Hemocompatibility, biodegradability and acute toxicity of acetylated cellulose nanocrystals of different types in comparison

Торлопов, М. А.; Дрозд, Н. Н.; Paderin, Nikita M.; Tarabukin, Dmitriy V.; Udoratina, E. V.

doi:10.1016/j.carbpol.2021.118307

Cited by 17 publications

(11 citation statements)

References 45 publications

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“…These nanoparticles have a high degree of crystallinity and supramolecular structure of cellulose II. An analysis of the biocompatibility of different types of CNC showed that partially acetylated pCNC has low toxicity and high hemocompatibility . This fact together with previous works showing the perspectives of Pickering emulsions stabilized by CNC for drug delivery makes pCNC very promising for the development of new delivery systems.…”

Section: Introductionmentioning

confidence: 73%

Anti-Alzheimer Drug Delivery via Pickering Emulsions Stabilized by Plate-like Cellulose Nanocrystals

Mikhaylov,

Torlopov,

Vaseneva

et al. 2023

Langmuir

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In this work, we studied for the first time the formation of olive oil emulsions in water stabilized by plate-like nanocrystals with the supramolecular structure of cellulose II (pCNC). Effects of storage, pCNC concentration, and NaCl on the stability and properties of Pickering emulsions, including the creaming index, droplet size, zeta potential, acid−base surface properties, and rheology, were studied. A significant influence of the shape of nanoparticles (compared to the classical rod-like shape) on the stability parameters and rheological characteristics of emulsions is shown. Plate-like cellulose nanocrystals at a concentration of 16 g/L are able to form delamination-resistant emulsions without added electrolytes. The viscosity of pCNC-stabilized emulsions tends to decrease with increasing electrolyte concentration in the system, which is not characteristic of rod-like CNC-stabilized emulsions. This effect in pCNC-stabilized emulsions assumedly can be associated both with weak mechanical engagement between drops due to the shape of stabilizer particles and with an insignificant participation of background electrolyte cations in the formation of interdroplet interactions. Therefore, the resulting aggregates are unstable and easily destroyed, even under weak mechanical stress. As a consequence, the acid−base properties of the pCNC surface are practically independent of the emulsion preparation method (with or without electrolyte) as well as the concentration of the background electrolyte. The reduced viscosity of pCNC-stabilized emulsions in the presence of an electrolyte, coupled with the absence of acute toxicity, allows us to recommend them as a convenient oral delivery system for fatsoluble, biologically active substances. Our emulsions carrying donepezil (an anti-Alzheimer drug) showed better performance than a solution of donepezil hydrochloride in preventing memory impairment tested on laboratory mice.

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Section: Introductionmentioning

confidence: 73%

Anti-Alzheimer Drug Delivery via Pickering Emulsions Stabilized by Plate-like Cellulose Nanocrystals

Mikhaylov,

Torlopov,

Vaseneva

et al. 2023

Langmuir

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“…13 (a) shows that hemolysis% of AFCNG samples at all concentrations is below 2%. This value is well below the limit for biomaterials according to ISO/TR 7406 [38,[44][45][46]. The nanosize of hydrogel is able to enter into the blood vessels and negative surface charge of AFCNG is stable which are suitable for transdermal drug delivery application.…”

Section: Biodegradationmentioning

confidence: 87%

Synthesis and characterization of amine functionalized cellulose nanogel for transdermal drug delivery

Arockiaraj

Sundaramoorthy

2023

Preprint

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This study presents the synthesis and characterization of an amine-functionalized cellulose nanogel (AFCNG) for potential biomedical applications. AFCNG was synthesized using a combination of acid hydrolysis, TEMPO oxidation, and EDC/NHS-mediated coupling via amide linkage. Biodegradable AFCNG was formulated with a mean size of 74 nm through a regeneration process. Characterization of AFCNG was performed using various techniques such as FTIR spectroscopy, XRD, XPS, Zeta potential, DLS, HRSEM and TGA. The results revealed that AFCNG was amorphous, highly stable in colloidal form, and had higher degradation temperature and water absorption capacity. Biodegradation of AFCNG was also assessed by incubating it with lysozyme for five weeks, which resulted in a degradation level of 83%. Furthermore, hemo-compatibility and cytotoxicity properties of AFCNG were evaluated, and the results showed that it was hemo-compatible and non-toxic to 3T3 cells by cellular morphology assessment with DAPI staining. Curcumin-loaded AFCNG exhibited high cytotoxicity to B16-F10 cells, suggesting its potential as a transdermal drug delivery system for skin cancer treatment. The study concluded that AFCNG possesses the necessary characteristics to serve as a carrier for transdermal drug delivery applications.

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“…They are non-toxic to our environment [ 123 ]. As a result, there is a need to increase the anti-solvent properties, decreasing toxicity and improving biodegradability [ 124 , 125 ]. This employed toxicity process is the most significant problem [ 126 ].…”

Section: Process and Product Toxicitymentioning

confidence: 99%

A Review on the Modification of Cellulose and Its Applications

et al. 2022

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The latest advancements in cellulose and its derivatives are the subject of this study. We summarize the characteristics, modifications, applications, and properties of cellulose. Here, we discuss new breakthroughs in modified cellulose that allow for enhanced control. In addition to standard approaches, improvements in different techniques employed for cellulose and its derivatives are the subject of this review. The various strategies for synthetic polymers are also discussed. The recent advancements in polymer production allow for more precise control, and make it possible to make functional celluloses with better physical qualities. For sustainability and environmental preservation, the development of cellulose green processing is the most abundant renewable substance in nature. The discovery of cellulose disintegration opens up new possibilities for sustainable techniques. Based on the review of recent scientific literature, we believe that additional chemical units of cellulose solubility should be used. This evaluation will evaluate the sustainability of biomass and processing the greenness for the long term. It appears not only crucial to dissolution, but also to the greenness of any process.

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Hemocompatibility, biodegradability and acute toxicity of acetylated cellulose nanocrystals of different types in comparison

Cited by 17 publications

References 45 publications

Anti-Alzheimer Drug Delivery via Pickering Emulsions Stabilized by Plate-like Cellulose Nanocrystals

Anti-Alzheimer Drug Delivery via Pickering Emulsions Stabilized by Plate-like Cellulose Nanocrystals

Synthesis and characterization of amine functionalized cellulose nanogel for transdermal drug delivery

A Review on the Modification of Cellulose and Its Applications

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