Helicobacter spp. Infection Induces Changes in Epithelial Proliferation and E-cadherin Expression in the Gastric Mucosa of Pigs

Bracarense, Ana Paula Frederico Rodrigues Loureiro; Yamasaki, Letícia; Silva, E.O.; Oliveira, R. L.; Alfieri, Amauri Alcindo

doi:10.1016/j.jcpa.2013.06.002

Cited by 6 publications

(4 citation statements)

References 34 publications

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“…It can be seen that Helicobacter was uniquely elevated in the HFD group starting at Week 3 (Figure ) but no significant differences were observed in the other four groups. Generally, Helicobacter tend to colonize the stomach, intestines, liver, bile ducts, and heart. , Enterohepatic Helicobacter species including H. hepaticus , H. bilis , and H. cinaedi have been detected in the lower intestinal and biliary tract of animals, which may lead to chronic inflammatory bowel and liver diseases in rodents, poultry, and primates as well as gastroenteritis, cholecystitis, and liver diseases in human beings. ,, Thus, it can be speculated that the abnormal expansion of Helicobacter may be partially attributable to the retroaction of gene expression in liver for the HFD group.…”

Section: Resultsmentioning

confidence: 99%

Effects of Medium- and Long-Chain Triacylglycerols on Lipid Metabolism and Gut Microbiota Composition in C57BL/6J Mice

Zhou

Wang

Jacoby

et al. 2017

J. Agric. Food Chem.

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Obesity is related to an increasing risk of chronic diseases. Medium- and long-chain triacylglycerols (MLCT) have been recognized as a promising choice to reduce body weight. In this study, three MLCT with different contents of medium-chain fatty acids (MCFA) (10-30%, w/w) were prepared, and their effects on lipid metabolism and fecal gut microbiota composition of C57BL/6J mice were systematically investigated. MLCT with 30% (w/w) MCFA showed the best performance in decreasing body weight gain as well as optimizing serum lipid parameters and liver triacylglycerol content. The expression levels of genes encoding enzymes for fatty acid degradation increased markedly and expression levels of genes encoding enzymes for de novo fatty acid biosynthesis decreased significantly in the liver of mice treated with MLCT containing 30% (w/w) MCFA. Interestingly, the dietary intake of a high fat diet containing MLCT did significantly decrease the ratio of Firmicutes to Bacteroidetes and down-regulate the relative abundance of Proteobacteria that may attribute to weight loss. Furthermore, we found a notable increase in the total short-chain fatty acid (SCFA) content in feces of mice on a MLCT containing diet. All these results may be concomitantly responsible for the antiobesity effect of MLCT with relatively high contents of MCFA.

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Section: Resultsmentioning

confidence: 99%

Effects of Medium- and Long-Chain Triacylglycerols on Lipid Metabolism and Gut Microbiota Composition in C57BL/6J Mice

Zhou

Wang

Jacoby

et al. 2017

J. Agric. Food Chem.

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“…In contrast to man, the pathogenic role of Helicobacter sp. has not been substantiated in most domestic and wild animals and a definitive link to a disease is still lacking except for pigs, ferrets and cheetahs [19,[84][85][86][87][88]. Helicobacter acinonyx, closely related to Helicobacter pylori, is a specific organism described in cheetahs, lions and tigers.…”

