Hematologic Profile of Sepsis in Neonates: Neutrophil CD64 as a Diagnostic Marker

Bhandari, Vineet; Wang, Chao; Rinder, Christine S.; Rinder, Henry M.

doi:10.1542/peds.2007-1308

Cited by 153 publications

(146 citation statements)

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“…16 In this study, neutrophil levels in saliva and blood from the case group were significantly higher than those of the control group. Similar to other neonatal sepsis studies, 17,18 we found significantly increased neutrophil levels in subjects at risk of sepsis, as evidenced by the elevation of neutrophil CD64, a very sensitive marker. bhandari et al reported that the combination of CD64 with an absolute neutrophil amount had a high negative predictive value (93%) and sensitivity (95%) for sepsis markers.…”

Section: Discussionsupporting

confidence: 90%

“…bhandari et al reported that the combination of CD64 with an absolute neutrophil amount had a high negative predictive value (93%) and sensitivity (95%) for sepsis markers. 18 There have been several reports on TLR2 and TLR4 expression in newborn babies. Vieman et al conducted a TLR2 and TLR4 expression study on granulocytes and monocytes from the peripheral veins of 20 healthy adults and from the umbilical cord veins of 85 newborns (32 septic infants and 53 healthy infants).…”

Section: Discussionmentioning

confidence: 99%

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Neutrophil, TLR2, and TLR4 expression in newborns at risk of sepsis

Yunanto

Endharti

Widodo

2013

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Neutrophil, TLR2, and TLR4 expression in newborns at risk of sepsis

Yunanto

Endharti

Widodo

2013

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“…A cut point of 3.62 had a sensitivity of 75%, specificity of 77% and a negative predictive value of 96%. 48 Index values below the cut points could be used to support the discontinuation of antimicrobials. Advantages of this assay include the requirement for only 50 μL of blood and availability of results within hours of the specimen being obtained.…”

Section: Neutrophil Markersmentioning

confidence: 99%

Recent Developments and Current Issues in the Epidemiology, Diagnosis, and Management of Bacterial and Fungal Neonatal Sepsis

2013

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The definition of neonatal sepsis is complicated by the frequent presence of noninfectious conditions that resemble those of sepsis, especially in very low-birth-weight (VLBW) preterm infants and by the absence of optimal diagnostic tests. Although growth of an organism from a sterile site is the "gold standard" for definitive diagnosis, it is not always possible to isolate a causative pathogen. Invasive infections can occur in seemingly asymptomatic neonates. Therefore, assessment of history and risk factors in combination with diagnostic tests are used to identify neonates who are more likely to be infected.The definitions of early onset sepsis (EOS) and late onset sepsis (LOS) are subject to subspecialist variation. Many investigators, including those who participate in the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Neonatal Network and the Vermont Oxford Network, define EOS by the onset of signs/symptoms and an associated positive culture at or before 72 hours of life. LOS is characterized by the onset of symptoms consistent with sepsis at greater than 72 hours of life. These classifications of EOS and LOS reflect the differing etiologies and proposed pathophysiology of pathogens commonly associated with the timing of Keywords ► neonatal sepsis ► invasive candidiasis ► epidemiology ► management AbstractIdentifying neonates with sepsis is complicated by variability in clinical presentation. The incidence of early onset sepsis (EOS) resulting from invasive group B streptococcal (GBS) infections has been notably reduced by the widespread delivery of intrapartum antibiotic prophylaxis. Rates of EOS attributable to non-GBS etiologies have remained constant, and ampicillin-resistant Escherichia coli has become more prevalent. Lateonset sepsis (LOS) attributable to gram-positive organisms including coagulase-negative Staphylococci and Staphylococcus aureus is associated with increased morbidity and mortality among premature infants. Invasive candidiasis is an emerging cause of LOS, especially among infants who receive broad-spectrum antimicrobial agents. Prophylactic fluconazole administration to very low-birth-weight (VLBW) neonates during the first 6 weeks of life prevents invasive candidiasis in neonatal intensive care units (NICU) with high rates of fungal infections. Targeted fluconazole prophylaxis may be beneficial in VLBW neonates who receive care in NICUs with lower rates of invasive fungal infections. Assessment of immune function, neutrophil markers, acute phase reactants, and utilization of sepsis screening scores may contribute to the management of sepsis. Maternal decolonization, antimicrobial stewardship, early enteral feeding, and optimal infection control practices are potential practical strategies for reducing the burden of neonatal sepsis.

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“…Furthermore, several studies have indicated that quantitation of the neutrophil CD64 is a worthwhile candidate for evaluation as a more sensitive and specific indicator of sepsis than the other available diagnostics tests (7) , that has high diagnostic specificity and sensitivity of neonatal sepsis (8,9) .…”

Section: Introductionmentioning

confidence: 99%

Detection of the CD64 on Neutrophils and CD69 on Lymphocytes by Flowcytometry as a Marker for Early Diagnosis of Neonatal Sepsis

Khadhim¹

2017

jmscr

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Hematologic Profile of Sepsis in Neonates: Neutrophil CD64 as a Diagnostic Marker

Abstract: Neutrophil CD64 is a highly sensitive marker for neonatal sepsis. Prospective studies incorporating CD64 into a sepsis scoring system are warranted.

Cited by 153 publications

References 49 publications

Neutrophil, TLR2, and TLR4 expression in newborns at risk of sepsis

Neutrophil, TLR2, and TLR4 expression in newborns at risk of sepsis

Recent Developments and Current Issues in the Epidemiology, Diagnosis, and Management of Bacterial and Fungal Neonatal Sepsis

Detection of the CD64 on Neutrophils and CD69 on Lymphocytes by Flowcytometry as a Marker for Early Diagnosis of Neonatal Sepsis

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