Helicobacter pylori infection and peptic ulcers

The Impact of Digestive and Colon Drugs on the Human Hormones Profile

“…As many as 70-90 % of such ulcers are associated with Helicobacter pylori, a spiral-shaped bacterium that lives in the acidic environment of the stomach and nonsteroidal anti-inflammatory drugs (NSAIDs), including aspirin. Other important causes of gastric ulceration are gastric adenocarcinoma and lymphoma, and these must be excluded by biopsy and follow-up [1]. Moreover, one of the most common peptic ulcer complications is gastrointestinal bleeding [2,3].…”

Prevention of Gastric Ulcers

“…Despite that the prevalence of Helicobacter pylori is decreasing in developed countries, as a result of improvements in living standards and hygiene, Helicobacter pylori is still a common cause of gastric ulcer in developing countries. Attempts to develop effective vaccination against this bacterium reached phase I and II clinical trials, and may present effective preventive strategy in preventing gastric ulcer formation and, more importantly, preventing gastric cancer in the future (Majumdar et al, 2011).…”

Conventional and Novel Pharmaceutical Dosage Forms on Prevention of Gastric Ulcers

“…pylori is a gram-negative microaerophilic non-invasive spiral bacillus which has the ability to colonize the gastric mucosa (130). It causes indolent but chronic inflammation in the gastric mucosa and its clinical course is highly variable (131).…”

“…Its prevalence varies from more than 80% in developing countries to less than 20% in some developed countries, where it is steadily falling due to improved hygiene and sanitation, and possibly increased antibiotic use. Only about 15% of individuals infected with H. pylori develop a peptic ulcer: who develops disease depends on bacterial, host and environmental factors (130). The infection is usually limited to the antrum, resulting in hypersecretion of acid and the development of duodenal ulcers, which is basically an acid injury.…”