Section: Inflammatory and Degenerative Lesionsmentioning

confidence: 99%

Pathology in Captive Wild Felids at German Zoological Gardens

et al. 2015

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This retrospective study provides an overview on spontaneous diseases occurring in 38 captive wild felids submitted for necropsy by German zoological gardens between 2004 and 2013. Species included 18 tigers, 8 leopards, 7 lions, 3 cheetahs and 2 cougars with an age ranging from 0.5 to 22 years. Renal lesions, predominantly tubular alterations (intra-tubular concrements, tubular degeneration, necrosis, intra-tubular cellular debris, proteinaceous casts, dilated tubuli) followed by interstitial (lympho-plasmacytic inflammation, fibrosis, metastatic-suppurative inflammation, eosinophilic inflammation) and glomerular lesions (glomerulonephritis, glomerulosclerosis, amyloidosis) were detected in 33 out of 38 animals (87%). Tumors were found in 19 of 38 felids (50%) with 12 animals showing more than one neoplasm. The tumor prevalence increased with age. Neoplasms originated from endocrine (11), genital (8), lympho-hematopoietic (5) and alimentary organs (4) as well as the mesothelium (3). Most common neoplasms comprised uterine/ovarian leiomyomas (5/2), thyroid adenomas/adenocarcinoma (5/1), pleural mesotheliomas (3), hemangiosarcomas (2) and glossal papillomas (2). Inflammatory changes were frequently encountered in the intestine and the lung. Two young animals displayed metastatic mineralization suggestive of a vitamin D- or calcium intoxication. One tiger exhibited degenerative white matter changes consistent with an entity termed large felid leukoencephalomyelopathy. Various hyperplastic, degenerative and inflammatory changes with minor clinical significance were found in several organs. Summarized, renal lesions followed by neoplastic changes as well as inflammatory changes in lung and gastrointestinal tract represent the most frequent findings in captive wild felids living in German zoological gardens.

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“…Some authors stated that by understanding this relationship, it should be possible to predict, treat, and even prevent the disease (AEBISCHER et al, 2010). The inflammatory response induced by the bacteria is a key-event related to the pathogenesis (BASSO et al, 2010), as the degeneration of the surface epithelium caused by infection triggers the inflammatory response to an infiltrate, which is composed of leukocytes (neutrophils, lymphocytes, and plasma cells) (SIQUEIRA et al, 2007;BRACARENSE et al, 2013). De WITTE et al (2017) observed that Helicobacter suis in adult pigs positively affects markers for acid secretion and inflammation, unlike the younger ones.…”

Section: Resultsmentioning

confidence: 99%

Helicobacter spp. and gastric lesions association in minipigs

et al. 2021

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Due to their similarity to humans, studies regarding gastric ulcers in pigs have become of great interest. It is known that Helicobacter spp. is related to the occurrence of these ulcers, as they possess a high prevalence in pigs. This study aimed to associate gastric lesions findings naturally occurring in minipigs related to or not related to the presence of Helicobacter spp., through the ultra-rapid urease test and immunohistochemical analysis, reaffirming the disease in swine as a natural biomedical model for human cases. For this, samples of formalin-fixed paraffin-embedded gastric tissues from 40 minipigs were obtained at the Laboratório de Morfologia e Patologia Animal (LMPA) in the Universidade Estadual do Norte Fluminense (UENF). Regarding the ultra-rapid urease test, no animal was positive in all regions. However, 18 were positive in at least one: six (15%) were positive in the aglandular region, eight (20%) in the antrum region, 13 (32.5%) in the region of the cardiac gland, and one (2.5%) in the region of the fundic gland. Regarding immunohistochemical analysis, only one animal was positive in all regions, and 32 animals were positive in at least one: four (10%) were positive in the aglandular region, 10 (25%) in the antrum region, 23 (57.5%) in the region of the cardiac gland, and three (7.5%) in the region of the fundic gland. The gastric lesion findings showed a close relationship with Helicobacter spp., enriching the laboratory animal pathologies list. The immunostaining of the bacteria not associated with gastric lesions in certain regions demonstrated the saprophytic and opportunisitic nature of Helicobacter.

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Helicobacter spp. Infection Induces Changes in Epithelial Proliferation and E-cadherin Expression in the Gastric Mucosa of Pigs

Cited by 6 publications

References 34 publications

Effects of Medium- and Long-Chain Triacylglycerols on Lipid Metabolism and Gut Microbiota Composition in C57BL/6J Mice

Effects of Medium- and Long-Chain Triacylglycerols on Lipid Metabolism and Gut Microbiota Composition in C57BL/6J Mice

Pathology in Captive Wild Felids at German Zoological Gardens

Helicobacter spp. and gastric lesions association in minipigs

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