Helicobacter pylori Infection and the Risk of Colorectal Adenoma and Adenocarcinoma: an Updated Meta-analysis of Different Testing Methods

Chen, Yaosheng; Xu, Songxin; Ding, Yanbing; Huang, Xin-En; Deng, Bin

doi:10.7314/apjcp.2013.14.12.7613

Cited by 31 publications

(26 citation statements)

References 53 publications

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“…Chen et al. , in a meta‐analysis demonstrated that H. pylori infection indeed increases the risk of colorectal adenoma and adenocarcinoma (OR: 1.49; 95% CI: 1.30–1.72). Hsu et al.…”

Section: Colonic and Pancreatic Diseasesmentioning

confidence: 99%

Helicobacter pylori and Extragastric Diseases

Franceschi¹,

Tortora

Gasbarrini³

et al. 2014

Helicobacter

127

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While Helicobacter pylori infection was initially revealed to be associated only with some gastroduodenal diseases, further studies have shown its possible role in several extragastric diseases. For idiopathic thrombocytopenic purpura, sideropenic anemia, and vitamin B12 deficiency, the diagnosis of H. pylori infection is recommended, and there are many other conditions such as cardiovascular, neurological, dermatological, and respiratory diseases in which H. pylori may possibly play a role. Interestingly, a potential role has also been described for GI neoplastic diseases, including colorectal and pancreatic cancer. Different mechanisms of action have been proposed, ranging from the induction of a low grade inflammatory state to the occurrence of molecular mimicry mechanisms. This review summarizes the results of the most relevant studies published on this topic over the last year.

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“…Chen et al. , in a meta‐analysis demonstrated that H. pylori infection indeed increases the risk of colorectal adenoma and adenocarcinoma (OR: 1.49; 95% CI: 1.30–1.72). Hsu et al.…”

Section: Colonic and Pancreatic Diseasesmentioning

confidence: 99%

Helicobacter pylori and Extragastric Diseases

Franceschi¹,

Tortora

Gasbarrini³

et al. 2014

Helicobacter

127

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“…Helicobacter pylori is a human pathogen that colonizes the gastric mucosa in approximately 50% of the global population . Although the causal link is still debated, several meta‐analyses have suggested that H. pylori infection confers a 1.5‐ to 1.8‐fold and 1.3‐ to 1.6‐fold increased risk of colorectal adenoma (CRA) and colorectal cancer (CRC), respectively . Advanced CRA (ACA) is a clinically relevant precursor to CRC, and advanced colorectal neoplasia (ACN) is the primary target of CRC screening .…”

Section: Introductionmentioning

confidence: 99%

The association between Helicobacter pylori infection and the risk of advanced colorectal neoplasia may differ according to age and cigarette smoking

Park

et al. 2018

Helicobacter

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“…Several meta-analyses (Zumkeller et al, 2006; Zhao et al, 2008; Hong et al, 2012; Chen et al, 2013; Rokkas et al, 2013; Wu et al, 2013; Guo and Li, 2014; Liu and Zheng, 2016) have obtained combined odds ratios (OR) over the unity (range from 1.08 to 1.63), suggesting an increased CRC risk associated with H. pylori infection. However, heterogeneity among studies and insufficient control for confounding factors in most of them entail a high degree of uncertainty, which precludes from deriving solid conclusions.…”

Section: Introductionmentioning

confidence: 99%

Helicobacter pylori Antibody Reactivities and Colorectal Cancer Risk in a Case-control Study in Spain

et al. 2017

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Background: Several studies have suggested that Helicobacter pylori (H. pylori) infection is a risk factor for colorectal cancer (CRC), while others have not confirmed this hypothesis. This work aimed to assess the relation of CRC with H. pylori seropositivity and with seropositivity to 16 H. pylori proteins, in the MultiCase-Control study, MCC-Spain.Methods: MCC-Spain is a multicase-control study carried out in Spain from 2008 to 2013. In total, 2,140 histologically-confirmed incident CRC cases and 4,098 population-based controls were recruited. Controls were frequency-matched by sex, age, and province. Epidemiological data were collected through a questionnaire fulfilled by face-to-face interviews and a self-administered food-frequency questionnaire. Seroreactivities against 16 H. pylori proteins were determined in 1,488 cases and 2,495 controls using H. pylori multiplex serology. H. pylori seropositivity was defined as positivity to ≥4 proteins. Multivariable logistic regression mixed models were used to estimate odds ratios (OR) and 95% confidence intervals (CI).Results: H. pylori seropositivity was not associated with increased CRC risk (OR = 0.91; 95% CI: 0.71–1.16). Among H. pylori seropositive subjects, seropositivity to Cagδ showed a lower CRC risk, and risk decreased with increasing number of proteins seropositive. Seropositivity to the most recognized virulence factors, CagA and VacA, was not associated with a higher CRC risk. No statistically significant heterogeneity was identified among tumor sites, although inverse relations were stronger for left colon cancer. An interaction with age and sex was found: H. pylori seropositivity was associated with a lower CRC risk in men younger than 65 and with a higher risk in older women.Conclusions: Our results suggest that neither H. pylori seropositivity, nor seropositivity to the virulence factor CagA are associated with a higher CRC risk. A possible effect modification by age and sex was identified.

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Helicobacter pylori Infection and the Risk of Colorectal Adenoma and Adenocarcinoma: an Updated Meta-analysis of Different Testing Methods

Cited by 31 publications

References 53 publications

Helicobacter pylori and Extragastric Diseases

Helicobacter pylori and Extragastric Diseases

The association between Helicobacter pylori infection and the risk of advanced colorectal neoplasia may differ according to age and cigarette smoking

Helicobacter pylori Antibody Reactivities and Colorectal Cancer Risk in a Case-control Study in Spain

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