Prevention of Gastric Ulcers

Morsy, Mohamed A.; El-Sheikh, Azza A. K.

doi:10.5772/17942

Cited by 6 publications

(10 citation statements)

References 45 publications

(52 reference statements)

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“…The gastric damage (erosion or ulcer) area was determined with "Image J" image processing software (NIH, USA). The lesion index and lesion inhibition rate for each rat was calculated with the following formula (Equations (1) and (2)): lesion index (%) = (gastric damage area of each rat/gastric mucosal area of each rat) × 100 (1) lesion inhibition rate (%) = (1−total gastric damage area of sample treated group (PC and FL groups)/total gastric damage area of the gastric damage control (HE group) × 100.…”

Section: Preparation Of the Stomach Tissue Sample And Determination Omentioning

confidence: 99%

“…Gastric ulcers are the most common multifactorial gastrointestinal disorder and are accompanied by symptoms such as bloating, gas, fever, abdominal pain, nausea, and vomiting. Major causes include infection with the bacterium Helicobacter pylori, (H. pylori), long-term use of aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs), smoking, and alcohol consumption [1]. These risk factors can erode the stomach's defense system against the overproduction of acid, and the damage to the stomach wall can result in an ulcer.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, excessive alcohol intake can directly affect the gastric mucosal tissues and increase the permeability by an increase in acid back diffusion. This disruption of the mucosal defensive and aggressive factors may result in gastric cancer [1].…”

Section: Introductionmentioning

confidence: 99%

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Gastroprotective Effects of Fermented Lotus Root against Ethanol/HCl-Induced Gastric Mucosal Acute Toxicity in Rats

et al. 2020

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Gastric ulcers are a common gastrointestinal disease across the globe. Alcohol consumption is the primary cause of gastric carcinogenesis and progression. We investigated the gastroprotective effects of fermented lotus root (FL) against ethanol (EtOH)/HCl-induced gastric ulcers in a rat model and the conceivable underlying mechanisms involved. Rats received different doses of FL (50, 100, and 200 mg/kg) or ranitidine (positive control, 30 mg/kg) via oral gavage daily for 14 days. One hour after the last oral administration of FL, the EtOH/HCl mixture was orally intubated to induce gastric damage. Oral administration of FL significantly alleviated the gastric lesions. Moreover, FL also elevated the amounts of nitric oxide and the antioxidant enzyme activities of superoxide dismutase, glutathione peroxidase, and catalase in the stomach. To verify the gastric mucosal defense mechanism, inflammation-related genes were measured. Our results revealed that FL effectively inhibited gastric mucosal damage via downregulation of the nuclear factor-kappaB (NF-κB) response in the stomach. The administration of FL significantly lowered the gastric mRNA expression of inflammation-related genes, including NF-κb1, tumor necrosis factor-α, interferon γ, and prostaglandin-endoperoxide synthase 2, compared with the gastric ulcer control group. In addition, the NF-κB signaling pathway-related protein markers inhibitor of κB (IκB)-α, IκB kinase, and NF-κB were significantly reduced in the FL groups. Taken together, these data suggest that FL administration may have potential as an alternative treatment for gastric ulcers due to its antioxidant and anti-inflammatory effects and its ability to promote the recovery of gastric mucosa.

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Section: Preparation Of the Stomach Tissue Sample And Determination Omentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Gastroprotective Effects of Fermented Lotus Root against Ethanol/HCl-Induced Gastric Mucosal Acute Toxicity in Rats

et al. 2020

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“…Nitric oxide is another important factor which modulates mucosal blood flow and epithelial permability. [567] Stable endothelial barrier provider perlecan is an important component of vascular structures. It interacts with many extracellular matrix components, laminin, collagen Type IV, FGF7…, etc.…”

Section: Discussionmentioning

confidence: 99%

“…[13] The stable endothelial barrier is provided by perlecan which is an important component of vascular structures. [56] Recurrent gastroduodenal bleeding is not a previously reported feature. Thus perlecan deficiency in Schwartz–Jampel syndrome patients may cause recurrent gastroduodenal bleeding.…”

Section: Introductionmentioning

confidence: 98%

Schwartz–Jampel syndrome with gastroduodenal bleeding

et al. 2016

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Schwartz–Jampel syndrome is a rare autosomal recessive disorder with joint contractures, generalized myotonia, skeletal anomalies, and facial dysmorphism. The patients with Schwartz–Jampel syndrome have muscle stiffness and electromyography reveals complex, repetitive discharges as myotonic discharges. It is unusual for a Schwartz-Jampel syndrome case to have recurrent gastrointestinal bleeding episodes. The stable endothelial barrier is provided by perlecan which is an important component of vascular structures. Thus, perlecan deficiency may cause recurrent gastroduodenal bleeding. Our report is unique with being the first reported Schwartz–Jampel syndrome case with gastrointestinal bleeding.

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Oleic acid as a restorative agent in alleviating adrenaline induced altered morphofunctional milieu of gastric tissue and mitochondria

Mishra

Chattopadhyay

Naaz

et al. 2021

Heliyon

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The role of oleic acid as a protective antioxidant has recently been recognized. The present study is aimed to explore whether oleic acid can afford protection to rat gastric tissue when challenged with adrenaline. Sixty adult healthy male albino rats were divided into 10 groups comprising of 6 animals each. First group constituted the control. Rats of the second group were injected sub-cutaneously with adrenaline bitartrate at the dose of 0.3mg/kg body weight, every day for a period of 17 days. Rats of the third, to the sixth groups were orally fed with different doses of oleic acid (2.5, 5, 10, 20 mg/kg body weight/day) respectively. The rats of seventh to tenth groups were orally fed with doses of oleic acid as mentioned above and subsequently injected with adrenaline bitartrate at 0.3mg/kg body weight sub-cutaneously. After the treatment period, the animals were euthanized through cervical dislocation following light ether anaesthesia and gastric tissues were collected for morphological and biochemical studies. Subcutaneously administered pharmacological dose of adrenaline bitartrate caused oxidative stress inducing gastric lesion in male albino rats as evident from the altered levels of biomarkers of oxidative stress, activities of antioxidant and mitochondrial enzymes related to energy metabolism with changes in tissue morphology. Pre-treatment of rats with oleic acid dose-dependently protected against these gastric injuries induced by adrenaline indicating the potentiality of oleic acid in protecting against adrenaline induced gastric injury in male albino rats where antioxidant mechanisms appear to play a pivotal role in mediating such protection.

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Prevention of Gastric Ulcers

Cited by 6 publications

References 45 publications

Gastroprotective Effects of Fermented Lotus Root against Ethanol/HCl-Induced Gastric Mucosal Acute Toxicity in Rats

Gastroprotective Effects of Fermented Lotus Root against Ethanol/HCl-Induced Gastric Mucosal Acute Toxicity in Rats

Schwartz–Jampel syndrome with gastroduodenal bleeding

Oleic acid as a restorative agent in alleviating adrenaline induced altered morphofunctional milieu of gastric tissue and mitochondria

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