Helicobacter pylori in colorectal neoplasms: is there an aetiological relationship?

Abstract

Background: This pilot study was carried out to determine whether Helicobacter pylori can be detected in normal colon or in association with colorectal neoplasia.

The Role of Infectious Agents in Colorectal Carcinogenesis

“…The prevalence of H. pylori was higher in villous type polyps than in tubular type polyps and adenocarcinomas. Contrary to this finding, Jones et al (2007) demonstrated that villous adenoma had the lowest rate of H. pylori positivity compared to other premalignant and malignant colonic lesions. Their results also showed significant associations of H. pylori positivity with tubular and tubulovillous adenomas, and adenocarcinomas, but not with villous adenomas.…”

Seroprevalence of Helicobacter pylori in patients with colon adenomas in a brazilian university hospital

“…Some studies were able to identify the genetic material of the bacteria in colonic neoplasias (3,8,15) . The effect of the intestinal flora as a carcinogenic agent has been evaluated and the possibility exists that bacteria such as H. pylori circulating in the intestines could directly activate carcinogenesis (33) .…”

Helicobacter pylori Infection and the Risk of Colorectal Adenoma and Adenocarcinoma: an Updated Meta-analysis of Different Testing Methods

“…Like serologic studies, studies using PCR methods have been equivocal. Two studies found that detection of H. pylori via PCR was significantly higher in colorectal adenocarcinoma tissues compared with normal colorectal tissues (Grahn et al, 2005;Jones et al, 2007), but a third study found that only 1.2% of malignant colorectal tissue samples were positive for H. pylori, compared with 6% of normal tissues (Bulajic et al, 2007). The 13C-urea breath test has 97% sensitivity and specificity in H. pylori detection (Chen et al, 2003); however, as in PCR-based studies, the evidence is not convincing.…”