Conventional and Novel Pharmaceutical Dosage Forms on Prevention of Gastric Ulcers

Tailored Hydrogel Microbeads of Sodium Carboxymethylcellulose as a Carrier to Deliver Mefenamic Acid: Transmucosal Administration

“…The water soluble hydrophilic polymers such as Na CMC hydrate rapidly and create pores. These pores are filled with the solvent, which distributes within the microbeads and thus accelerates the erosion of the gel layer (33).…”

“…However, in the case of F 1 microbeads, the drug release was lesser (85.52%) than that of the F 3 microbeads (103.74%). Na CMC as a polymer indicates poor release prolonged result owing to the presence of wide amount of hydroxyl groups, which guides to extremely swollen matrix and causes loose gel layer formation, pursued by erosion, if reportedly due to the weakening of the CMC hydrogel matrix (33). During dissolution, the formulations prepared using Na CMC as a polymer were swelled making a gel layer on the represented surface of microbeads.…”

Novel delivery systems with nonsteroidal anti-inflammatory drugs

“…Međutim, kod preparata NSAIL koji ispoljavaju sistemsko delovanje, incidenca neželjenih dejstava je visoka, čak i u slučajevima primene pomenutih inovativnih formulacija. Takođe, neke lekovite supstance primenjene oralnim putem podležu metabolizmu prvog prolaza, čime se smanjuje efektivna koncentracija leka u plazmi (4,6,7,52).…”

Potential Oral Protective Effects of SNEDDS of Diclofenac Sodium on Experimental Gastric Ulcers in Rats

“…When administered orally, side effects such as gastric-duodenal ulcers and its short half-life are problems in clinical. Various strategies have been explored to avoid NSAIDs related toxicity, including concomitant administration of gastric protectors [4] use of rectal drug delivery systems [5], or modified release formulations [6]. The development of oral controlled and sustained release offers a potential benefit for NSAIDs.…”