity as well as antimicrobial properties [ 13 , 14 , 15 , 16 ]. MGNPs were authorized as in vivo drug delivery platform, and as a result, several loaded systems with a good antimicrobial activity were recently reported [ 17 , 18 , 19 , 20 , 21 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

“…As a result, this paper focuses on the structural characterization and evaluation of the antibiofilm activity of two bioactive nanosystems based on [1,3,4]thiadiazolo [3,2- a ]pyrimidinium derivatives and Fe 3 O 4 @C 18 core@shell nanoparticles against Staphylococcus aureus , Pseudomonas aeruginosa and Candida albicans strains in order to develop a new strategy for preventing both formation and eradication of microbial biofilms formed on medical devices. This research is based on previous data concerning the antimicrobial activity of MGNPs [ 13 , 14 , 15 , 16 ] and synergy observed with antimicrobials [ 17 , 18 , 19 , 20 , 53 , 54 ], a strategy that could be used in order to develop valuable nanocarriers for a controlled or a targeted release of an active agent. The interaction between the MGNPs and the [1,3,4]thiadiazolo[3,2- a ]-pyrimidinium derivatives was facilitated by octadecanoic acid (C 18 ).…”

Section: Introductionmentioning

confidence: 99%

Anti-biofilm Fe3O4@C18-[1,3,4]thiadiazolo[3,2-a]pyrimidin-4-ium-2-thiolate Derivative Core-shell Nanocoatings

et al. 2020

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The derivatives 5,7-dimethyl[1,3,4]thiadiazolo[3,2-a]pyrimidin-4-ium-2-thiolate (1) and 7-methyl-5-phenyl[1,3,4]thiadiazolo[3,2-a]pyrimidin-4-ium-2-thiolate (2) were fully characterized by single-crystal X-ray diffraction. Their supramolecular structure is built through both π–π stacking and C=S–π interactions for both compounds. The embedment of the tested compounds into Fe3O4@C18 core-shell nanocoatings increased the protection degree against Candida albicans biofilms on the catheter surface, suggesting that these bioactive nanocoatings could be further developed as non-cytotoxic strategies for fighting biofilm-associated fungal infections.

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Hemocompatible magnetic particles with broad-spectrum bacteria capture capability for blood purification

Cited by 31 publications

References 42 publications

Recent Progress on Bioinspired Antibacterial Surfaces for Biomedical Application

Recent Progress on Bioinspired Antibacterial Surfaces for Biomedical Application

Vancomycin-conjugated polydopamine-coated magnetic nanoparticles for molecular diagnostics of Gram-positive bacteria in whole blood

Anti-biofilm Fe3O4@C18-[1,3,4]thiadiazolo[3,2-a]pyrimidin-4-ium-2-thiolate Derivative Core-shell Nanocoatings

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